• Title/Summary/Keyword: hypertension

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Sleep Duration and the Related Factors of Hypertension among Korean Middle-aged Adults (우리나라 30~64세 성인의 수면시간과 고혈압 관련 요인)

  • Park, Eunok
    • Korean Journal of Adult Nursing
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    • v.26 no.3
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    • pp.372-381
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    • 2014
  • Purpose: This study investigated the prevalence of hypertension, explored sleep duration, and examined the related factors to hypertension in Korean middle-aged adults. Methods: Using raw data from the Korean National Health and Nutritional Examination Survey (KNHANES) conducted from 2008 to 2010, a secondary analysis was performed with data from 13,230 adults aged 30~64 years. ${\chi}^2$-test and multiple logistic regressions was used for the data analysis. Results: The prevalence of hypertension among Korean middle-aged adults was 21.8% and 40.3% among participants reported that their average sleep duration was below six hours a night. Risk factors for hypertension include: female (the odds ratio (OR) 1.66 for male), 50~64 years age group (OR 3.66 for 30~49 years age group), education level of elementary school (OR 1.84 for university level), low household income (OR 1.27 for upper), obesity (OR 2.41), high risk drinking (OR 1.64), and sleep duration${\leq}6$ hrs (OR 1.16 for 8 hrs of sleep). Conclusion: High risk population of hypertension could be male, aged, low education, and low income. Obesity, high risk drinking, and short sleep duration should be considered as risk factors for hypertension. Interventions for obesity management, adequate alcohol drinking and sleep duration could be considered for preventing hypertension.

A Path Model Predicting Medication Adherence and Self-care of Low-income Older Adults with Hypertension (저소득층 고혈압 노인의 약물복용행위와 자가간호 예측 경로모형)

  • Suh, Soon-Rim;Lee, Eun-Hyun
    • Korean Journal of Adult Nursing
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    • v.23 no.4
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    • pp.374-385
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    • 2011
  • Purpose: The purpose of this study was to identify the factors that influence medication adherence and self-care among low-income older adults with hypertension. Methods: A sample of 297 low-income older adults with hypertension was recruited from June 30 to July 30, 2010. Data collection was done using a face-to-face interview with structured questions. The data were analyzed using descriptive statistics, Pearson's correlation coefficient, and path analysis. Results: Subjective health status, duration of hypertension, number of drugs excluding antihypertensives, body mass index, knowledge about hypertension, sense of coherence, benefit, barrier, and self-efficacy were identified as significant predictors. Subjective health status and duration of hypertension, knowledge, depression, and self-care showed direct effects on medication adherence. Depression had the strongest direct influence on medication adherence. Body mass index, benefit, self-efficacy, and depression showed a direct effect on self-care. Sense of coherence was a strong predictor of depression which significantly influenced on medication adherence and self-care. Conclusion: For enhancing medication adherence and self-care, it is suggested that a psycho-education program reducing depression and increasing knowledge about hypertension should be provided into low-income older adults with hypertension.

The Effect of Systemic Hypertension on the Pediatric Brain (중추신경계에 미치는 소아 고혈압의 영향)

  • Hur, Yun-Jung
    • Childhood Kidney Diseases
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    • v.15 no.1
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    • pp.22-28
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    • 2011
  • Hypertension is one of the most common chronic diseases in childhood and adolescence. Untreated hypertension adversely affects many organs including heart, brain, kidney and peripheral arteries. We reviewed the complication of central nervous system caused by pediatric hypertension. Cerebral blood flows are maintained constantly in response to changes in blood pressure by cerebral autoregulation. Severe hypertension which destructs cerebral autoregulation results in acute hypertensive encephalopathy syndrome, ischemic or hemorrhagic stroke. Chronic pediatric hypertension induces learning disability and cognitive defect which are subclinical symptom prior to brain damage caused by severe hypertension. We should consider the effect of hypertension on pediatric brain because appropriate antihypertensive drugs could prevent these complications.

Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining

  • Lim, Ji Eun;Hong, Kyung-Won;Jin, Hyun-Seok;Oh, Bermseok
    • Genomics & Informatics
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    • v.10 no.4
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    • pp.244-248
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    • 2012
  • Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. In this study, ROS-hypertension-related genes were collected by the biological literature-mining tools, such as SciMiner and gene2pubmed, in order to identify the genes that would cause hypertension through ROS. Further, single nucleotide polymorphisms (SNPs) located within these gene regions were examined statistically for their association with hypertension in 6,419 Korean individuals, and pathway enrichment analysis using the associated genes was performed. The 2,945 SNPs of 237 ROS-hypertension genes were analyzed, and 68 genes were significantly associated with hypertension (p < 0.05). The most significant SNP was rs2889611 within MAPK8 (p = $2.70{\times}10^{-5}$; odds ratio, 0.82; confidence interval, 0.75 to 0.90). This study demonstrates that a text mining approach combined with association analysis may be useful to identify the candidate genes that cause hypertension through ROS or oxidative stress.

Association of PPARGC1A Gene Variants with Hypertension in Korean Population

  • Jin, Hyun-Seok;Park, Sangwook
    • Biomedical Science Letters
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    • v.27 no.1
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    • pp.12-18
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    • 2021
  • Hypertension (HTN) is one of the cardiovascular disease risk factors. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PPARGC1A) is involved in a master modulator of mitochondrial biogenesis, and pulmonary arterial hypertension. In this study, we report results of PPARGC1A were associated with hypertension and its intermediate phenotype of systolic (SBP) and diastolic blood pressure (DBP) in the Korean population. In detail, identifying a susceptibility locus, 3 SNPs for HTN, 2 SNPs for SBP, 3 SNPs for DBP at P<0.05. Among them, rs1472095 in PPARGC1A gene statistically demonstrated one of the significant correlations with Hypertension (P-value=0.00359, OR=0.8, 95% CI=0.68~0.93). The minor allele (T) of PPARGC1A was statistically associated with the increased value of DBP, SBP, and the increase risk of hypertension. We aim to manifest a significant association between genetic variant in PPARGC1A and hypertension. This finding suggested that association of PPARGC1A genetic polymorphism and HTN accelerates our understanding of blood pressure control and underlines potential drug targets for treatment of hypertension.

Effects of Black Ginseng on Hypertension-induced Rats (흑삼이 폐고혈압 유발 흰쥐에 미치는 영향)

  • Song, Nak-Keun;Choi, Hak-Ju;Kim, Dong-Hee;Roh, Seong-Soo;Seo, Young-Bae
    • The Korea Journal of Herbology
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    • v.24 no.4
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    • pp.69-75
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    • 2009
  • Objectives : To access the safety and efficacy of Black Ginseng (BG), a traditional herbal medicine on hypertension, we examined various parameters involved in the pathogenesis of hypertension. Methods : We made deoxycorticosterone acetate (DOCA;25 mg/kg/3times/weeks for 3 weeks)-induced hypertension Sprague-Dawley (SD) rats. And experiment group was treated with extract of black ginseng (BG;200 mg/kg/day). Results : In results, the weight of experiment group treated with BG was increased compared with normal and control group. And the heart and lung weights of experiment group were decreased compared with control group. The blood pressure and pulse rate of group treated with BG were significantly decreased compared with control group. In addition, BG greatly reduced the levels of aldosterone. These results suggested that BG has suppressive effects on hypertension, and BG has potential as a safe and effective therapeutics for hypertension. Conclusions : The present data show evidences on anti-hypertension activity of BG in an experimental animal system, which can provide further insights into the development of anti-hypertension therapeutic agents.

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CACNA1A Gene Polymorphism is Associated with Hypertension in Korean Population

  • Kim, Hye-Kyung;Leem, Kang-Hyun;Lee, Se-Na;Hong, Mee-Sook;Jung, Kyung-Hee;Kim, Su-Kang;Kang, Sung-Wook;Chung, Joo-Ho
    • Biomedical Science Letters
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    • v.15 no.1
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    • pp.31-35
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    • 2009
  • High blood pressure (BP) is the most frequent risk factor among metabolic syndrome components. The control of hypertension is very important to prevent the cardiovascular risk in metabolic syndrome. The dysfunction of calcium channel is responsible in the regulation of the vascular muscle contribution to hypertension. Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit (CACNA1A) gene is located in brain and known to control the intracranial hypertension. In this study, we investigate whether the polymorphisms of CACNA1A gene is associated with hypertension. The 49 CACNA1A genotypes were determined using the Affymetrix Genotyping chip array in 92 hypertension and 279 control individuals from a Korean population. Logistic and multiple regression models were employed to analyze the genetic contributions of polymorphisms. Out of 49 polymorphisms, six SNPs (rs12611029, rs16035, rs7259944, rs10419472, rs17777900, and rs4926294) showed a significant association with hypertension in three alternative models (codominant, dominant, and recessive models; P<0.05 after adjusting for age and sex). Our results suggest that the CACNA1A gene may be associated with hypertension in the Korean population.

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High Blood Pressure-Related Knowledge and Health Behavior among First-Year College Students (일 대학 신입생들의 고혈압관련 지식과 건강행위 이행정도)

  • Jeong, Hye-Sun;Cho, Ok-Hee;Yoo, Yang-Sook
    • Journal of Korean Public Health Nursing
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    • v.23 no.2
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    • pp.285-295
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    • 2009
  • Purpose: This study surveyed first-year college students on their knowledge of hypertension and their health behavior to obtain basic data necessary to develop hypertension prevention and management programs. Method: Subjects were 561 first-year students at a college in Chungcheongbuk-do, Korea. Data was collected using a structured questionnaire during the period from 01 October to 08 December 2007. Data analysis involved t-test, ANOVA, and Pearson correlation coefficient using SPSS for Windows. Results: Of the total subjects, 149 (26.6%) had a family history of hypertension 253 (45.1%) knew their blood pressure, 365 (65.9%) did not measure blood pressure, and 388 (69.1%) were not interested in knowing their blood pressure. Subjects' knowledge related to hypertension averaged 11.54 points out of 22, hypertension-related health behavior averaged 2.31 points out of 4. With a higher score indicative of increased attention paid to healthy behavior. Conclusion: Knowledge of blood pressure and characteristics of hypertension and management of both blood pressure and hypertension can be inadequate in first-year college students. Increased knowledge of hypertension may lead to better health behavior.

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Unmet Health Care Needs and Associated Factors among Patients with Hypertension and Those with Diabetes in Korea (우리나라 고혈압 환자와 당뇨병 환자의 미충족 의료 수준과 관련 요인)

  • Huh, Soon-Im;Lee, Sue-Hyung
    • Health Policy and Management
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    • v.21 no.1
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    • pp.1-22
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    • 2011
  • This study investigated unmet health care needs and associated factors among patients with hypertension and those with diabetes. Patients were identified by medical professionals. Patients who did not take pharmaceuticals to treat their disease(s) were defined as those with unmet health care needs. Using data from 2005 National Health and Nutrition Examination Survey, 3,635 hypertension patients and 1,431 diabetes patients were analyzed. A multivariate logistic regression analysis was employed to examine factors associated with unmet needs. Overall, 16.6% of hypertension patients, 20.3% of those with diabetes presented unmet needs. Common factors associated unmet needs for both hypertension and diabetes were sex, insurance type, self-reported health status and length of disease. Study findings suggest that hypertension and diabetes should be treated in early stage and further study is needed to examine the reasons for unmet needs to improve patient's status effectively.

Health and oral health factors related to hypertension in Korean elderly: analysis of data from the fifth Korea national health and nutrition examination survey(KNHANES 2014) (한국 노인의 고혈압 관련 건강 및 구강건강 요인에 관한 연구: 2014년 국민건강영양조사를 바탕으로)

  • Lee, Kyeong-Hee
    • Journal of Korean society of Dental Hygiene
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    • v.16 no.5
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    • pp.709-716
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    • 2016
  • Objectives: The purpose of the study is to investigate the health and oral health factors related to hypertension in Korean elderly. Methods: The study subjects were 1,527 elderly people${\geq}65$ years old who underwent physical examination and completed the health survey questionnaire of KNHANES 2014. Results: The risk of hypertension was higher in nonsmoking female elderly having poor subjective health status and low body mass index (BMI). The risk of hypertension was also higher in the elderly having poor subjective oral health status and no oral examination in the previous year. Conclusions: Health risk factors for hypertension and oral health factors may be useful measures to manage hypertension and enhance quality of life in the elderly.