• Electronics and Telecommunications Trends
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• v.36 no.5
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• pp.9-20
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• 2021

A technology to replace the traditional blood sampling method for glucose monitoring has been sought for a long time. It is now possible to measure the blood glucose change rate continuously for more than 24 hours using a minimally invasive method that does not involve blood collection. Furthermore, various technology development efforts are being made for innovative diabetes management through intermittent or continuous blood glucose monitoring in a non-invasive manner. In this paper, we present an overview of diabetes and the need for continuous blood glucose measurement techniques., and then introduce various non-invasive blood glucose measurement techniques currently being studied. In addition, through research and analysis of the recent commercialization development status of minimally invasive, non-invasive, and wearable continuous blood glucose measurement technologies, we examine global development trends of future technologies.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.7
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• pp.1263-1271
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• 2001

There are two methods in blood pressure measurement ; Invasive methode and Non-invasive method. The Invasive methode can get the 띠cod pressure measurement but, patient feel uncomfortable. So Non-invasive methode used generally. The Oscillometric method is typical Non-Invasive method. This method is commonly used to measure BP in electric sphygmomanometer and has various algorithm. In this paper it is described about a algorithm, it controls, determinates the cuff pressure, and fillers the measured BP data. This system can interface with PC(personal computer) by RS-232 and save the measured data in PC. This system deflates the cuff pressure by Solenoid valve. The main algorithm are oscillometric and maximum amplitude algorithm(MAA). MAA has various measured oscillation, it depends on patient's age, height, weight and arm circumference size. In this paper proposed system can measure Systolic BP, Diastolic BP, and Mean BP using Interpolation, Auto Reinflation algorithm.

• YAKHAK HOEJI
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• v.48 no.3
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• pp.177-181
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• 2004

Non-invasive blood glucose measurement from mouse tail was performed by near-infrared (NIR) spectroscopy. Three groups; normal, type I diabetes (insulin dependent diabetes mellitus, IDDM), type II diabetes (non-insulin dependent diabetes mellitus, NIDDM) group, were studied over a 10 weeks period with the collection of near-infrared (NIR) spectra. Spectral variations from long-term measurement (10 weeks) from dramatic and nonlinear changes in the optical properties of the live tissue sample were compensated by chemometrics techniques such as principle component analysis (PCA) and partial least squares (PLS) regression. The effect from mouse body temperature changes on NIR spectral data was also considered. This study showed that the compensation of variations from long-term measurement and temperature changes improved calibration accuracy of non-invasive blood glucose measurement.

• Proceedings of the Optical Society of Korea Conference
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• 2009.02a
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• pp.537-538
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• 2009

• Biomedical Science Letters
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• v.21 no.3
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• pp.135-143
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• 2015

Electrocardiogram measures the electric impulses generated by the heart during its cycle. Recently genome-wide association studies on electrocardiogram traits revealed many relevant genetic loci. Therefore, these findings need to be validated and investigated to determine the underlying mechanisms using mouse models. Invasive radiotelemetry has been widely used to record the electrocardiogram in mice because it has several advantages over non-invasive measurements. However, radiotelemetry is expensive and requires complicated surgery. On the other hand, a non-invasive method using 3 electrodes (one for earth) for lead II is easy to establish and allows for rapid measurement. In this study, eleven mice were measured with this non-invasive method and no statistical difference among them was found in any ECG measurements. In addition, repeat measurement in the same mouse was performed in 9 sets of experiment and the results indicated that non-invasive method was reliable for reproducibility. Further it was shown that measurements for 1, 5, 10, and 15 minutes were not different so that a short recording such as 5 minutes was enough to estimate the ECG values including heart rate. Further this method was validated by measuring the ECG of Balb/c and FVB that were previously shown to differ in ECG values by radiotelemetry. Significant differences were found in heart rate, PR interval and corrected QT interval between these mouse strains. This study partially proved that non-invasive method also could provide the accuracy and reproducibility. Based on these results, the non-invasive ECG recordings of lead II is recommended as a useful method for quick test in mouse model.

• YAKHAK HOEJI
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• v.46 no.5
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• pp.331-336
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• 2002

The purpose of this study is to develop a non-invasive blood glucose measurement method by a portable near infrared (NIR) system which was newly integrated by our lab. The portable NIR system includes a tungsten halogen lamp, a specialized reflectance fiber optic probe and a photo diode array type InGaAs detector; which was developed by a microchip technology based on the lithography. Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were recorded by using a fiber optic probe. The spectra were collected over the spectral range 1100 ∼ 1740 nm. Partial least squares regression (PLSR) was applied for the calibration and validation for the determination of blood glucose. The calibration model from earlobe spectra presented better results, showing good correlation with a glucose oxidase method which is a mostly used standard method. This model predicted the glucose concentration for validation set with a SEP of 33 mg/dL. This study indicated the feasibility for non-invasive monitoring of blood glucose by a portable near infrared system.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.289.1-289.1
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• 2003

Three types of near infrared spectrometer, a photo diode array type, a dispersive type and a FT type, were evaluated and compared the systematic difference in blood glucose measurement. The fundamental study was performed by adding glucose to buffer solution and bovine blood as the preceding study of non-invasive blood glucose. Spectra were collected using a 1.0 mm optical pathlength quartz cell by transmittance method. (omitted)

• Journal of Sensor Science and Technology
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• v.28 no.5
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• pp.305-310
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• 2019

The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishing the concentrations of HbA1c control solutions at 5%, 7%, and 9%.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.12
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• pp.1567-1572
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• 2004

Although accurate measurement of velocity profiles, multiple velocity vectors, and shear stress in arteries is important, there is still no easy method to obtain such information in vivo. This study shows the utility of combining ultrasound contrast imaging with particle image velocimetry (PIV) for non-invasive measurement of velocity vectors. The steady flow analytical solution and optical PIV measurements (for pulsatile flow) were used for comparison. When compared to the analytical solution, both echo PIV and optical PIV resolved the steady velocity profile well. Error in shear rate as measured by echo PIV (8%) was comparable to the error of optical PIV (6.5%). In pulsatile flow, echo PIV velocity profiles agreed well with optical PIV profiles. Echo PIV followed the general profile of pulsatile shear stress across the artery but underestimated wall shear at certain time points. These studies indicate that echo PIV is a promising technique for the non-invasive measurement of velocity profiles and shear stress.

• Journal of IKEEE
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• v.24 no.3
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• pp.713-718
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• 2020

The method of measuring skin active points is a technique for obtaining a lot of biometric information because it is measured with convenience, low cost and non-invasive methods. In this paper, we used in a three electrode measure method that has the advantage of measuring the impedance of the APs under the skin. The impedance measuring method is well illustrated by a simple model of an equivalent electrical circuit that correlates well with experimental results. The characteristic frequencies of APs are about 15-30HZ higher than that of surrounding skin and the values of measured reactance are about 35-77KΩ smaller. This technology analyzed accurately and objectively the reactance and characteristic frequency of APs and the surrounding skin using a non-invasive measuring system.