• Korean Journal of Plant Resources
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• v.8 no.3
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• pp.319-324
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• 1995

The effect of garlic powder were investigated on health of stamina through mouse test. The swimming time of mouse was measured to determine the effect of garlic powder on stamina. When 2,000 and 200mg/kg of garlic were treated to mouse, swimming times were $124.8\pm61.1$ and $100.4\pm61min$, respectively. Those time were significantly longer than untreated control mouse which showed $67.1\pm15.5min$ of swimming time.

• Journal of Korean Institute of Industrial Engineers
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• v.39 no.3
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• pp.163-171
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• 2013

Various web browsers offer mouse gesture functions because they are convenient input methods. Mouse gestures enable users to move to the previous page or tab without clicking its relevant icon or menu of the web browser. To maximize the efficiency of mouse gestures, they should be designed to match users' mental models. Mental models of human beings are used to make accurate predictions and reactions when certain information has been recognized by humans. This means providing users with appropriate information about mental models will lead to fast understanding and response. A cognitive response test was performed in order to evaluate whether the mouse gestures easily associate with their respective functional meanings or not. After extracting mouse gestures which needed improvement, those were redesigned to reduce cognitive load via sketch maps. The methods presented in this study will be of help for evaluating and designing mouse gestures.

• Investigative Magnetic Resonance Imaging
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• v.12 no.2
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• pp.142-147
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• 2008

Purpose : By using the micro-imaging unit modified from NMR spectrometer, the high resolution MRI protocols of finer than 100 micron in 5 minutes, is sought for mouse, which plays a central role in animal studies Materials and Methods : C57BL/6 mouse, lighter than 50 gram, is used for the experiments. The superconducting magnet is vertical type with 89 mm inner diameter at 4.9 Tesla. The diameter of rf-coil is 30 mm. Mostly used techniques are the fast spin echo and the gradient echo pulse sequence. Results : For 2D images, proton density and T2 weighted images are obtained and their optimum experimental variables were sought. Minute structure of mouse brain can be recognized and 3D brain image is also obtained additionally. 3D image will be useful particularly for the dynamic contrast study using various contrast agents. Conclusion : Like the case of human and other small animals, the high resolution of mouse brain is enough to recognize the minute structure of it. Recently, similar studies are reported domestically, but it seems only a beginning stage. Due to easiness of breeding/control, mouse MRI study will soon play a vital part in brain study.

• Applied Biological Chemistry
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• v.40 no.6
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• pp.490-494
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• 1997

Anticarcinogenic activity of astaxanthin-containing egg yolks (designate AEY) was investigated for benzo[a]pyrene (BP)-induced mouse forestomach tumorigenesis initiating regimen. Female ICR mouse (6-7 weeks of age) were housed in polycarbonated cages (5 mice/cage; 20 mice/treatment) in a humidity-and-temperature-controlled facility and permitted free access to water and food. One week later, four and 2 days prior to p.o. treatment with BP (2 mg/0.2 ml corn oil), mice were given 0.2 ml PBS containing 50 mg AEY, 100 mg AEY, 150 mg AEY, or 150 mg CEY. Control mice were only given 0.2 ml PBS. Three days later this sequence was repeated for a total of 4 times. Beginning with the first intubation and continuing thereafter, body weight and food intake were recorded once weekly. All surviving mice were sacrificed 24 weeks after the first dose of BP. Mice treated with AEY developed only about one third as many neoplasms/animal as mice in control or CEY-treated group (p<0.05). Reduction effect of tumor development by AEY was dependent upon doses applied. Tumor incidence was also reduced by AEY treatments, but significantly reduced only by 150 mg AEY treatment when compared to that by control or CEY. Food intake and body weight were not affected by AEY treatment. These results indicate that AEY inhibits tumorigenesis of mouse forestomach induced by BP.

• Journal of Korea Multimedia Society
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• v.19 no.1
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• pp.60-67
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• 2016

PC users have long been controlling their computers using input devices such as mouse and keyboard. To improve inconveniences of these devices, the method of screen-touching has widely been used these days, and devices recognizing human gestures are being developed one after another. Fox example, Kinect, developed and distributed by Microsoft, is a non-contact input device that recognizes human gestures through motion-recognizing sensors, thus replacing the mouse as an input device. However, when controlling the mouse on a large screen, it suffers from the problem of requiring large motions in order to move the mouse pointer to the edges of the screen. In this paper, we propose a joystick-driven mouse-controlling method which enables the user to move the mouse pointer to the corners of the screen with small motions. The experimental results show that movements of the user's palm within the range of 30 cm ensure movements of the mouse pointer to the edges of the screen.

• Journal of Korean Physical Therapy Science
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• v.19 no.1
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• pp.47-54
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• 2012

Purpose : This study is to know the effect on muscle activity when people use mouse aid or not in computer working environment. Method : 11 people of both sex in their twentieth were tested. As a independent variable, the condition without mouse aid and the condition with movable mouse aid were selected, and as a dependent variable, MVC(%) on four muscles and inconvenience degree(RPE scale) on three body part(wrist, forearm, shoulder) were measured. Result : Analyzing the research, MVC(%) of extensor muscle of finger had notably higher muscle activity than other muscles, and there wasn't notable difference in muscle activity before and after using mouse aid. In case of using mouse aid, we tested by giving RPE questionnaire which segmentalized mental fatigue degree into hand, forearm, and shoulder, and resultingly, there wasn't notable differences perspectively. However, people felt less tiredness subjectively after they use the mouse aid. Conclusion : The usage of mouse aid seems to give comfort to computer users.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.13 no.1
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• pp.44-59
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• 2000

Naetakcheonkeumsan(NCS) was a drug that treated carbuncle and cellulitis. So, the purpose of this Study was to investigate effect of NCS on the anti-cancer and proliferation of lymphocytes in normal mouse group, L1210 cells-transplanted mouse group and anti-cancer drug (vincristine) 0.005mg/kg were injected mouse(Ll210 cells-transplanted) group. We used NCS extract with freeze-dried, 8wks-old male mice, and Ll210 cell lines for this Study, The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results of this Study were obtained as follow ; Group C(NCS plus Rehmanniae Radix Preparat administered group) inhibited proliferaion of lymphocytes in normal mouse group and Ll210 cells transplanted mouse group. Group A(NCS administered group) and Group B(NCS plus Cervi pantotrichum Cornu administered group) inhibited proliferation of Ll210 cells in Ll210 cells-transplanted mouse group and anti-cancer drug were injected mouse(Ll210 cells-transplanted) group. Group C incresed proliferation of L1210 cells in L1210 cells-transplanted mouse group, but inhibited in anti-cancer drug(vincristine) 0.005mg/kg were injected mouse(L1210 cells-transplanted) group.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.184-184
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• 2003

• Environmental Mutagens and Carcinogens
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• v.18 no.1
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• pp.22-25
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• 1998

Anticarcinogenic activity of astaxanthin-containing egg yolks (designate AEY) was investigated for 7,12-dimethylbenz[a]anthracene (DMBA)-induced two stage mouse epidermal carcinogenesis. Female ICR mouse (6-7 weeks of age) were house in a humidity-and-temperature-controlled facility and subjected to feed and water ad libitum. AEY (10 mg/0.2 ml acetone) was painted on the back of mice 7 days, 3 days and 5 min before DMBA treatment (50 nmole/0.2 ml acetone). One week later after DMBA treatment, 6 ${\mu}g$ tetradecanoyl 12-phorbol 13-O-acetate (TPA) dissolved in 0.2 ml acetone was applied on the mouse twice weekly over a period of 22 weeks. No sample was given to control mice. Control egg yolk (CEY) and astaxanthin-containing oil (designate AO) from Phaffia rhodozyma were used as positive controls. Mouse treated with AEY exhibited 10 tumors per mouse whereas control mouse exhibited 15 tumors per mouse, the fact that 33% reduction of tumor per mouse by AEY treatment. Tumor incidence was also reduced to 15% by AEY treatment when compared to that of control group. Such effects were also seen in CEY and AO treatment groups, but leaser extent. AO gave reduction of food intake and body weights relative to those of AEY and CEY, indicating toxicity of AO. These results suggest that AEY exhibits anticarcinogenic activity for DMBA-induced mouse epidermal carcinogenesis.

• YAKHAK HOEJI
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• v.38 no.2
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• pp.166-173
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• 1994

Sex hormones not only regulate external sexual characteristics but several internal biochemical processes. It is well accepted that life-span of female is longer than that of male. Life-span is closely related with aging process in which free radicals are known to be involved. We investigated the effect of testosterone on free radical generating systems and lipid peroxidation based on the sexual difference. Lipid peroxide levels of male and female mouse were increased proportionately with age, especially in male mouse. Increase in enzyme activity of aldehyde oxidase with age was observed in male mouse, while no siginificant change in enzyme activity was found in female mouse. Enzyme activity of xanthine oxidase also showed similar results. It, however, was not significant statistically. Lipid peroxide level and xanthine oxidase type conversion ratio of male and female mouse liver homogenate incubated at $37^{\circ}C$, increased remarkably in proportion to incubation time, especially in male mouse. Lipid peroxide level and aldehyde oxidase activity were measured in normal male mouse, castrated mouse and testosterone treated-castrated mouse. Castrated mouse group showed decrease in lipid peroxide level and aldehyde oxidase activity compared with normal group. Treatment of castrated mouse with testosterone, however turned the level of lipid peroxide and aldehyde oxidase activity back to normal. From the above results, it might be concluded that testosteron could increase the activities of free radical generating enzymes which would result in the formation of lipid peroxide, consequently leading to aging.