• Journal of Biomedical Engineering Research
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• v.16 no.2
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• pp.121-128
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• 1995

Information about retinal blood vessels can be used in grading disease severity or as part of the process of automated diagnosis of diseases with ocular menifestations. In this paper, we address the problem of detecting retinal blood vessels and optic disk (papilla) in eye-fundus images. We introduce an algorithm for feature extraction based on Fuzzy Clustering algorithm (fuzzy c-means). A method of finding the optic disk (papilla) is proposed in the eye-fundus images. Additionally, the inrormations such as position and area of the optic disk are extracted. The results are compared to those obtained from other methods. The automatic detection of retinal blood vessels and optic disk in the eye-rundus images could help physicians in diagnosing ocular diseases.

• Journal of Oriental Neuropsychiatry
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• v.23 no.2
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• pp.59-66
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• 2012

Objectives : The purpose of this report was to examine the relation between ocular fatigue and dry eye symptoms in patients with ocular fatigue. Methods : 115 patients with ocular fatigue disease were included in this analyses. The study examination included a symptom interview that assessed stiff sense, foreign body sense, pain, soreness, redness, etc. and ocular fatigue. Results : The survey showed in subjective ocular fatigue in all subjects. All patients(115) reported symptoms of ocular fatigue and 25.2% (29/115) were diagnosed as having dry eye with symptoms. Conclusions : These findings suggest that there is a strong between ocular fatigue and dry eye.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.2
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• pp.69-73
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• 2008

Purpose: The purpose of this study is to investigate the antibacterial activity Xanthium strumarium L. extract against bacteria causing eye disease and to examine the possibility as a natural preservative on behalf of synthetic preservatives which are added to the contact lens solution. Methods: Antibacterial activity of Xanthium strumarium L. extract against the bacteria causing eye disease was assessed using agar diffusion method, and determined by whether clear zone was formed around paper disc and in terms of the size(mm) of clear zone.Staphylococcus aureus and Pseudomonas aeruginosa were used in the study. Results: Xanthium strumarium L. extract provided activity against Staphylococcus aureus KCCM 40050 in a concentration of $1000{\mu}g/20{\mu}l$with an clear zone of 11.5 mm. Moreover, Xanthium strumarium L. extract showed an activity against Pseudomonas aeruginosa KCCM 11803 in a concentration of $1000{\mu}g/20{\mu}l$with an clear zone of 9.0 mm, and against Pseudomonas fluorescens KCCM 40223 with an clear zone of 7.0 mm. Conclusions: Antibacterial activity of Xanthium strumarium L. extract against the bacteria causing eye disease was proved. This result suggests that Xanthium strumarium L. extract can be a potential natural preservative, which is added to contact lens solution.

• Journal of Oriental Neuropsychiatry
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• v.23 no.3
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• pp.117-128
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Joganiknoe-tang on diplopia and ptosis from cerebrovascular disease. Methods : We recruited 2 patients who have diplopia and ptosis because of cerebrovascular disease. In addition, the patients had been administrated by Joganiknoe-tang. Diplopia and ptosis of patients had been estimated with VAS (Visual Analogue Scale) and difference of both eye's interpalpebral fissure. We measured VAS (Visual Analogue Scale) and difference of both eye's interpalpebral fissure for every five days Results : After the treatments, symptoms were decreased and almost disappeared. In both cases, diplopia patients complained decreased from VAS 10 to VAS 1, and difference of both eye's interpalpebral fissure disappeared Conclusions : This study suggests that Joganiknoe-tang is significantly effective on diplopia and ptosis because of cerebrovascular disease.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.4
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• pp.19-29
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• 2023

Objectives : The purpose of this study is to retrospectively analyze 3 years of inpatient ophthalmology consultation to Korean medicine ophthalmology, otolaryngology & dermatology department in Korean medicine hospital. Methods : We classified ophthalmological inpatient consultations between September 1st, 2019 and August 31st, 2022, based on electronic medical record by gender, age, hospitalized department, categories of diseases. Results : Total number of consultations were 111, and the average of age was 63.6. The proportion of female and male were 2.5:1. Among the 136 cases of eye disease referred, lacriminal production and discharge diseases accounted for the most at 54 cases(39.7%), of which 44 cases were dry eyes syndrome. Excluding dry eye syndrome, conjunctival disease occurred the most with 24 cases(17.6%). Consultations from department of Korean rehabilitation medicine, and Korean internal medicine were most common, because they have a comparatively large number of inpatients and long hospitalization period. Conclusions : This study identified the frequency of consultation and the disease group with many requests for each department. When inpatients complain of eye disease, consultation to Korean medicine ophthalmology, otolaryngology & dermatology department should be encouraged as accurate diagnosis and treatment using specialized equipment is possible and can be used for the purpose of progress observation and examination.

• The Korean Journal of Nuclear Medicine
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• v.22 no.1
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• pp.27-31
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• 1988

In Graves' disease, changes in orbital tissue and structure are casued by inflammatory infiltation, which induces increase of capillary permeability and breakdown of blood-tissue barriers. Using the uptake of $^{99m}Tc-DTPA$ in inflammatory lesion, Eye/Brain radioactivity ratios in brain scintigraphy were evaluated in 15 normal controls and 40 Graves' patients. The results were as follows; 1) Eye/Brain radioactivity ratio was significantly higher in Graves' ophthalmopthy group than in control group (p < 0.005). 2) In Graves' ophthalmopathy, Eye/Brain radioactivity ratio was significantly higher in active (progressive) group than in inactive (non-progressive) group (p < 0.05). 3) There was no correlation between class of ATA classification of Graves' ophthalmopathy and Eye/Brain radioactivity ratio. 4) There was no correlation between Eye/Brain radioactivity ratio and serum activity of TBII. In conclusion, Eye/Brain radioactivity ratio using $^{99m}Tc-DTPA$ brain scintigraphy may be useful to determine the activity of Graves' ophthalmopathy and whether treatment of Graves' ophthalmopathy is necessary or not.

• BMB Reports
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• v.46 no.2
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• pp.124-129
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• 2013

FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. PEP-1-FK506BP efficiently transduced into human corneal epithelial cells in a time- and dose-dependent manner, and remained stable in the cells for 48 h. In addition, we demonstrated that topical application of PEP-1-FK506BP was transduced into mouse cornea and conjunctiva by immunohistochemistry. Furthermore, topical application of PEP-1-FK506BP to BTX-A-induced mouse model markedly inhibited expression levels of pro-inflammatory cytokines such as interleukin-$1{\beta}$ (IL-$1{\beta}$), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and macrophage inhibitory factor (MIF) in corneal and conjunctival epithelium. These results suggest PEP-1-FK506BP as a potential therapeutic agent for dry eye diseases.

• Journal of Chest Surgery
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• v.27 no.5
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• pp.402-406
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• 1994

Behcet`s disease is a rare systemic disease of unknown cause and it is a progressive disorder with episodes of activity and remission. The major features are oral and genital ulceration and skin and eye lesions. Pulmonary involvement is rare, and we have experienced a 38 year old female patient who had undergone right lower lobe lobectomy due to extensive, rapidly growing pulmonary thromboemboli and pseudoaneurysm in pulmonary artery.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1103-1107
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• 2018

Purpose: To evaluate the clinical effect of intense regulated pulse light (IRPL) and changes in tear film thickness in dry eye patients. Methods: A retrospective study was conducted on 25 patients with Meibomian gland dysfunction who had subjective dry eye discomfort and whose tear film break-up time (TBUT) was < 10 seconds. All patients were treated with IRPL three times on days 1, 15, and 45. TBUT, Schirmer 1 test results, cornea staining score with fluorescein, ocular surface disease index (OSDI), and lipid layer thickness were measured and compared before and after the procedure. Results: TBUT was significantly increased from $3.7{\pm}1.2s$ to $4.4{\pm}2.1s$ after IRPL (p = 0.03). Schirmer 1 test and cornea staining scores changed significantly (p < 0.01 and p = 0.01, respectively). OSDI also showed a statistically significant improvement from $39.5{\pm}17.5points$ to $30.4{\pm}18.7points$ (p = 0.01). However, no significant difference in lipid layer thickness was observed (p = 0.49). Conclusions: IRPL is an effective treatment modality to improve TBUT, Schirmer 1 test scores, cornea staining scores, and subjective dry eye symptoms.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.4
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• pp.121-126
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• 2008

Purpose: To study the minimum diopter of spherical lens with normal binocular function in induced anisometropia by over-correction or under-correction in single eye. Methods: Stereoacuity of subjects without ophthalmic disease history in their twenties was measured by using Titmus-fly stereotest at 40 cm after overcorrection or under-correction in non-dominant eye or dominant eye, respectively. Results: In induced anisometropia, the stereoacuity decreased with increase of the power of added spherical lens in either nondominant eye or dominant eye. And the first reduction of stereoacuity was more prominent with the addition of (+) spherical lens than (-) spherical lens. In addition, there was more strikingly decrement of stereoacuity with addition of spherical lens to dominant eye than non-dominant eye. Conclusions: In induced anisometropia, the most outstanding reduction of stereoacuity was obtained with increment of the power of added (+) spherical lens in case of non-dominant eye with full correction and dominant eye with addition of spherical lens.