• Molecules and Cells
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• v.26 no.1
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• pp.61-66
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• 2008

Cyclic AMP receptor protein (CRP) is allosterically activated by cAMP and functions as a global transcription regulator in enteric bacteria. Structural information on CRP in the absence of cAMP (apo-CRP) is essential to fully understand its allosteric behavior. In this study we demonstrated interdomain interactions in apo-CRP, using a comparative thermodynamic approach to the intact protein and its isolated domains, which were prepared either by limited proteolysis or using recombinant DNA. Thermal denaturation of the intact apo-CRP, monitored by differential scanning calorimetry, revealed an apparently single cooperative transition with a slight asymmetry. Combined with circular dichroism and fluorescence analysis, the thermal denaturation of apo-CRP could be interpreted as a coupled process involving two individual transitions, each attributable to a structural domain. When isolated individually, both of the domains exhibited significantly altered thermal behavior, thus pointing to the existence of non-covalent interdomain interactions in the intact apo-CRP. These observations suggest that the allosteric conformational change of CRP upon binding to cAMP is achieved by perturbing or modifying pre-existing interdomain interactions. They also underline the effectiveness of a comparative approach using calorimetric and structural probes for studying the thermodynamics of a protein.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.1
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• pp.81-97
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• 2012

The objective of this paper is to investigate the 'state of the art' of the interdomain routing protocol BGP. First, BGP is critically reviewed focusing on the BGP policy and decision making process. And then the problems which still remain as open questions are investigated in the areas of 1) protocol stability, 2) traffic engineering and 3) quality of service. The recent research trend to answer the open questions is discussed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.1B
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• pp.86-100
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• 2004

To provide the end-to-end service differentiation for assured services, the random early demotion and promotion (REDP) marker in the edge router at each domain boundary monitors the aggregate flow of the incoming in-profile packets and demotes in-profile packets or promotes the previously demoted in-profile packets at the aggregate flow level according to the negotiated interdomain service level agreement (SLA). The REDP marker achieves UDP fairness in demoting and promoting packets through random and early marking decisions on packets. But, TCP fairness of the REDP marker is not obvious as for UDP sources. In this paper, to improve TCP fairness of the REDP marker, we propose a modified REDP marker where we combine a dropper, meters and a token filling rate configuration component with the REDP marker. To make packet transmission rates of TCP flows more fair, at the aggregate flow level the combined dropper drops incoming excessive in-profile packets randomly with a constant probability when the token level in the leaky bucket stays in demotion region without incoming demoted in-profile packets. Considering the case where the token level cannot stay in demotion region without the prior demotion, we propose a token filling rate configuration method using traffic meters. By using the token filling rate configuration method, the modified REDP marker newly configures a token filling rate which is less than the negotiated rate determined by interdomain SLA and larger than the current input aggregate in-profile traffic rate. Then, with the newly configured token filling rate, the token level in the modified REDP marker can stay in demotion region pertinently fir the operation of the dropper to improve TCP fairness. We experiment with the modified REDP marker using ns2 simulator fur TCP sources at the general case where the token level cannot stay in demotion region without the prior demotion at the negotiated rate set as the bottleneck link bandwidth. The simulation results demonstrate that through the combined dropper with the newly configured token filling rate, the modified REDP marker also increases both aggregate in-profile throughput and link utilization in addition to TCP fairness improvement compared to the REDP marker.

• The KIPS Transactions:PartC
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• v.10C no.3
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• pp.355-366
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• 2003

Today's market share of mobile internet service is growing rapidly in internet due to the rapid advances in wireless mobile networks. To guarantee for QoS of Mobile Nodes in wireless mobile networks, we propose the Proxy MRSVP (PMRSVP) which is efficient resource reservation protocol. The PMRSVP using a modified regional registration restrains excessive message generation from existing protocols that propose an alternative plan of existing best effort service in wireless mobile networks. We show that signaling message generation quantities and resource registration costs of the PMRSVP are lower than MRSVP and Hierarchical MRSVP (HMRSVP) because as Mobile Agent (MA) plays a proxy role instead of Corresponding Host (CH). We evaluate resource reservation cost with registration cost of intradomain and interdomain of the proposed method in the paper by comparing to that of the MRSVP and HMRSVP.

• Journal of KIISE:Computing Practices and Letters
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• v.6 no.2
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• pp.234-243
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• 2000

We design a modified network architecture with condsidering current Internet network model and traffic characteristics, and propose EDCBT(Enhanced Dispersed Core-based Tree) multicast routing protocol, which enhances scalabity, reliability, end-to-end delay and resource utilization EDBCT adopts bidirectional dispersed shared trees and manages both of intradomain and interdomain multicast trees for a multicast group. Each regional multicast tree is estabilshed from its core router and they are interconnected by the operation between border routers on edges of each regional network. As a result, interdomain multicast tree can be easily established. We introduce a new concept named RBTS(Region-based Tree Switching), which dramatically enhances QoS and network utilization. Finally, protocol performance and the effect of core router location are evaluated with MIL3 OPNet network simulator, in terms of end-to-end delay, packet loss and throughput.

• Molecules and Cells
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• v.27 no.6
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• pp.615-620
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• 2009

The plant shoot meristem maintains a group of stem cells that remain active throughout the plant life. They continuously generate new cells that are then recruited for organ initiation in the peripheral zone. Stem cell proliferation and daughter cell differentiation has to be integrated with overall growth and development of the diverse functional domains within the shoot apex. Several studies have revealed extensive communication between these domains. The signaling mechanisms employed comprise diffusible peptides, directional transport of plant hormones, but also complex interactions between transcription factors, that together establish a panoply of regulatory inputs that fine-tune stem cell behavior in the shoot meristem.

• Journal of Photoscience
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• v.7 no.3
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• pp.79-86
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• 2000

Phytochromes are red and far-red light absorbing photoreceptors for photomorphogenesis in plants. The red/far wavelength reversible biliproteins are made up of two structural domains. The light-perceiving function of the photoreceptor resides in the N-terminal domain, whereas the signal transducing regulatory function is located within the C-terminal domain. The characteristic role of the phytochromes as phtosensory molecular switches is derived from the phototransformation between two distinct spectral forms, the red light absorbing Pr and the far-red light absorbing Pfr forms. The photoinduced Pr Pfr phototransformation accompanies subtle conformational changes throughout the phytochrome molecule. The conformational signals are subsequently transmitted to the C-terminal domain through various inter-domain crosstalks and induce the interaction of the activated C-terminal domain with phytochrome interacting factors. Thus the inter-domain crosstalks play critical roles in the photoactivation of the phytochromes. Posttranslational modifications, such as the phosphorylation of Ser-598, are also involved in this process through conformational changes and by modulating inter-domain signaling.

• Journal of Communications and Networks
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• v.3 no.4
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• pp.374-382
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• 2001

Nowadays, the commonly used table lookup scheme for IP routing is based on the sc-called classless interdomain routing (CIDR). With CIDR, routers must find out the best matching prefix (BMP) for IP packets forwarding, this complicates the IP lookup. Currently, this process is mainly performed in software and several schemes hale been proposed for hardware implementation. Since the IP lookup performance is a major design issue for the new generation routers, in this article we investigate the properties of the routing table and present a new approach for IP lookups, our approach is not based Gn BMP and significantly reduces the complexity, thus the computation cast of existing schemes can be significantly reduced. We also propose an efficient IP lookup algorithm, with which we improve the binary search on prefixes to 30 millions of packets per second (MPPS) and 5,000 route updates/s under the same experiment setup with an even larger routing table.

• Journal of the Korean Ceramic Society
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• v.27 no.2
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• pp.169-178
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• 1990

The sintering characteristics of ZrO2 were analyzed in terms of pore microstructure and kinetics of pore elimination. The pore structue of the ZrO2 sample prepared from colloid suspension was characterized by three distinct types of pores ; intradomain, interdomain, and intergglomerate pores. Sintering data at 1600$^{\circ}C$ showed that pores larger than a certain critical size(∼3$\mu\textrm{m}$) were difficult to remove, and this was analyzed in terms of the interagglomerate pore formed from the suspension under the condition of low kinetic stability, that is, the stability ratio smaller than its critical value. A theoretical equation for densification rate was derived and was applied to the densification rate of the ZrO2 polycrystalline body containging both the matrix(the 1st-generation) pores and the interagglomerate (the 2nd-generation) pores under the condition of slow grain growth.

• Proceedings of the Korean Information Science Society Conference
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• 2000.10c
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• pp.573-575
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• 2000

여러 도메인에 결쳐 분포된 멀티캐스트 그룹에게 멀티캐스트 서비스를 제공하는 인터도메인(Interdomain) 멀티캐스트를 지원하기 위하여 IETF에서는 MSDP 방식을 제안하였다. MSDS는 송신자를 기반으로 트리를 구성하기 때문에 수신자는 송신자의 주소를 알고 있어야만 서비스를 받을 수 있는데 진행중인 서비스에 새로이 가입하는 수신자들은 송신자에 대한 정보가 없어서 이 정보를 제공하기 위해서 주기적인 플러딩(flooding) 방법을 사용하고 있다. 이로 인하여 멀티캐스팅의 중요한 성능요소인 확장성이 손상되었다. 이 논문에서는 플러딩을 대신할 새로운 방식으로 On-Demand SA를 제안하였다. 이 방법은 송신자들을 여러 서버에 분산하여 설치하여 멀티캐스트 그룹들은 이 서버에 접속하여 송신자가 누구인지를 확인한다. 이러한 절차는 송신되는 정보량을 줄일 수 있을뿐 아니라 바뀐 송신자의 정보를 멀티캐스트 그룹이 알기까지의 지연시간을 줄여줄 수 있다.