• 대한인간공학회지
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• 제31권6호
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• pp.725-731
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• 2012

Objective: The aim of this study is to investigate visual feedback effects and human performance in the foot mouse control. Background: Generally, computer mouse tasks are controlled by visual feedback. In order to understand the characteristics of a foot mouse control, it is important to investigate the patterns of visual feedback involved in foot-mouse control tasks. Human performance of foot mouse control is also an important factor to understand the foot mouse control. Method: Three types of mouse control were determined to investigate visual feedback effects and human performance in the foot mouse control. Visual feedback effects in the foot mouse control were compared with those of a typical hand mouse. The cursor movement speed and mental workload were measured in the three types of tasks and two types of mouses. Results: Mouse control tasks with an element of homing-in to the target were more quickly performed by the hand mouse than the foot mouse. Mental workload was also higher in the foot mouse than the hand mouse. However, in the steering movement, human performance of the foot mouse control was not lower than that of the hand mouse control. Visual feedback in the foot mouse control was less required than in the hand mouse control. Conclusion: The foot mouse was not efficient in the most mouse control tasks, compared to the hand mouse. However, the foot mouse was efficient in the steering movement, moving a cursor within a path with lateral constraints. Application: The results of this study might help to develop the foot mouse.

• 대한인간공학회지
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• 제35권3호
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• pp.175-184
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• 2016

Objective: In this study, two types of foot-controlled mouse devices are compared with a hand mouse in the input tasks requiring repetitively switching between a keyboard and a mouse. Background: Foot-controlled mouse devices have been developed for persons with impairments in the mobility of their hands. However, some researchers insisted that the foot-controlled mouse devices could be effectively used by the persons with no limits to their hand mobility. There are needs to investigate the efficiency of the foot-controlled mouse devices, when they are used by the nondisabled people. Method: Participants conducted the input tasks, requiring repetitive switches between a keyboard and a computer mouse. The used computer mouse devices were two types of foot-controlled mouse and a typical hand mouse. Participants performed three types of input task for five days and three types of task performance were measured; the number of completed input tasks within a given practice time, subjective satisfaction level and the time wasted for the mouse control. Results: For five days, the performance of input tasks sharply increased in input tasks by foot-controlled mouse devices rather than a hand mouse. After five days, the level of satisfaction on the foot-controlled mouse devices approached to about 76% of a hand mouse satisfaction level. The control time of the foot-controlled mouse devices also approached to about 109% of a hand mouse control time. Conclusion: After only five-day practice, the input task performance by foot-controlled mouse devices approached to that of a hand mouse. This result may suggest that the foot-controlled mouse devices can be effectively used as an alternative input device for the nondisabled people, if input tasks are easy and enough practice time is provided. Application: The results of this study might help to design foot-controlled mouse devices and to expend the usage of them.

• Interdisciplinary Bio Central
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• 제2권4호
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• pp.15.1-15.5
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• 2010

RIKEN BioResource Center (BRC) has collected, preserved, conducted quality control of, and distributed mouse resources since 2002 as the core facility of the National BioResource Project by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Our mouse resources include over 5,000 strains such as humanized disease models, fluorescent reporters, and knockout mice. We have developed novel mouse strains such as tissue-specific Cre-drivers and optogenetic strains that are in high demand by the research community. We have removed all our specified pathogens from the deposited mice and used our quality control tests to examine their genetic modifications and backgrounds. RIKEN BRC is a founding member of the Federation of International Mouse Resources and the Asian Mouse Mutagenesis and Resource Association, and provides mouse resources to the one-stop International Mouse Strain Resource database. RIKEN BRC also participates in the International Gene Trap Consortium, having registered 713 gene-trap clones and their sequences in a public library, and is an advisory member of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium which represents major European and international mouse database holders for the integration and dissemination of Cre-driver strains. RIKEN BRC provides training courses in the use of advanced technologies for the quality control and cryopreservation of mouse strains to promote the effective use of mouse resources worldwide.

• 한국HCI학회논문지
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• 제5권2호
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• pp.1-6
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• 2010

본 연구에서는 장애인이나 게이머를 위해 눈의 움직임과 머리의 움직임으로 제어가 가능한 헤드 마우스를 제안하였고, 제안한 마우스를 기존의 마우스와 비교하였다. 마우스 포인터의 이동은 머리 움직임의 회전각도 정보를 활용하였고, 클릭이나 더블 클릭의 이벤트는 눈의 깜빡임을 이용하였다. 기존의 각속도계를 이용한 마우스에서 적분으로 인한 누적오차는 적분을 하지 않고 데드 존을 갖는 비선형 상대 좌표계 방식을 통하여 해결하였고, 추가적으로 이동 거리와 가속도를 함께 고려하여 직관적인 마우스 포인터 제어가 가능하도록 하였다. 주변광의 영향을 최소화하도록 광원 제어 회로를 설계하여 외부 광원의 변화에도 마우스 이벤트 검출에 영향을 받지 않도록 하였다. 제안한 마우스를 응시점을 이용한 마우스(퀵글랜스)와 비교한 결과, 20회 클릭하는 실험에서는 약 21%, Dasher를 이용한 문자입력실험에서도 약 25%, 화상키보드를 이용한 문자입력 실험에서도 약 37% 짧은 입력 시간을 보였다. 그리고 카메라 마우스와의 비교에서도 제안한 헤드 마우스가 우수한 성능을 보였다.

• Journal of Animal Science and Technology
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• 제65권4호
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• pp.767-778
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• 2023

The aim of the research is to identify that porcine oocytes can function as recipients for interspecies cloning and have the ability to develop to blastocysts. Furthermore each mitochondrial DNA (mtDNA) in interspecises cloned embryos was analyzed. For the study, mouse-porcine and porcine-porcine cloned embryos were produced with mouse fetal fibroblasts (MFF) and porcine fetal fibroblasts (PFF), respectively, introduced as donor cells into enucleated porcine oocytes. The developmental rate and cell numbers of blastocysts between intraspecies porcine-porcine and interspecies mouse-porcine cloned embryos were compared and real-time polymerase chain reaction (PCR) was performed for the estimate of mouse and porcine mtDNA copy number in mouse-porcine cloned embryos at different stages.There was no significant difference in the developmental rate or total blastocyst number between mouse-porcine cloned embryos and porcine-porcine cloned embryos (11.1 ± 0.9%, 25 ± 3.5 vs. 10.1 ± 1.2%, 24 ± 6.3). In mouse-porcine reconstructed embryos, the copy numbers of mouse somatic cell-derived mtDNA decreased between the 1-cell and blastocyst stages, whereas the copy number of porcine oocyte-derived mtDNA significantly increased during this period, as assessed by real-time PCR analysis. In our real-time PCR analysis, we improved the standard curve construction-based method to analyze the level of mtDNA between mouse donor cells and porcine oocytes using the copy number of mouse beta-actin DNA as a standard. Our findings suggest that mouse-porcine cloned embryos have the ability to develop to blastocysts in vitro and exhibit mitochondrial heteroplasmy from the 1-cell to blastocyst stages and the mouse-derived mitochondria can be gradually replaced with those of the porcine oocyte in the early developmental stages of mouse-porcine cloned embryos.

• BMB Reports
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• 제43권2호
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• pp.79-90
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• 2010

Mouse models are crucial for the functional annotation of human genome. Gene modification techniques including gene targeting and gene trap in mouse have provided powerful tools in the form of genetically engineered mice (GEM) for understanding the molecular pathogenesis of human diseases. Several international consortium and programs are under way to deliver mutations in every gene in mouse genome. The information from studying these GEM can be shared through international collaboration. However, there are many limitations in utility because not all human genes are knocked out in mouse and they are not yet phenotypically characterized by standardized ways which is required for sharing and evaluating data from GEM. The recent improvement in mouse genetics has now moved the bottleneck in mouse functional genomics from the production of GEM to the systematic mouse phenotype analysis of GEM. Enhanced, reproducible and comprehensive mouse phenotype analysis has thus emerged as a prerequisite for effectively engaging the phenotyping bottleneck. In this review, current information on systematic mouse phenotype analysis and an issue-oriented perspective will be provided.

• International Journal of Control, Automation, and Systems
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• 제5권2호
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• pp.147-154
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• 2007

This paper describes a 'gyro-mouse', which provides a new human-computer interface (HCI) for persons who are disabled in their upper extremities, for handling the mouse-click and mouse-move function. We adopted the artificial neural network to recognize a quick-nodding pattern of the disabled person as the gyro-mouse click. The performance of our gyro-mouse was evaluated by three indices that include 'click recognition rate', 'error in cursor position control', and 'click rate per minute' on a target box appearing at random positions. Although it turned out that the average error in cursor positioning control was 1.4-1.5 times larger than that of optical mouse control, and the average click rate per minute was 40% of the optical mouse, the overall click recognition rate was 93%. Moreover, the click rate per minute increased from 35.2% to 44% with repetitive trials. Hence, our suggested gyro-mouse system can be used to provide a new user interface tool especially for those persons who do not have full use of their upper extremities.

• 한국식품영양과학회지
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• 제29권3호
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• pp.525-530
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• 2000

상품가치가 없는 비상품구로부터 추출한 OWE를 mouse의 피부암 및 위장암 저해 효과에 관한 실험을 한 결과 피부암의 경우 control구에서는 6주부터 종양이 발생하여 23주에는 mouse 당 2.9개의 종양이 발생하였으나 20mg OWE 처리구에서는 8주부터 종양이 발생하여 23주에는 mouse 당 1.3개의 종양이 발생하여 control에 비해 55.2%의 종양 억제효과가 있었다. 20mg quercetin 처리에서는 6주부터 종양이 발생하기 시작하여 23주에는 mouse 당 1.2개의 종양이 발생하였다. 처리별 암 발생율은 20mg OWE 처리에서 85.7%, 20mg quercetin 처리에서는 76.2%의 발생율을 보여 control의 95.2%에 비해 낮은 암발생율을 보였다. 위장암의 경우 control에서는 mouse 당 9.2개의 종양이 발생하였고, 50mg OWE 및 25mg OWE 처리에서는 각 6.1, 6.3개의 종양이 발생하여 control에 비해 각각 33.7%, 31.5%의 종양억제효과가 있었다. 그리고 25mg quercetin 처리에서는 mouse 당 5.3개의 종양이 발생하였다. 처리별 암발생율은 50mg OWE 및 25 mg OWE 처리에서 각 88.2%, 94.1%, 25mg quercetin 처리에서 83.3%의 발생율을 보여 control 100%에 비해 낮은 암발생율을 보였다.

• 대한산업공학회지
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• 제37권3호
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• pp.209-215
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• 2011

The objective of this study was to determine whether there are differences in hand muscle activities (APB : abductor pollicis brevis, ED : extensor digitorum, ECU : extensor carpi ulnaris, and EI : extensor indicis) and subjective discomfort according to the three mouse sizes (small, medium, large) and two task types (pointing and scrolling). The mouse size and task type showed significant interaction effects on the total NEMG (p = 0.004) and on the NEMG of the abductor pollicis brevis muscle (p = 0.001). The total NEMG and the NEMG of APB showed the highest value in the 'scrolling' task using the 'small' mouse. However, the NEMG of the EI was different according to the mouse size, and the 'small' mouse showed the lowest value. The subjective discomfort was the lowest in the 'medium' mouse, and all nine subjects preferred the 'medium' size. The hand-size related anthropometric variables showed different correlations according to the task type and mouse size with the NEMGs and subjective discomfort. The results of this study could be used as a basic information for the determination of the proper mouse size according to the hand size.

• 대한수의학회지
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• 제41권3호
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• pp.293-298
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• 2001

This study was conducted to observe the bone and cartilage formation of mouse fetuses. Mouse litters were sacrificed at pregnant 14th and 18th day and examined for gross skeletal formation using cartilage and bone staining. We identified well developed cartilage formation at the 14th pregnant day in mouse fetus. However mouse fetus at the 14th pregnant day did not show any part of bone formation. At 18th pregnant day, mouse fetus showed well developed body shape and bone and cartilage formation. This results will provide basic information for the evaluation of mouse malfromation and impairment of skeleton formation. Further study will be needed for exact explanation of bone formation from cartilage portion.