• 약학회지
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• 제30권4호
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• pp.174-179
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• 1986

The thymus weight of the mouse was 54.1% in protein malnutritive diet group and 39.2% in group treated with saponin fraction of Panax ginseng in comparison to normal diet group. This decreasing effects of protein malnutritive diet and saponin fraction on the thymus weight practically disappeared after four weeks. The saponin fraction showed no effect on the spleen weight of the mouse. The supplement of the saponin fraction enhanced total peritoneal exudate cells, content of total serum protein and albumin content of the mouse, each 45, 8 and 10% respectively in comparision to that of normal diet group. And these values in protein malnutritive diet group were 61.2, 83.6 and 87.0% respectively in comparision to that of normal diet group, and recovered to the level of normal diet group by the supplement of the saponin fraction. The electrophoregram of the serum protein of the mouse fed with protein malnutritive diet was different from that of the mouse fed with normal diet, but this difference practically disappeared by the supplement of the saponin fraction.

• 한국유전체학회:학술대회논문집
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• 한국유전체학회 2002년도 The 11th Korea Genome Conference
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• pp.41.1-41.1
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• 2002

• 한국환경보건학회지
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• 제21권4호
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• pp.96-101
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• 1995

To study the immunotoxicity of mouse injected with fungal mycotoxin, T-2 toxin (Fusarium mycotoxin) was treated to 6 week-old female C3H/He mouse and the body, organ weight and morphological change were investigated. The weights of body, liver and kidney of mouse injected the 2 mg/kg of toxin was decreased to 17, 20 and 3%, respectively, compared to control animal and the comsumption of feed was also decreased with lapsing the time. The fat dropleting phenomenon and destruction of Golgi apparatus in liver and histopathological changes of tissue and mitochondria in small intestine were found by scanning electron microscopic observation.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.267-274
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• 2014

Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive and efficient tools are required to discover high quality targets and increase the probability of success in the process of new drug development. One such solution to the challenges faced in the development of new drugs and combination therapies is the use of low-cost and experimentally manageable in vivo animal models. Since the 1980's, scientists have been able to genetically modify the mouse genome by removing or replacing a specific gene, which has improved the identification and validation of target genes of interest. Now genetically engineered mouse models (GEMMs) are widely used and have proved to be a powerful tool in drug discovery processes. This review particularly covers recent fascinating technologies for drug discovery and preclinical trials, targeted transgenesis and RNAi mouse, including application and combination of inducible system. Improvements in technologies and the development of new GEMMs are expected to guide future applications of these models to drug discovery and preclinical trials.

• 한국멀티미디어학회논문지
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• 제20권4호
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• pp.671-685
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• 2017

We propose a finger detection algorithm for computer mouse control to control the most commonly actions of a computer mouse(left, right and double click, scroll up and down then we add open and close, minimize and maximize a window, control the mouse.) We use a built-in web camera to control the mouse tasks. We detected, segment, then recognize the hand in our previous papers [1, 2]. The user will be able to interact with the computer with the number of fingers detected.

• The Journal of Korean Physical Therapy
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• 제24권2호
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• pp.57-65
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• 2012

Purpose: This study was to investigate the effect of biomechanical intervention, based on the custom seating system on the activities of a mouse click for children with cerebral palsy. Methods: Thirteen children with cerebral palsy participated in this study. We compared reaction time and frequency for proper mouse click in the subject's typical position, in addition to an intervention position. The intervention position conformed to the principle and practice of research on promoting the upper-extremity movement and postural control. The intervention position was achieved through an external postural support, which was based on the custom seating system. Results: Reaction time and frequency for proper mouse click were moderately improved in the intervention position, compared with that of the typical position. There was a statistically significant difference between the typical position and that of the intervention position (p<0.05). Conclusion: Results provide evidence of the positive effects of functional seating on the activities of a mouse click for children with cerebral palsy.

• 약학회지
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• 제43권6호
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• pp.798-801
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• 1999

To investigate the effect of Artemisia apiacea Hance on the hair growth of black mouse (C57BL/6), this study was carried out. We obtained chloroform fraction, ethyl acetate fraction, butanol fraction from ethanol extract. When these fractions were administered to the black mouse by the method of skin paste, chloroform extract increased remarkably the hair growth of black mouse. thus Chloroform fraction was devided into 5 fractions from 20:1 to 1:1 with chloroform : methanol. the detail fractions of chloroform fraction were administered to the black mouse. We obtained the result that fraction I, II, III, IV are superior to minoxidil of positive control. Most of all fraction II have an dramatical effect on hair growth of black mouse.

• Clinical and Experimental Reproductive Medicine
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• 제28권3호
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• pp.235-245
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• 2001

Objectives: The purpose of this present study was to compare mouse embryo development in 3 commercial media and hatching competence of mouse embryo with or without enzymatic treatment. Methods: Collected 375 mouse embryos were divided into three groups, and then cultured in IVF-20 (G2), Medicult IVF (M3), P-1 (blastocyst M), respectively. Three day mouse morulae were cultured in G2 media treated with pronase. The results were analyzed using Chi-square test, and considered statistically significant when p<0.01. Results: The developmental rate of 2 cell mouse embryo after 72 hours was highest in IVF-20 (G2) among conventional 3 media. The hatching rate of mouse morulae was low when clultured in G2 media without pronase during 48 hours. However, it was higher when cultured in media treated with $1{\mu}g/ml$, $2.5{\mu}g/ml$, $5{\mu}g/ml$ pronase, respectively. Conclusions: Using good media and digestion of zona pellucida with enzymatic treatment improve development and hatching rate of embryo. Therefore, implantation and pregnancy rate could be improved.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.105-105
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• 2003

In previous reports, pVPSV.IGR2.1 transgenic mouse were described that brain tumor and lymphoma by reason of Vasopressin-SV40 T antigen. In this study, we produced pVPSV.IGR3.6 transgenic mouse that used pVPSV.IGR3.6 vector. Expression of transgene was vary different in transgenic mouse. We obtained 6 transgenic mouse line, moreover they had died at the age of 2-6 weeks without transmitting the transgene to their offspring, and had tumorigenesis on same location with pVPSV.IGR2.1 transgenic mouse. Only a founder mouse was investigated for expression of fusion gene. Here we extended this transgenic approach to the study of tumor progression. From the mouse, we confirmed brain tumor cell, after then cultured for investigate characterization. In this report, we demonstrate that reduction of survival rate in transgenic mouse fused vasopressin gene length, acquisition of brain tumor cell, composition with astrocyte cells and neuronal cells. Finally, cells had no change with increase of passage.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 1부
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• pp.337-341
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• 2008

본 논문에서는 핀형 진동촉각 디스플레이 장치와 자이로스코프 칩을 이용한 진동 촉각 공간 마우스를 제시한다. 이 마우스는 자이로스코프 칩을 이용하여 공중에서 동작하는 공간마우스에 본 연구실에서 자체 제작한 진동촉각 디스플레이 모듈을 통합하여 위치 입력과 진동 촉각 출력이 동시에 가능한 새로운 형식의 인터페이스 장치이다. 최근 진동촉각 디스플레이의 소형화, 저전력 소모 방향으로의 발전으로 인해 마우스나 모바일 장치 등 소형 임베디드 환경에서도 사용이 가능하게 되었다. 또한 MEMS 기술로 인한 자이로스코프나 센서 기술의 발전으로 인해 이젠 마우스 같은 소형화 제품에도 소형 자이로스코프 칩을 이용하여 평면 환경이 아닌 공간상에서 사용 가능한 마우스를 제작할 수 있게 되었다. 이 진동 촉각 마우스는 자이로스코프 칩을 이용하여 손의 동작을 인식하고 그 데이터를 블루투스 통신을 통해 PC에 전달하여 포인터를 이동시킨다. 또한 마우스와 손가락의 접촉 부위에는 $2\;{\times}\;3$의 핀형 진동촉각 디스플레이 장치가 장착되어 PC 어플리케이션 상에서 포인터 위치에 따른 흑백 이미지 정보를 제공하거나 문자를 점자로 출력시켜 주는 등 진동 촉각을 통한 정보 전달을 가능하게 해준다.