• Title, Summary, Keyword: hepatoprotective

Search Result 599, Processing Time 0.04 seconds

Phytochemical and pharmacological evaluation of the flowers of Sarcostemma brevistigma Wight

  • Lalitha, KG;Sethuraman, MG
    • Advances in Traditional Medicine
    • /
    • v.9 no.3
    • /
    • pp.252-258
    • /
    • 2009
  • Shade-dried flowers of Sarcostemma brevistigma Wight Syn (SBF) belonging to Asclepiadaceae yielded a rare flavonol glycoside viz., Quercetin 5a prenyl, 3-O-glucosyl, 7-O-(4c-p-coumaroyl) neohesperidoside which were characterized based on chemical and spectral (including 2D NMR) studies. The ethyl acetate fraction of alcoholic concentrate (test sample) of flowers of this plant (SBF) was evaluated for its hepatoprotective and inhibition of lipid peroxidation activities to investigate the scientific basis of the traditional uses. The oral administration in varying doses viz., 125 and 250 mg/kg of aqueous suspension of SBF to rats for 7 days produced significant (P < 0.01) hepatoprotective effect comparable to that of standard drug silymarin. The SBF afforded good hepatoprotection against $CCl_4$ induced elevation levels of serum marker enzymes, serum bilirubin and liver weight. The free radical scavenging effects of SBF and flavonol glycoside (SA) were assigned by $Fe^{2+}$/ascorbate induction method (in vitro), which revealed the inhibition of lipid peroxidation. The SBF and SA showed prominent anti-lipid peroxidation activity ($IC_{50}$ about $\sim$180 mg/ml and 11.0 mg/ml respectively), which was comparable to standard drug curcumin ($IC_{50}$ about $\sim$8.25 mg/ml). Thus the hepatoprotective activity of SB could be correlated to the free radical scavenging property of the flavonol glycoside.

Hepatoprotective and antioxidant effects of Monochoria vaginalis against acetaminophen-induced hepatotoxicity in rats

  • Palani, S.;Raja, S.;Sakthivel, K.;Devi, K.;Kumar, B. Senthil
    • Advances in Traditional Medicine
    • /
    • v.10 no.1
    • /
    • pp.29-36
    • /
    • 2010
  • The present study was aimed to investigate the hepatoprotective and antioxidant activities of ethanol extract from Monochoria vaginalis (250 mg/kg and 500 mg/kg B/W) on acetaminophen (APAP) induced rat hepatic injury. Monochoria vaginalis is a traditional medicinal plant that is commonly used to treat and improve liver conditions in India and other Asian countries. The development of hepatotoxicity induced by APAP is promoted by oxidative stress. APAP treated group significantly (P < 0.01) elevated the serum enzymatic levels like glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase (SALP), total bilirubin and malondialdehyde (MDA), which were restored towards normalization significantly (P < 0.01) thanol extract of yonochoria vagin is (EEMV). In addition, the EEMV significantly (P < 0.01) elevated the decreased level of total protein and antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase and reduced glutathione. Apart from these, histopathological changes also showed the protective nature of the EEMV against APAP induced hepatic damage in liver tissues. The activity of EEMV at 500 mg/kg B/W was comparable to the standard drug silymarin (25 mg/kg B/W). In conclusion, these data suggest that the EEMV possess hepatoprotective and antioxidant effects against APAP-induced hepatotoxicity and oxidative stress in rats.

Hepatoprotective Effects of Water Extract of Liriopis Tuber on Carbon Tetrachloride-Induced Hepatotoxicity in Rats (맥문동 열수추출물의 사염화탄소로 유발된 흰쥐의 간 손상에 대한 보호효과)

  • An, Ji-Yoon;Rhee, In-Ja
    • Korean Journal of Pharmacognosy
    • /
    • v.34 no.2
    • /
    • pp.166-171
    • /
    • 2003
  • The hepatoprotective effects of Liriopis tuber on carbon tetrachloride $(CCl_4)$ intoxicated rats were studied. The water extract prepared from Liriopis tuber were administrated to the pretreatment group orally once a day for successive 7 days, followed by treatment with $CCl_4$ on the seventh day. The post treatment group was treated with $CCl_4$ and then the water extract was administrated. The activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH), and contents of total cholesterol and triglyceride in pretreatment rats serum were significantly decreased compared to the only $CCl_4$ treated rats. The level of high density lipoprotein (HDL) cholesterol was considerably increased compared to the only $CCl_4$ treated rats. In the pretreatment group with the water extract of Liriopis tuber tissue destruction was not observed in light microscopic investigation, compared to the only $CCl_4$ treated rats. These results suggest that Liriopis tuber have potent hepatoprotective effect against carbon tetrachloride intoxicated rats.

Hepatoprotective Effect of Fermented Artemisia princeps PAMPANINI by Lactic Acid Bacteria (발효강화쑥의 간장해 보호효과)

  • Choi, Hyuck-Jae;Kim, Eun-Jin;Han, Myung-Joo;Baek, Nam-In;Kim, Dong-Hyun;Jung, Hae-Gon;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
    • /
    • v.38 no.3
    • /
    • pp.245-253
    • /
    • 2007
  • Artemisia princeps PAMPANINI has been used in traditional medicine of the treatment of inflammatory, liver dysfunction and order disorder in the far east countries including Korea. The present study was carried out to investigate the hepatoprotective effects of ethanol extract of Artemisia princeps (AP) and its fermented agents (AP-F) by lactic acid bacteria derived from human intestinal bacteria on liver injured rat induced by $CCl_4$ and d-galactosamine. Hepatoprotective activity was monitored by estimating serum ALT, AST, ALP, LDH, superoxide dismutase (SOD), glutathione redeuctase (GR) and glutathione peroxidase (Gpx) activities in the liver injured by hepatotoxin. Pretreating rats with AP or AP-F at the same dosage regimen significantly suppressed the acute elevation of serum transaminase, ALP, LDH and GR activities, and significantly increased the lowering of blood SOD and GR activites induced by hepatoxin. Based on these findings, it is presumed that AP and APF may have the hepatoprotective effect on $CCl_4$ and d-galactosamine-induced hepatotoxicity rat.

Hepatoprotective Effects of Aqueous Extract from Aerial Part of Agrimmony (선학초 추출물의 간보호 효과)

  • Kang, Se-Chan;Lee, Chang-Min;Koo, Hyun-Jung;Ahn, Dong-Ho;Choi, Han;Lee, Jae-Hyun;Bak, Jong-Phil;Lee, Mi-Hyun;Choung, Eui-Su;Kawk, Jong-Hwan;Lee, Min-Kyung;Oh, Joa-Sub;Zee, Ok-Pyo
    • Korean Journal of Pharmacognosy
    • /
    • v.37 no.1
    • /
    • pp.28-32
    • /
    • 2006
  • Hepatoprotective effects of an aqueous extract prepared from the aerial part of Agrimonia eupatoria L., a species of agrimmony, were investigated in experimental liver-damaged models. To investigate hepatoprotective effects, the agrimmony extract were fed orally to experimental animals. Thereafter a single dose of hepatotoxin, carbon tetrachloride $(CCl_4)$ or D-galac-tosamine was orally administrated. Chronic liver damage was induced by oral administration of $CCl_4$ for 2 weeks (1 time/day). Hepatoprotective effects were monitored by estimating serum AST and ALT levels. The results showed that the agrimmony extract significantly reduced AST and ALT levels compared with those of control group in both acute and chronic animal models. It was concluded that the agrimmony extract have hepatoprotective effects against rat liver injury induced by $CCl_4$ or D-galactosamine.

Hepatoprotective Effects of Various Enzyme Hydrolysates from Oysters on Tacrine-Induced Toxicity in Human Hepatoma Cells (타크린으로 유발한 간세포 독성에 대한 효소별 굴 가수분해물의 보호 효과)

  • Park, Hye-Jin;Do, Hyung-Joo;Kim, Ok-Ju;Kim, Andre;Ha, Jong-Myung
    • Journal of Life Science
    • /
    • v.22 no.1
    • /
    • pp.117-125
    • /
    • 2012
  • This study investigated the potential hepatoprotective benefits of Crassostrea gigas oyster hydrolysates. Oysters are known to have many biofunctional properties. In particular, oyster enzymatic hydrolysates produce substances with beneficial functions. The potential hepatoprotective effects of C. gigas hydrolysates against damage induced by tacrine were evaluated in vitro in HepG2 cells. Peptides were generated from C. gigas by enzymatic hydrolysis with Neutrase, Flavourzyme, or Protamex enzyme preparations. Tacrine treatment induced considerable cell damage in HepG2 cells, as shown by significant leakage of glutamic oxaloacetic transaminase (GOT) and lactate dehydrogenase (LDH). Cells treated with C. gigas hydrolysates showed an increased resistance to oxidative challenge compared to control cells, as revealed by higher cell survival against tacrine-induced hepatotoxicity. In addition, treatment with C. gigas hydrolysates reduced the leakage of GOT and LDH. These findings indicate that enzyme hydrolysates derived from C. gigas may be of benefit for developing hepatoprotective foods and drugs.

Hepatoprotective, Diuretic and Anti-inflammatory Activities of the Extract from Portulaca oleracea $Linn{\acute{e}}$ (쇠비름 추출물의 간해독, 이뇨 및 항부종 활성)

  • Lim, Jong-Pil;Suh, Eun-Sil
    • Korean Journal of Medicinal Crop Science
    • /
    • v.8 no.3
    • /
    • pp.189-193
    • /
    • 2000
  • Hepatoprotective, diuretic and anti-inflammatory activities of the water extract of Portulaca oleracea were studied. The extract showed 59.4% in s-GPT and 55. 8% in s-GOT compared with sylimarin against $CCl_4$ intoxication and 43.7% diuretic activity compared with furosemide in mice. It showed 61.8% anti-inflammatory activity compared with indomethacin against the carrageenan-induced inflammation in rats.

  • PDF

Hepatoprotective effect of Rumecis Semen

  • Lee, Shin-Seok;Huh, Yeon-Gu;Yim, Dong-Sool;Lee, Sook-Yoen
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • /
    • pp.242-242
    • /
    • 2002
  • The root of Rumex crispus(Polygonaceae) has been used as one of many oriental medicines ofr the treatment of cathartics, juandice and skin diseases etc. Recently, it is reported as one of anticancer agents and a remedy of acute hepatitis in many traditional medicines. Also, the seed of this plant has been used as a folk medicine for the treatment of digestion problems, liver diseases and many sorts of tumors. In this study we have collected the seed of this plant in rural area and investigated the efficacy of hepatoprotective activity from liver cell damage induced by carbon tetrachloride on mice with methanol extracts, ethylacetate and butanol fractions of this plant

  • PDF

Saucerneol B with Hepatoprotective Effect of the Roots of Saururus chinensis

  • Kim, Mi-Hee;Park, Eun-Jeon;Jun, Jung-Yang;Ko, Eun-Kyung;Park, Sung-Eun;Park, Sung-Uk;Sohn, Dong-Hwan;Kim, Youn-Chul
    • Proceedings of the PSK Conference
    • /
    • /
    • pp.263.1-263
    • /
    • 2003
  • In order to find the new hepatoprotective agents from natural products, the isolation and identification of biological active components of the roots of Saururus chinensis has been carried out. A MeOH extract of this plant showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in Hep G2 cells. Five lignans including sauchinone, manassantin A, manassantin B, saucerneol B, and di-O-methyltetrahydrofuriguaiacin B were isolated and identified by spectroscopic evaluation. (omitted)

  • PDF

Hepatoprotective constituents from Beta vulgaris var. cycla

  • Kim, In-Kyum;Chin, Young-Won;Song, Won-Lim;Yang, Hye-Kyung;Kim, Young-Choong;Kim, Jin-Woong
    • Proceedings of the PSK Conference
    • /
    • /
    • pp.259.1-259
    • /
    • 2003
  • In the course of hepatoprotective screening for domestic plants. the aerial parts of B. vulgaris var. cycla exhibited hepatoprotective activity which was determined by using the primary cultures of rat hepatocytes injured by H2O2. Bioactivity-guided separation for this plant gave a new flavonoid (1) and the known compounds (2-4), which structures were elucidated by 1H-NMR, HMQC, 1H-1H COSY and HMBC as compound 1, apigenin 8-C-, 7-O-di-$\beta$-D-glucopyranoside, compound 2, vitexin 2"-O-$\beta$-D-glucopyranoside, compound 3, (+)-dehydrovomifoliol, and compound 4, 3-hydroxy-5$\alpha$, 6$\alpha$-epoxy-$\beta$-ionone.

  • PDF