• Journal of Radiation Protection and Research
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• v.32 no.1
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• pp.15-20
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• 2007

An empirical formula fur the neutron dose equivalent at the maze entrance of medical accelerator treatment rooms was derived on the basis of a Monte Carlo simulation. The simulated neutron dose equivalents around the Varian medical accelerator by the MCNPX code were employed. Two cases of target rotational planes were considered: parallel and perpendicular to maze walls. Most of the maximum neutron dose equivalents at the doorway were found when the target rotational planes were parallel to maze walls and the beams were directed to the inner maze entrances. The neutron dose equivalents at the outer maze entrances were calculated for about 698 medical accelerator facilities which were generated from the geometry configurations of running treatment rooms, based on such gantry rotation that produces the maximum neutron dose at the doorway. The results calculated with the empirical formula in this study were compared with those calculated by the Kersey method for 7 operating facilities. It was found that the maximum disagreement between the calculation of this study and that of the Kersey method was a factor of 8.54 with the value calculated by the Kersey method exceeding that of this study. It was concluded that the kersey method estimated the neutron dose equivalent at the doorway computed by MCNPX more conservatively than this study technique.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.340-342
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• 2015

윈도우 시스템은 90년대 이후로 지속적으로 사용되어진 개인용 컴퓨터의 운영체제로 그래픽 사용자 인터페이스와 멀티프로세싱 기능 등을 제공한다. 최근 배포되어지는 8.1 버전은 기존의 윈도우 시스템과 비교하여 다양한 특징을 가지고 있지만 윈도우 스토어는 네트워크를 이용하여 설치할 수 있는 다양한 응용 프로그램을 제공한다. 그러나 현재 윈도우 스토어에는 게임을 위한 응용 프로그램은 거의 제공되지 않고 있다. 이 논문에서는 사용자가 간편하게 설치하여 실행시킬 수 있는 미로탈출 앱을 설계한다. 제안한 앱은 저용량으로 윈도우 스토어에서 다운로드해서 사용자가 직관적으로 미로탈출 게임을 할 수 있도록 한다. 이를 위하여 HTML5와 자바스크립트를 이용하여 개발한다.

• Toxicological Research
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• v.16 no.2
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• pp.117-124
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• 2000

The objective of this experiment is to investigate neurobehavioral and developmental effects of fumonisin B1 (FB1) after prenatal FB1 administration in rats. FB1 (0.8 or 1.6 mg/kg) was orally exposed to pregnant rats during gestational days 13 to 20, whereas the vehicle alone was administered to control group. Maternal and offspring body weights, physical landmarks of incisor eruption, eye opening, testes descending and vaginal opening, open field activity, running wheel activity, and complex maze performance were included as endpoints for developmental and neurobehavioral measurement. Maternal body weights were not signfficantly altered after FB1 exposure. Percentage of maternal weight gain difference between control and 1.6 mg/kg FBI groups was about 4%. Pre- and post-weanling weight of offsprings after prenatal exposure to FB1 was not signfficantly changed, suggesting that FB1 at 0.8 or 1.6 kg/kg doses may not cross the placenta. Significant gender difference in running wheel activity on postnatal days 57 to 63 and complex maze performance on postnatal days 75 to 78 was observed.

• Journal of Life Science
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• v.17 no.11
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• pp.1464-1471
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• 2007

Diabetes mellitus is a chronic metabolic disorder, leading to many complications including cognitive deficit. Regular exercise has often been recommended as a therapeutic maneuver to the diabetic patients for the prevention of secondary complications. In the present study, the effects of treadmill exercise on memory and brain-derived neurotrophic factor (BDNF) in the hippocampus of streptozotocin (STZ)-induced diabetic rats were investigated. Male SD rats, aged 6 weeks, were randomly assigned to the following three groups: control group(n=8), STZ-induced diabetic group(n=8), and STZ-induced diabetes and exercise group(n=8). Diabetes was induced by a single injection of STZ (50 mg/kg body weight). Treadmill running was conducted with duration and frequency of 30 minutes and 5 times per week, respectively, for 8 weeks. Memories were tested in the Morris water maze. Western blotting was performed to detect BDNF expression in the hippocampus. In this study, we found that compared to the control group, the STZ-induced diabetes group had a significantly impaired cognitive performance along with suppressed BDNF expression in the hippocampus and the exercise group had a higher cognitive function in diabetic rats. Therefore, the current findings of the study show that a treadmill running exercise can improve diabetes-induced impairment of cognitive function. And the improved cognitive function appears to be related to an alleviation in diabetes-induced BDNF expression in hippocampus.

• The Transactions of the Korea Information Processing Society
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• v.3 no.1
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• pp.43-54
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• 1996

This paper presents new heuristic search algorithms for searching rectilinear r(L1), link metric, and combined shortest paths in the presence of orthogonal obstacles. The GMD(GuidedMinimum Detour) algorithm combines the best features of maze-running algorithms and line-search algorithms. The SGMD(Line-by-Line GuidedMinimum Detour)algorithm is a modiffication of the GMD algorithm that improves efficiency using line-by-line extensions. Our GMD and LGMD algorithms always find a rectilinear shortest path using the guided A search method without constructing a connection graph that contains a shortest path. The GMD and the LGMD algorithms can be implemented in O(m＋eloge＋NlogN) and O(eloge＋NlogN) time, respectively, and O(e＋N) space, where m is the total number of searched nodes, is the number of boundary sides of obstacles, and N is the total number of searched line segment. Based on the LGMD algorithm, we consider not only the problems of finding a link metric shortest path in terms of the number of bends, but also the combined L1 metric and Link Metric shortest path in terms of the length and the number of bands.

• Biomolecules & Therapeutics
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• v.14 no.2
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• pp.83-89
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• 2006

The main aim of this study was to characterize the pharmacological profile of flavonoids utilizing behavioral tests and to investigate how the psychopharmacological activities of wogonin, baicalein and oroxylin A are different. Wogonin, baicalein and oroxylin A were intraperitoneally injected as dosages of 2.5, 5, 10 and 20 mg/kg. In the locomotor activity, Rota-rod test, and elevated plus-maze tests, the behavioral parameters were analyzed by automatic systems. Thiopental induced sleeping time was measured. Water extract of S. baicalensis didn't exhibit sedative effect. Wogonin and bacalein exhibited anxiolytic activity although it was less potent than buspirone. Wogonin and baicalein decreased locomotor activity at a dose of 10 mg/kg. Wogonin also shortened significantly running time on the rota-rod at doses of 5 and 10 mg/kg. Wogonin and baicalein enhanced sleeping at doses of 5 and 10 mg/kg. These results indicate that wogonin produce anxiolysis with sedation and so did bacalein with mild sedation. On the contrary, oroxylin A enhanced running activity on the rotarod and did't depress locomotor activity. Oroxylin A significantly hindered sleeping rather than helped it at doses of 5 and 10 mg/kg. Oroxylin A didn't produce anxiolysis and instead, produce awakening effect. This study demonstrates that wogonin and bacalein exhibited anxiolytic activity with mild sedation, but oroxylin A didn't produce anxiolysis and instead, produce awakening effect. This result indicates that anxiolytic effect without sedation induced by Scutellaria baicalensis is produced by combination of flavonoids.

• Korean Journal of Exercise Nutrition
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• v.23 no.3
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• pp.13-21
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• 2019

[Purpose] Chronic stress is a precipitating factor for depression, whereas exercise is beneficial for both the mood and cognitive process. The current study demonstrates the anti-depressive effects of regular exercise and the mechanisms linked to hippocampal neurogenesis. [Methods] Mice were subjected to 14 consecutive days of restraint, followed by 3 weeks of treadmill running, and were then subjected to behavioral tests that included the forced swimming and Y-maze tests. Protein levels were assessed using western blot analysis and newborn cells were detected using 5-bromo-2'-deoxyuridine (BrdU). [Results] Three weeks of treadmill running ameliorated the behavioral depression caused by 14 days of continuous restraint stress. The exercise regimen enhanced BrdU-labeled cells and class III β-tubulin levels in the hippocampal dentate gyrus, as well as those of thioredoxin-1 (TRX-1) and synaptosomal β2-adrenergic receptors (β2-AR) under stress. In vitro experiments involving treatment with recombinant human TRX-1 (rhTRX-1) augmented the levels of phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2), nuclear β-catenin, and proliferating cell nuclear antigens, which were previously inhibited by U0216 and FH535 (inhibitors of ERK1/2 and β-catenin/T cell factor-mediated transcription, respectively). The hippocampal neurogenesis elicited by a 7-day exercise regimen was abolished by a selective inhibitor of β2-AR, butoxamine. [Conclusion] These results suggest that TRX-1-mediated hippocampal neurogenesis by β2-AR function is a potential mechanism underlying the psychotropic effect of exercise.