• ETRI Journal
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• 제25권5호
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• pp.297-304
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• 2003

A multimedia SoC often requires a large internal buffer, because it must store the whole search window to reduce the huge I/O bandwidth of motion estimation. However, the silicon area of the internal buffer increases tremendously as the search range becomes larger. This paper proposes a new method that greatly reduces the internal buffer size of a multimedia SoC while the computational cost, I/O bandwidth, and image quality do not change. In the proposed method, only the overlapped parts of search windows for consecutive macroblocks are stored in the internal buffer. The proposed method reduces the internal buffer. The proposed method reduces the internal buffer size to 1/5.0 and 1/8.8 when the search range is ${\pm}64{\times}{\pm}$64 and ${\pm}128{\times}{\pm}$128, respectively.

• JSTS:Journal of Semiconductor Technology and Science
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• 제13권2호
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• pp.157-169
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• 2013

Scale Invariant Feature Transform (SIFT) generates image features widely used to match objects in different images. Previous work on hardware-based SIFT implementation requires excessive internal memory and hardware logic [1]. In this paper, a new hardware organization is proposed to implement SIFT with less memory and hardware cost than the previous work. To this end, a parallel Gaussian filter bank is adopted to eliminate the buffers that store intermediate results because parallel operations allow all intermediate results available at the same time. Furthermore, the processing order is changed from the raster-scan order to the block-by-block order so that the line buffer size storing the source image is also reduced. These techniques trade the reduction of memory size with a slight increase of the execution time and external memory bandwidth. As a result, the memory size is reduced by 94.4%. The proposed hardware for SIFT implementation includes the Descriptor generation block, which is omitted in the previous work [1]. The addition of the hardwired descriptor generation improves the computation speed by about 30 times when compared with the previous work.

• 대한전자공학회논문지SD
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• 제39권5호
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• pp.65-73
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• 2002

본 논문에서는 순차적 입력 데이터 처리방식을 이용하여 2048 point FFT/IFFT를 단일 칩으로 구현하는 방법을 제안하고 검증하였다. 순차적으로 입력되는 2028개의 복소 데이터를 처리하기 위해서는 입력 데이터를 저장하는 버퍼가 필요하고 이 입력 버퍼로는 DRAM 회로를 이용한 지연 변환기 (delay commutator)를 사용하여 전체 칩 면적을 35% 이상 줄일 수 있었다. 전체 FFT/IFFT는 16 point FFT를 기본 블록으로 사용하며, radix-4 구조를 가지는 다섯 단계와 radix-2 구조를 가지는 하나의 단계로 이루어져 있다. 각 단계마다 연산을 수행하면서 증가되는 결과 S/N 비를 유지하면서 비트 라운딩을 하기 위해 convergent block floating point (CBFP) 알고리즘을 적용하여 digital audio broadcasting(DAB)을 위한 단일 칩 설계에 기여하였다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 추계학술대회
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• pp.65-74
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• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• 대한화장품학회지
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• 제47권4호
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• pp.361-368
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• 2021

본 연구는 인체 친화적인 소재로 균을 제거하는 기술을 만들기 위해서 진행하였다. 균총 상호 균형에 중요한 역할을 하는 황색포도상구균이 바이오필름을 생성시킬 때 다양한 농도의 인산염 투입시 나타나는 물성변화를 조사하였다. 원자현미경을 이용해서 인산염 5 mM 처리시 황색포도상구균 바이오필름의 크기와 경도가 통계적으로 유의차가 있게 최소값을 가짐을 관찰하였다. 염료 태깅법으로 흡광도를 관찰한 결과 인산염과 함께 성장한 전체 바이오필름의 농도도 감소한 것을 발견하였다. 이것이 카운터 이온으로서 작용하는 염에 의한 영향인지 확인하기 위하여 소금을 같은 조건에서 처리해보았는데 이때는 바이오필름의 농도 감소가 관찰되지 않았고 이를 통해 인산염이 특별한 생리적인 작용에 관여함을 알 수 있었다. 비행시간형 이차이온 질량분석기를 통해서 이온 검출량을 평가하여 바이오필름 구성성분을 분석한 결과 인산염을 투입하기 전과 후의 모든 바이오필름 외곽에서 세균막만 감지되었는데 특별히 인산염 5 mM에서 이 세균막의 농도가 가장 낮음을 확인하였다. 바이오필름 내부에 어떤 물성 변화가 일어났는지 관찰하기 위해서 시어 응력을 조절하는 유변기기로 바이오필름의 점탄성 특징을 측정을 하니 인산염 5 mM에서 바이오필름의 점도는 변화하지 않았으나 탄성률 감소가 일어난 것을 관찰하였다. 이것을 통해 인산염이 5 mM인 환경에서 균은 내부 탄성률 감소를 통해서 세균막을 탈피시키는 것을 알 수 있었다. 인산염 농도 5 mM에서 관찰되는 세균막 농도 감소는 균이 더 많은 성장을 하기 위해 다른 곳으로 이동하기 쉽게 하기 위해서 스스로 표면에서 탈착하는 것과 연관이 있음을 제시하였다. 마침내 인산염을 투입하면 균의 세균막 제거가 유도되어 결론적으로 황색포도상구균이 쉽게 제거될 수 있음을 밝혀내었다.