• Korean Journal of Community Nutrition
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• v.1 no.1
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• pp.47-60
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• 1996

This study was carried out to investigate growth performance, energy and protein metabolism of breast and formula fed infants from birth to 3 months postpartum. There were four groups : breast fed(BF) and three formula fed groups(FFM, FFN and FFP). There was no significant difference in the height of infants according to feeding method and formula brands. However, mean weight of FFM was significantly higher than that of FFP and BF at 1 and 3 months postpartum, respectively. Mean head circumference of FFN was lowest among groups. The average intake of breast milk was $781.4{\;}{pm}{\;}119.3m{\ell}/day$ and that of formula was $848.6{\;}{pm}{\;}118.5m{\ell}/day$. Mean apparent digestible energy intakes of formula-fed infants and breast-fed infants during 3months were 568.9 $\pm$146.9 kca1/day and 657.9$\pm$212.8 kca1/day, respectively. The average protein intake of brest-fed and formula-fed infants were 8.3$\pm$1.6g/day and 14.1$\pm$14.1 g/day, respectively. The protein intakes of formula-fed infants were significantly higher than those of breast-fed infants at 1, 2, 3 months. The apparent protein digestibility of breast-fed infants was singnificantly higher compared to formula fed infant. These data suggest that RDA for infants be established and breast feeding be encouraged.

• Korean Journal of Community Nutrition
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• v.5 no.2
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• pp.273-279
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• 2000

This study was carried out to evaluate the calcium and phosphorus intakes and correlation with growth performance of 25male breast and formula-fed infants from 1 to 3 months postpartum. There were four groups breast-fed(BF) and three formula-fed groups(FFM, FFN and FFP). There was no significant difference in the height and weight of infants according to feeding methods and formula brands. Milk intake and the concentration of calcium and phosphorus from human milk and the formulas were measured. The average calcium content of human milk was 26.6$\pm$4.1mg/dl and 13.5$\pm$2.0mg/dl, respectively. The average calcium intakes of the brest-fed and formula-fed infants were 205.5$\pm$29.3mg/day and the 460.5$\pm$70.6mg/day, respectively the average calcium intake of breast-fed infants was significantly lower than that of formula fed infant. The percent of RDA(41%) of breast-fed infants was lower than that(75.4%) of formula fed infant. The average phosphorus intake of the brest-fed and formula-fed infants were 105.1$\pm$20.1mg/day and 288.3$\pm$37.3mg/day, respectively. The precent of RDA(27%) for brest fed was significantly lower than that(75.4%) of formula fed. The Ca/P ratios were 2.1 in brest fed and 1.6 in formula fed infant. The average calcium and phosphorus intakes of the formula fed infants was higher than that of the brest-fed infants. This data suggests the calcium and phosphorus intakes form human milk sufficiently support the growth of infants. Therefore, the level of calcium and phosphorus recommended dietary allowances for infants should be reduced.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.4
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• pp.397-404
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• 2005

The propose of this study was to investigate taurine intake in formula-fed and breast-fed infants and to estimate the level of taurine of blood and urine in order to determine the requirement of taurine intake in infants. These results will be useful to suggest the guideline of requirement of taurine intake and may contribute toward the proper use of breast milk substitutes. Experimental groups were breast-fed infants (n=10) and formula-fed infants (n=10) of 20 normal delivery infants in general hospital. This study was longitudinal study from birth up to 16weeks (0 week, 4 weeks, 8 weeks, 12 weeks, 16 weeks). The items of test were anthropometry(weight, height, head circumference, chest circumference), intake of taurine, taurine level of blood and urine in breast-fed and formula-fed infants. There were no significant differences between breast-fed and formula-fed infants in weight, height, head and chest circumference. There is a need for future studies of exclusive infants with larger samples to determine which growth pattern should be considered as the norm. Taurine concentration of plasma and urine did not differ between breast-fed and formula-fed infants. Taurine intake recommendations for infants is about 30mg/day from this study. This data will be useful for production of human-like formula milk and suggestion of an index of selection of a consumer in taurine.

• Korean Journal of Community Nutrition
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• v.2 no.2
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• pp.133-140
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• 1997

The serum concentrations of the major minerals(calcium, phosphorus, magnesium, sodium, potassium) and trace elements(iron, Zinc, copper manganese)were datermined in 23 breast fed infants living in Eumsung, Choong-buk region. The results obtained are summarized as follows: 1)The mean levels of calcium, phosphorus, magnesium, sodium and potassium of the serum of total subjects were 8.15$\pm$0.33mg/dI, 11.06$\pm$0.16mg/dI, 2.00$\pm$0.14mg/dI, 3.4476$\pm$17.99mg/dI and 9.06$\pm$2.04mg/dI respectively. 2)The serum concentrations of iron, zinc, copper and manganese in total subjects averaged 95.83$\pm$0.33mg/dI, 93.79$\pm$7.06$\mu$g/dI and 98.57$\pm$7.06 $\mu$g/dI and 4.93$\pm$0.62$\mu$g/dI respecitively. 3)Breast fed infants had significantly higher serum calcim, magnesium, sodium and iron concentrations than the formula fed groups. Otherwise, serum potassium, copper and manganese levels in breast milk fed infants were significantly lower than those in formula fed infants. 4) In formula fed infants, serum potassium and copper levels increased increased significantly with months after birth.

• Journal of the East Asian Society of Dietary Life
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• v.7 no.1
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• pp.87-95
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• 1997

One- to three-month-old infants (n=232) were compared their upper arm cumference and skinfold thickness(triceps, subscapular) by feeding methods in cross-sectional study. There were two groups : breast-fed(BF) and formula-fed groups(FF). As reported previously, weight, length, head and chest circumferences of these infants were good, and overall growth status was not significantly different by feeding methods, but weight, weight velocity and chest circumference of formula-fed infants were higher than breast-feds at 3month, significantly. Hear, the triceps skinfold thickness of infants at 1, 2, and 3 postpartum months were 7.4, 9.5 and 10.5 mm, respectively. The triceps skinfold thickness of breast-fed infants were higher than formula-feds at 1 and 2 postpartum month, but at 3 month that of formula-fed infants was greater than breast-fed infants, insignificantly. The subscapular skinfold thickness of infants were 6.4, 9.2 and 10.6 mm at 1 to 3 postpartum months, respectively. The upper arm circumference of infants were 11.7, 13.4, 14.3cm, and the arm muscle diameter were 34.5,39.3 and 41.7cm at one to three postpartum months, respectively. The upper arm circumference of male infants was higher than females at 2, 3 postpartum months. Overall, there were no signifiant differences between feeding methods in triceps and subscapular skinfold thickness, upper arm circumference and arm muscle diameter. But 3-month-old formula-fed male infant showed bigger significantly in arm circumference than the breast-feds. From this survey, long-term survey on growth and body composition of large scales might be necessary to determine the effect of feeding methods of infants after 3 months and to set proper body composition standard for infant.

• Korean Journal of Community Nutrition
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• v.2 no.1
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• pp.3-12
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• 1997

One-to three -month-old infants(n=252) were compared their growth performance(weight, length, head circumference, chest circumference) by feeding methods in cross-sectional study. There were two groups : breast-fed(BF) and formula-fed groups(FF). The weights of infants at 1, 2, and 3 postpartum month were 4.50$\pm$0.48kg, 5.76$\pm$0.62kg and 6.67$\pm$0.68kg, respectively. The weigh of male infants was higher than females. The length were 53.7$\pm$2.6cm, 57.4$\pm$3.3cm, 61.1$\pm$3.1cm at one to three postpartum months, respectively. The length of male infants was higher than females, too. Overall there were no significant differences between feeding methods in weight, length, head and chest circumferences, and monthly weight and length velocity. But 3-month-old formula-fed male infants showed bigger significantly in weight, monthly weight velocity and chest circumference than the breast-feds. By Korean standards, weight-for-height Z-score were distributed from 0 to ＋2. Not only was there a few malnourished infants but also overnourished were noticed, especially in formula-fed group. From this survey, long-time survey on growth and development of large scales might be necessary to determine the effect of feeding methods of infants after 3 months and to set proper grwoth standard for infant. And it was suggested the that the careful attention of polarized nutritional problems of early infants was needed, especially in formula-fed group. (Korean J Community Nutrition 2(1) : 3~12, 1997)

• Journal of Nutrition and Health
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• v.36 no.8
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• pp.841-850
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• 2003

Soy-based formula has been used for centuries in Korea. Soybeans contain phytochemicals with a biochemically active component, isoflavone. Isoflavone is a kind of phytoestrogens, structurally and functionally similar to estrogen. This study was conducted to investigate the effects of soy-based infant formula on growth, development, and isoflavone concentration in the plasma and urine. Thirty-nine healthy infants who were delivered at K university medical center were recruited. Experimental groups were the breast milk group (n = 15, BM) who were fed breast milk, soy-based formula group (n = 10, SBF) who were fed soy-based infant formula, and the casein-based formula group (n = 14, CBF) who were fed casein-based infant formula for 4 months. HPLC analysis was used to measure the concentration of isoflavones. The measurements of infant weight, length, head circumference and chest circumference were all in the normal growth range and were similar among the experimental groups. No significant differences were found in the scores of total mean of infant development test (Development Quotient, DQ) among the experimental groups. The isoflavone content of soy-based formula was significantly higher than. that of breast milk and casein-based formula. Plasma concentration of daidzein and genistein in the infants fed soy-based formula (daidzein : 264.1 ng/ml, genistein : 392.1 ng/ml) was significantly higher (p<.0001) than that in infants fed breast milk (daidzein : 3.4 ng/ml, genistein : 3.8 ng/ml) and casein-based formula (daidzein: 8.1 ng/ml, genistein: 9.3 ng/ml). Also, urinary daidzein and genistein concentrations in infants fed soy-based formula (daidzein: 19.82 $\mu$g/ml, genistein : 17.89 $\mu$g/ml) were significantly higher (p<.001) than those in infants fed breast milk (daidzein: 0.28 $\mu$g/ml, genistein : 0.22 $\mu$g/ml) and casein-based formula (daidzein : 0.45 $\mu$g/ml, genistein : 0.33 $\mu$g/ml).

• Korean Journal of Community Nutrition
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• v.4 no.1
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• pp.30-36
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• 1999

This study was carried out to longitudinally investigate the iron and zinc intakes and correlation with growth performance of 25 male breast-and formula-fed infants from 1 to 3 months postpartum, longitudinally. There were four groups breast fed(BF) and three formula fed groups((FFM, FFN and FFP). Milk intakes and the concentration of iron and zinc from human milk and the formulas were measured. The iron content of human milk was $2.07\pm{1.05(0.63~5.65)}\mu{g}$/ml. The zinc content was $2.43\pm{1.14(0.70~5.30)}\mu{/ml.}$ Both were not significantly different among postpartum months. The average iron intake of the breast-fed and formula-fed infants was $1.6\pm{0.7mg/}$day and $8.4\pm{2.3mg}$/day, respectively. The iron intake of breast-fed infants was higher than previous reports. And that of formula-fed infants was higher than the RDA. The average zinc intake of the breast-fed group was $1.9\pm{0.9mg/}$day and formula-fed infants' was $2.7\pm{0.7mg/}$day, which was higher than the RDA. There was no correlation between these mineral intakes and the growth performance during 1 to 3 postpartum months. So, extensive studies of the iron content of human milk and wide cross-sectional studies for establishing iron and zinc recommended dietary allowances for infants are needed.

• Journal of Nutrition and Health
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• v.26 no.6
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• pp.783-792
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• 1993

This study examined the difference in growth rate between Korean breast-fed(BF) and formula-fed(FF) infants(n=31) at 1, 2 and 3 months postpartum. The results indicated that the growth rate was comparable between groups, but that of the BF infants tended to be slow during the first three months. The intakes of energy, protein and lipid except lactose of the FF infants were greater than those of the BF infants, however the difference in growth rate did not correlate to these variables. But these results suggest that the availability of nutrients might be different between the BF infants and the FF infants.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.3
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• pp.270-281
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• 2019

Purpose: To compare the effectiveness of the magnesium (Mg)-enriched formula vs. control formula in constipated infants. Methods: An open-label, interventional, and the comparator-controlled study was conducted to evaluate the effectiveness of the Mg-enriched formula in formula-fed infants ${\leq}6$ months old presenting with functional constipation according to modified Rome IV criteria. Infants were randomized 1:1 to intervention or control formula for 30 days. Parents recorded stool consistency (hard, normal, or watery) and frequency on days 1-7 and 23-29. Physicians recorded patient baseline characteristics and performed the clinical examination at the time of three patient visits (baseline, day 8, and 30). Results: Of the 286 recruited infants, 143 received the Mg-rich formula and 142 received the control formula. After 7 days, significantly more infants had stools with normal consistency with the Mg-rich formula compared to the infants fed with the control formula (81.8% vs. 41.1%; p<0.001). The number of infants passing one or more stools per day was increased at day 7 in the Mg-rich formula group (86.7% vs. 68.2%; p<0.001). At days 7 and 29, >25% of infants responded completely to the Mg-rich formula compared to <5% of infants fed with the control formula (p<0.001). Parents of infants in the Mg-rich formula group were very satisfied with the treatment (80.8% vs. 10.2%), with the majority willing to continue treatment after 30 days (97.9% vs. 52.6%; p<0.001). Conclusion: The Mg-rich formula significantly improved stool consistency and frequency compared to the control formula in constipated infants.