• Korean Journal of Acupuncture
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• v.34 no.2
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• pp.82-87
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• 2017

Objectives : Recently the case of lactobacillus mixture culture fluid appliment was reported. In this study, anti-inflamation effects and anti-allergy effects were studied by stimulus of lactobacillus mixture culture fluid extracts in HaCaT cells. Methods : The atopic dermatitis were induced by TNF-${\alpha}$ and interferon-${\gamma}$ in HaCaT cells. TARC/CCL17, MDC/CCL22, RANTES/CCL5 and ROS production were investigated to explain anti-inflamation and allergy effects of lactobacillus mixture culture fluid with cell-enzyme-linked Immunosorbent assay in 450 nm, 485 nm, 535 nm with spectro-fluorometer. Results : The extracts of lactobacillus mixture culture fluid were decreased TARC/CCL17, MDC/CCL22, RANTES/CCL5 expressions and ROS production with a concentration dependent manner. Conclusions : The effects mechanism of Lactobacillus mixed culture fluid for atopic dermatitis symptoms were considered to be explain anti-inflamation and allergy effects via control of cytokine, chemokine and ROS production, and the fluid could be applied in skin cells directly. But classified AD symptom degrees reported in clinical case before as Reaction Period, Reduction Period, Effect Period, Reproduction Period and Rebound Period could not be explained. Further study will be expected.

• The Journal of Korean Physical Therapy
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• v.13 no.1
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• pp.175-188
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• 2001

The purpose of this study was to investigate the effect of the cold air application for release of inflamation and pain in patient with acute rheumatoid arthritis who had taken medication(NSAIDs, DMARDs, corticosteroids). The participants had knee joint pain and ESR score over the 30. They were randomly assigned to three groups with each 15. Control group(group I ) were applied cold air and medication, experimental group II were applied hot pack and medication. and experimental group III were applied only medication. They were evaluated from April 1, 2000 to september 1,2000 ,and it was examined by ESR and VAS(visual analoge scale) in Lee Bang Hoon rehabilitation medicine clinic in Jeju Korea. The result of this study were as follow: 1. It was found that group 1, group II and group III had the statistically significant reduction of the ESR score according to treatment time(p<.05). 2. There were not statistically significant differences in ESR change pattern of each group according to treatment time(p>.05). 3. There were not statistically significant differences in the change of ESR according to treatment time between group I and group II , group I and group III , and group II and group III (p<.05). 4. It was found that group I . group II and group III had the statistically significant reduction of the VAS(Visual Analoge Scale) score according to treatment time(p<.05). 5. There were statistically significant differences in VAS score according to treatment time between control group(group I ) and experimental groups(group II and group III)(p<.05), but there were not stsiistically significant differences between experimental groups(p>.05).

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.475-480
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• 2005

This study is designed to find out the effect of Corydalidis Tuber Carthami Flos Paeoniae Radix Rubra mixed water extract on adjuvant arthritis, and to check the stability for Corydalidis Tuber Carthami Flos Paeoniae Radix Rubra mixed water extract about the liver. At first, rats were devided into four groups; Normal(Non-treated group with FCA), Control(Group administrated saline everyday for 1 week after treatment of FCA), Sample A(group administrated Corydalidis Tuber Paeoniae Radix Rubra Carthami Flos mixed water extract $9mg/200{\sim}220g$ everyday 1 week after treatment of FCA) and Sample B(Group administrated Corydalidis Tuber Paeoniae Radix Rubra Carthami Flos mixed water extract $18mg/200{\sim}220g$ everyday 1 week after treatment of FCA). After then, separated searches were made on the change of edema rate, the number of WBC, the contented quantities of total protein, total bilirubin, GOT, GPT in the serum. Result : In the right planter edema, both of Sample groups showed a decrease with statistical significance in comparison with control group. In the WBC count, Sample B group showed a decrease with statistical significance in comparison with control group and also sample A group showed a decrease, but did not show statistical significance. In the serum total protein, both of samples did not show statistically significant decrease in comparison with the control group. In the serum total bilirubin, GOT and GPT, both of samples did not show any harmful change about the liver in comparison with the control group. According to the above results, it is concluded that Corydalidis Tuber Paeoniae Radix Rubra Carthami Flos mixed water extract had the therapeutic effect of anti-inflammation in adjuvant arthritis with no injury to liver.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.1
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• pp.232-236
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• 2009

Plantar fasciitis is most common cause of heel pain which starts anterior tubercle of calcaneus. It is chronic inflamation of plantar fascia, reduces collagen and water content of heel pain which incur the degenerative changes with elastic fiber weakness. We treated one patient after extracorporeal shock wave treatment. We diagnosed him with X-ray and treated her conservative maneuver as to oriental medical method. We measured Vas(Visual analogue scale) and thermographic picture of both leg. Visual analogue scale is from 10 to 4 and thermographic picture of both leg were improved in cases.

• Journal of Integrative Natural Science
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• v.7 no.3
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• pp.159-165
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• 2014

Pyrazole, hydroxyimino, aldehyde and isoxazole derivatives exhibit a broad spectrum of biological activities such as antimicrobial, anti-inflammatory and antitumor activities. With growing application on their synthesis and bioactivity, chemists and biologists in recent years have considerable attention on the research of these derivatives. In the view of potential importance of these derivatives, we have crystallized few of the derivatives and its report has been published. The present study focuses on docking studies of these derivatives against Phospholipases $A_2$ enzyme. This enzymes has implicated as potential targets for anti-inflammatory drug design. co-crystal structure (PDB ID: 1POE) of $PLA_2$ deposited in Protein Data Bank has been retrieved for docking analysis. Docking studies using Schrodinger's GLIDE reveals that these derivatives shows better binding energy and score in the defined active site. These results may provide a guiding role to design a lead molecule which may reduce inflamation.

• The Korean Journal of Pain
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• v.5 no.1
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• pp.57-62
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• 1992

Bee Venom therapy, as bee honey has long contributed to human life as a valuable fancy food since human history began. It can be found in the literature back up to a thousand years as a form of therapy for management of apin of various origin. Even to the present, there are some physicians and medical personnel who believe in the effects of bee sting therapy throughout the world. However Bee Venom therapy remains somewhat controversial and there are very few controlled studies available to guide clinical practice. We administered apitherapy(Bee venom therapy) against pain of musculoskeletal origin in thirty one patients from october 1988 to october 1990 and got successful results in seventy one percent of patients. Our results suggest that Bee Venom therapy can be one of the methods for conquering pain caused by true inflamation.

• Journal of Integrative Natural Science
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• v.8 no.3
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• pp.204-208
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• 2015

Pyrazole, ${\beta}$-lactam, salicidine, pyren and oxazole derivatives exhibit a broad spectrum of biological activities such as antimicrobial, anti-inflammatory and antitumor activities. With growing application on their synthesis and bioactivity, chemists and biologists in recent years have considerable attention on the research of these derivatives. In the view of potential importance of these derivatives, we have crystallized few of the derivatives and its report has been published. The present study focuses on docking studies of these derivatives against COX-2 enzyme. Docking studies using Schrodinger's GLIDE reveals that these derivatives shows better binding energy and score in the defined active site. These results may provide a guiding role to design a lead molecule which may reduce inflamation.

• Korean Journal of Pharmacognosy
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• v.39 no.3
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• pp.208-212
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• 2008

Seung Ma(升摩) is a famous Chinese crude drug used for treatment of fever, piles and suppurative inflamation. With regard to the botanical origin of Seung Ma, it has been considered to be Cimicifuga spicies of Ranunculaceae, but there has no phrarmacognostical confirmation on it. To clarify the botanical origin of Seung Ma from Korea, the anatomical characteristics of Cimicfuga dahurica, Cimicifuga foetida, Cimicfuga heracleifolia and Cimicifuga simplex were studied. As a result, it was clarified that Seung Ma from Korea was the rhizomes of Cimicifuga dahurica, C, foetida and C, heracleifolia.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.94.2-94.2
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• 2003

CJ-11668 is a new potent and selective COX-2 inhibitor. CJ-11668 showed COX-2 inhibition (IC50) of 65nM and selectivity ratio (COX-l/COX-2) of 770 in the cell based assay. In the human whole blood assay, CJ-11668 showed COX-2 inhibition (IC50) of 370nM and selectivity ratio (COX-l/COX-2), 135. The treatment of CJ-11668 (5 mg/kg, p.o) produced a significant inhibition (35%) of inflamed rat paw volume in the carrageenan-induced acute inflammation. CJ-11668 also suppressed the PGE2 level (69% inhibition, 1 mg/kg, p.o) in the zymosan-induced mouse air pouch model after 3 hrs. (omitted)

• Journal of Pharmacopuncture
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• v.4 no.3
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• pp.119-126
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• 2001

Objective : In order to report the process of treatment of Aplastic anemia by herbal acupuncture Methods: This case was diagnosed as deficiency of Yang of spleen and kidneys, deficiency of Ki and blood, and fevescence from the deficiency of Urn. Hominis Placenta herbal acupuncture and Bee-venom acupuncture were choosen as the method to treat the case. Results: 1. The nocturnal fevescence and indigestion was decreased during the times when Hominis Placenta herbal acupuncture was used once a day. 2. The mobility of the joints was improved and the inflamation on the joints was decreased during the times when Bee-venom acupuncture was used every other day. 3. The interval between the transfusion was extended during the times when Hominis Placenta herbal acupuncture and Bee-venom acupuncture were used by turns. Conclution : Hominis Placenta herbal acupuncture and Bee-venom acupuncture sucessfully imporved the symtoms of patient with Aplastic anemia