• Biomolecules & Therapeutics
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• v.3 no.2
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• pp.149-153
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• 1995

Nitric oxide (NO) has been regarded as one of the neurotransmitters of nonadrenergic, noncholinergic (NANC) nerve stimulation in rabbit corpus cavernosum, rat gastric fundus and human intestine. PIANO (photo-induced adequate nitric oxide) is a very useful tool to investige the role of NO in various smooth muscles where NO is a mediator. The present study was undertaken to compare the physiological responses of the rat gastric smooth muscle in response to NANC nerve stimulation and to PIANO. Photolysis of L-NAME, D-NAME and streptozotocin (572) by UV light in the bathing medium caused relaxation of rat gastric fungus that contracted with carbachol, but was resistant to tetrodotoxin (TTX, 1 $\mu$M). Electrical stimulation (20 V, 2~32 Hz, 0.2 msec, 10s) of the gastric fundus, in the presence of atropine and guanethidine, induced frequency-dependent, TTX-sensitive relaxation. Sodium nitroprusside (1 nM-10 $\mu$M), a NO donor, mimicked the relaxations observed after NANC-stimulation or PIANO. Furthermore, PIANO caused UV light exposure time-dependent increase of CGMP in rat gastric fungus strips. These results provide another evidence indirectly that NO is one of the mediators of the NANC inhibitory nerve stimulation in the rat gastric fundus.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.2
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• pp.83-88
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• 2014

Objectives : Vogt-Koyanagi-Harada(VKH) syndrome is a multisystem autoimmune disease characterized by its affects on pigmented tissues in the ocular, auditory, integumentary and central nervous system. This case is to report a decreased optical disc swelling in VKH patient treated only with herbal medication. Methods : A 56-year-old male patient with VKH experienced headache and numbness during 7 months of steroid treatment. He visited our clinic and was administered Haeulsoyo-san (解鬱逍遙散) three times a day for a month. No other oriental or western treatments were included. Result & Conclusions : Patient didn't complain any discomfort during the treatment. Significantly decreased optical disc swelling was confirmed by taking fundus photo. This is the first case of KVH to be reported in Korean medicine society.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.10a
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• pp.793-794
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• 2019

본 시스템은 기존 안저사진의 높은 해상도와 광각 안저사진의 촬영의 편의성과 넓은 시야 각의 장점을 둘 다 취하기 위해, 광각 안저사진을 원본으로 하여 기존 안저사진을 생성하는 작업을 제안한다. 안저사진의 생성 알고리즘은 이미지 생성에 특화된 생산적 적대 신경망(GANs)을 채택하였다. 신경망의 성능을 평가하기 위해, 생성된 안저사진과 직접 촬영한 기존 안저사진으로부터 특성을 추출을 하여 특이점 간의 거리를 측정하고, 이를 바탕으로 두 사진의 유사도를 판단한다.