• Architectural research
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• 제9권2호
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• pp.37-45
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• 2007

The proliferation of the House Dust Mite(HDM) is affected by temperature, humidity, ventilation, etc. Measuring temperature and humidity was performed at the very location where dust samplings take place and where they live in reality together with temperature and humidity of the ambient of the room. There has been discussion over the key environment factor of HDM survival; absolute humidity or relative humidity. It seems that relative humidity is the more important determinant for the mite's survival through the analysis of previous studies. Temperature, humidity, ventilation rate and Der P1 were measured in 4 flats in London. Mite allergen was detected in every house. Levels of Der P1 varied between <100ng/g and 22,778ng/g. Flats with high relative humidity(>50%) and poor ventilation(<0.5ach) showed higher levels of mite allergen than flats with lower humidity and adequate air change rate. Questionnaire survey was conducted and the result helped to confirm the findings from monitoring of environmental factors and the dust sampling.

• Korean Chemical Engineering Research
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• 제43권1호
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• pp.136-139
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• 2005

집먼지진드기에 의한 호흡기 알레르기 질환의 예방 및 치료를 위해 고려할 수 있는 가장 효율적인 방법 가운데 하나는, 항원이 통과할 수 없는 특수 재질의 커버로 직접 침구류를 씌우는 것이다. 따라서 본 연구에서는 특수 커버 사용 후 먼지 양의 감소와 집먼지진드기 allergen 노출에의 감소 정도를 측정하여 특수 커버의 효과를 검증하였다. 본 연구 결과 우리나라의 일반적인 생활환경에서는 특수 커버의 사용이 집먼지진드기 allergen에 대한 노출을 완전히 막아 주지는 못하였다. 그러나 노출되는 양은 감소시킬 수 있었으며 먼지 양이 감소하는 효과도 있었다.

• 한국동물위생학회지
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• 제32권1호
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• pp.87-92
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• 2009

The avoidance of the allergen of the house dust mite is one of the challenges to reduce and treat the symptoms of allergic diseases. Accordingly, various acaricidal agents are being used to kill the mite, but just killing it leaves the remains of it, which still act as the allergen. Therefore expelling the mite is thought as best policy to avoid the mite allergen. For this, some materials have been applied to repellent agents against the mite. Among them, a material with natural origin, known as the phytoncide, is being used for its repellent activity, as well as for its benefits for health. In this experiment, essential oils extracted from Korean white pine (Pinus koreaiensis S. et Z.) and hinoki cypress (Chamaecyparis obtusa), which are widely used as the source of phytoncide products, are studied for demonstration of the repellent effect against the house dust mites, Dermatophagoides farinae and D. pteronyssinus. Direct contact method was used to evaluate the repellent effect (%). And the results suggest the oils have a significant effect enough to be used as a source of repellent agent. For the repellent effect, the most effective concentration was $0.5{\mu}l/cm^2$ at 45 minutes both in the white pine and the hinoki oil.

• 한국대기환경학회지
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• 제22권5호
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• pp.719-723
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• 2006

House dust mite was the most important cause of allergic asthma and rhinitis. More than 70% of Korean children and about 50% of adult with respiratory allergy were sensitive to house dust mite. This experiment was indoor environment in house and house dust mite existence inquiry. From 23rd December 2005 to 28th February 2006, dust samples were collected from the bedclothes by a vacuum cleaner and air sampler And the levels of Der f1 and Der p1 were determined by ELISA((Enzyme-Linked Immunosorbent Assay). The results were as follows : 1 The dust mites allergy contaminations of bedclothes in house were higher than international standards(2000 ng/g). 2. In type of dust mite, the Korean house the almost have the D. farinae other than D. pteronyeeinus of mite. 3. The Der f1 and Der p1 levels per gram of dust from the bedclothes were 2074.99 ng on average, but they did not exist in air. The concentrations of house dust mite were significantly high in the bedclothes. This results suggest that the bedclothes have enough concentrations of dust mites to develop the sensitization. The control of indoor environment should be emphasized to prevent the sensitization by the repeated exposure to dust mite.

• 지역사회간호학회지
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• 제13권1호
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• pp.79-88
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• 2002

Purpose: The purpose of this study was to identify the indoor environment i.e. house type and age, ventilation method, use of bed & sofa, cockroach, ants, etc. on HDM (House dust mites), especially Der fI allergen. Method: Samples of dust from mattresses, pillows and the floor were collected by using a vacuum cleaner from April. 2000. The amount of Group I allergen(Der. fI) of HDM (house dust mites) were measured by two-site ELISA. Indoor Environmental characteristics were accessed by using questionnaires on 178 house wives living in the Seoul area. Results: The amount of HDM allergen (Der fI) was higher in sofa using house. There were higher concentrations of HDM allergen (Der fI) in sofas made from quilt material than for those that were made from leather. Homes that had pets like dogs living in them had higher concentrations of HDM allergen (Der fI) than without dogs. Conclusion: The photophobic mites thrive in dark. warm and humid environments; Items such as pillows. mattresses, box springs, blankets. carpets. and upholstered furniture should be considered ideal environments for the mite. Therefore, an indoor environmental control program should be carried out to avoid the HDM allergen.

• 한국동물위생학회지
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• 제33권2호
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• pp.167-171
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• 2010

Majority of asthma and atopic dermatitis are known to be spontaneously sensitive to house dust mite allergen. Control of house dust mite populations has been principally achieved by using chemical insecticides. But the risk to human health would be a potential problem. Moreover, house dust mite remain as allergens even after death. So, It is more effective method keeping the house dust mites away than killing them. The use of plant-derived repellents has been considered as a promising alternative to chemical repellents. Eucalyptus is a diverse genus of flowering trees in the myrtle family, Myrtaceae. It has insect repellent properties and is an active ingredient in some commercial mosquito repellents. These studies were carried out to investigate repellent effects of Eucalyptus oil against house dust mites and compare lemongrass oil. Eucalyptus oil and lemongrass oil were exposed at different doses (0.2, 0.1, 0.05, 0.025, 0.0125, $0.00625{\mu}l/cm^2$) and different times (1, 3, 6 hours) on house dust mites. The most effective dose of Eucalyptus and lemongrass oils against house dust mites was $0.1{\mu}l/cm^2$ and $0.025{\mu}l/cm^2$. Each repellent effect(%) in most effective dose was 90.3% (Eucalyptus) and 80.8% (lemongrass).

• 대한의생명과학회지
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• 제22권4호
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• pp.211-214
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• 2016

House dust mite is an essential allergen in the pathogenesis of allergic diseases. Abnormal regulation of neutrophil apoptosis is an important pathogenic process in allergic diseases. In the present study, we investigated the effects of house dust mites on spontaneous apoptosis of neutrophils and its associated mechanisms. Extract of Dermatophagoides pteronissinus (DP) inhibited neutrophil apoptosis in a time-dependent manner. Cycloheximide (CHX), an inhibitor of translation, increased apoptosis of DP-treated neutrophils as well as control cells. The pro-apoptotic effect of CHX was blocked by DP in neutrophils. In addition, DP increased the phosphorylation of Bad in a time-dependent manner, indicating that it exerted an inhibitory effect on the function of Bad. These results suggest that DP has anti-apoptotic effects of neutrophils and may regulate protein synthesis and activation of Bad. Moreover, these findings may shed light on elucidation of allergy pathogenesis due to house dust mites.

• 한국환경보건학회지
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• 제31권2호
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• pp.120-126
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• 2005

To assess exposure of allergy patients to a biological environment, measurements were made of levels of airborne bacteria and fungi, house dust endotoxin and mite allergens in homes of 7 allergy patients and 12 healthy families. Concentrations of airborne total bacteria and the ratio of indoor and outdoor concentrations(I/O) in allergy patient's homes were high compared to non-allergy houses. But no significant differences could be shown for the concentration of spores of viable fungi and staphylococcus in indoor air between the homes of allergic patients and healthy families. The results of investigation on house dust mites, Dermatophagoids farinae were detected in all mattress samples and the levels in the allergy patient's homes were generally high, with individual measurements exceeding $2{\mu}g/g$ dust found in $30\%$ samples. In contrast with, Dermatophagoids pteronyssinus were detected in only $60\%$ samples and the concentrations were very low. The levels of endotoxin in dust samples collected from the allergy patient's home mattresses were higher than those of control houses. There was a positive correlation between the endotoxin levels and the house dust mite allergens.

• Korean Chemical Engineering Research
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• 제60권4호
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• pp.557-563
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• 2022

극세 공극 직물의 알레르겐 투과율을 측정하기 위해서는 극세 공극 직물의 공극을 측정하는 편리하고 적절한 실험 장치의 연구 개발이 필요하다. 본 연구에서는 중량 감소율을 측정하여 극세 공극 직물의 공극 크기를 측정하기 위한 간단하고 경제적인 실험 방범을 개발하였다. 또한, 개발된 미세 입자 투과 장치를 사용하여 다양한 직물의 공극 크기를 측정하여 알레르겐 차단 성능을 평가하였다. 본 연구에 의하면 극세 공극 직물의 공극의 크기는 중량 감소 비율을 측정함으로써 구할 수 있었다. 또한 중량 감소 비율의 값은 입자 투과 장치를 통과하는 흡입 압력이 작을수록, 흡입 시간이 길수록 큰 값을 나타났으며, 이 값으로부터 직선 삽입 방법을 통하여 실험 직물의 공극 크기를 측정 할 수 있었다. 개발된 실험 장치 및 방법은 집먼지 진드기 차단 침구에 사용되는 극세 공극 직물에 대하여 그 효과를 검증하는 품질 관리 방법의 실험 기준으로 사용될 수 있을 것으로 기대된다.

• 대한의생명과학회지
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• 제18권4호
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• pp.435-437
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• 2012

House dust mite (HDM) is important in the pathogenesis of allergic diseases including asthma and atopic dermatitis. Dermatophagoides pteronissinus (Dp) is one of major HDM allergens. In this study, we investigated that Dp extract (DpE) affects on the chemotactic activity of monocytes isolated from the peripheral blood. DpE inhibited the migration of human monocytes in response to CC chemokines such as MIP-$1{\alpha}$, RANTES, HCC-4, MCP-1, and TARC. DpE did not alter the expression of CC chemokine receptors (CCRs) such as CCR1, CCR2, CCR3, CCR4, and CCR5. These results indicate that DpE blocks the chemotaxis of human monocytes and its mechanism is not involved in alteration of CCR expression. Better understanding of the effect of DpE on monocytes will enable elucidation of the role of Dp in the development of allergic diseases.