• Title, Summary, Keyword: obesity

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High Food Efficiency Ratio of Prepubertal Growth Period Leads to a Long-Term Susceptibility for Obesity and Insulin Resistance in Obesity-Prone and Obesity-Resistant Sprague Dawley Rats

  • Choi, Joo Sun
    • The Korean Journal of Food And Nutrition
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    • v.30 no.4
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    • pp.830-840
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    • 2017
  • Excessive body weight gain during the growth period of early life may predispose individuals towards obesity and metabolic disorder in later life. We investigated the possibility of using the food efficiency ratio as an early indicator for predicting susceptibility to diet-induced obesity and insulin resistance. Four-week-old, prepubertal, male Sprague Dawley rats were divided into obesity-prone and obesity-resistant groups based on food efficiency ratio values after five days on a high-fat diet. Metabolic parameters measured after 2, 6, and 10 weeks, and specific phenotypes were compared with each group. Obesity-prone rats had higher increases in body weight and fat mass compared to obesity-resistant rats over the study period. Obesity-prone rats became glucose intolerant early in this study and remained so throughout the experimental period, with increases in fat weight and leptin levels occurring first, followed by increases in insulin level. Gluconeogenesis and insulin resistance significantly increased in obesity-prone groups in which activities of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase were increased and glucokinase activity decreased. Higher food efficiency ratio at an early age was closely correlated with body fat accumulation, hyperleptinemia, and hyperinsulinemia of middle and elderly age. We suggest a high food efficiency ratio in prepubertal subjects may be a useful predictor of future obesity and insulin resistance.

Development of Manual for Standard Counseling of Obesity Patients in Korean Medicine (한의 비만 표준 상담 매뉴얼의 개발)

  • Chung, Won Seok;Kim, Koh Woon;Jo, Jun Young;Kim, Hojun
    • Journal of Korean Medicine for Obesity Research
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    • v.19 no.2
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    • pp.113-118
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    • 2019
  • A counseling manual for the standardized management of obesity in Korean Medicine was developed. Four specialist for obesity and ten advisors participated in the development. The development process was conducted in order to investigate the needs of clinical doctors for obesity, search for related books and references, determine the contents of the manual, produce the manual, and review of the advisors. The contents of the manual were written in order of goal of obesity counseling, assessment of obesity and health risk factors, assessment of obesity-related lifestyles, counseling for weight management, and counseling for Korean Medical treatment. This manual is the first standardized counseling manual developed, and it is meaningful to provide a counseling method for comprehensive Korean Medicine obesity care. Although there were various limitations in the review of the advisory committee, it is expected that this study will be used as a basic data for the establishment of obesity-related health care policy. We hope that obesity counseling of Korean Medicine will be settled as one of the certified korean medical treatment.

Study on an Actual Condition and Relevant Factors of Obesity of Elementary School Students (초등학교 아동의 비만 실태 및 관련요인 -대구시 일 초등학교 고학년을 중심으로-)

  • 이종렬;박천만
    • Korean Journal of Health Education and Promotion
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    • v.21 no.2
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    • pp.35-54
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    • 2004
  • This study was intended to provide basic data of nutrition education to a prevention of obesity and living patterns of elementary school students. Through the measurment of the actual obesity rate of children for students who were in the fifth and sixth grades of elementary school as well as their mothers, and by analyzing obesity-related factors. Children have started to have the characteristics obesity and obesity problems. 1. There were total 234 children including 133 boys (56.8%) and 101 girls (43.2%) for the study. There were 80 children in the fifth grade (34.2%) and 154 children in the sixth grade (65.8%). 2. Among the subjects 20.1% were obese. By gender, the obesity rate of boys (27.1%) was higher than that of girls (l0.9%)(p<0.01). By grade, children in the fifth grade (26.3%) had higher obesity rate than children in the sixth grade (l6.9%)(p<0.05). 3. In terms of the educational level of parents, the obesity rate of children of parents who received university and/or higher education was 27.5% (p<0.05). 44.1% of parents answered ‘I almost never give snack’s’(p<0.01). 4. There was 32.8% for an irregular quantity of meal. There was no obese child who under-ate (p<0.05). In terms of impulse eating, ‘I eat.’ and ‘I don't eat.’ were 24.4% and 25.9% respectively. The obesity rate of the case of ‘I eat only food I like.’ was 10.6% (p<0.05). In terms of the obesity rate based on the daily average meal frequency, there was the highest rate of 26.1% for I average meal frequency per day, 13.0% for 2 daily average meal frequency, and 7.4% for over 3 average meal frequency per day (p<0.05). For a degree of a physical activity, the group of active physical activity (p<0.05) and the group which liked the physical exercise showed a lower obesity rate (p<0.001). The obesity rate of children who had regular exercise was 11.8%. It was lower than the obesity rate (24.8%) of children who didn't exercise (p<0.01). The higher exercise frequency per week was, the lower the obesity rate was(p<0.01). In terms of the exercise time, there was 8.3% for over 60 minutes and 28.9% for less 15 minutes. The group which had the long exercise time showed a lower obesity rate(p<0.05). As the result, the education for obesity must enable students to recognize the warning signs for obesity and control their own weight with proper living patterns, by modifying behaviors considering the degree of obesity. Obesity must be controlled by the prevention and education connected with the family for all students as one of the school health programs. There must be also the development of a program through individual consultation considering the degree of obesity.

Evaluation of Obesity from BMI and Waist Circumference, and Its Relation with Cardiovascular Risk Factors (건강검진 수진자들의 비만유형과 관상동맥질환 위험인자와의 관련성)

  • Cho, Ju-Yeon;Park, Jae-Yong;Han, Chang-Hyun
    • Korean Journal of Health Education and Promotion
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    • v.25 no.2
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    • pp.47-59
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    • 2008
  • Objectives: The objective of this study was held for prevention of coronary artery disease and improvement of health of local community residents by classifying the obesity types of their waist circumference and BMI, and appraising the coronary artery disease risk factors(CRF). Methods: We analyzed the data on the 1,914 adult cases (1,156 male and 758 female) during Nov, 2006 to Mar. 2007 on a general hospital in Daegu city, Korea. The obesity types in this research were classified into normal group, seeming obesity group, abdominal obesity group and obesity group. Also, CRF was classified by normal, mild, moderate, and severe, and each class was given the index from 0 to 3. The coronary artery disease risk factors index(CRFI) was defined as the sum of index, and we defined that if the sum is higher, higher chance of coronary artery disease risk exist. Results: According to the research, by the age group, normal group has higher percentage in age 30 to 40, and obesity group and abdominal obesity group has higher percentage in age 50 to 60. CRFI is increased by order of normal group, seeming obesity group, abdominal obesity group, and obesity group on both male and female groups, and male shows higher index than female on all four groups. CRFI will be influenced by order of obesity group, seeming obesity group, and abdominal obesity group on male, and obesity group, abdominal obesity group, and seeming obesity group on female according to the result of multiple regression between obesity type and CRFI. Conclusion: According to the result from our research, we have to have keen attention to not only seeming obesity group and obesity group, but also abdominal obesity group which has normal waist circumference influence to CRFI. So, those kinds of indexes have to be controled by controling their weight. Also, we believe that health behaviour can improve and CRF can be prevented by the early health care and early health education to those with no abnormal indication on clinical indicator but with abnormal BMI and waist circumference.

The Health-related Quality of Life of Obesity (비만과 건강관련 삶의 질)

  • Kwon, Young-Dal
    • Journal of Korean Medicine for Obesity Research
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    • v.4 no.1
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    • pp.125-137
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    • 2004
  • Objective: The purpose of this study is to investigate how to use the Quality of Life(QoL) of obesity and to study the report cases which measure QoL on obesity. Method: This study investigate the definition of Health-related Quality of Life(HRQoL), the measurement of Health-related Quality of Life, and the papers of Health-related Quality of Life on obesity through the books and medicine journals of HRQoL and obesity. Conclusions: 1. The QoL includes role functional ability, the degree and quality of social and community interaction, psychological state, somatic feeling, and life satisfaction than personal health and social well-being. 2. The investigator needs to evaluate the reliability, validity and sensitivity of the scale, and the appropriateness of the instrument for the target population When he decides measurement. 3. The investigator have the well-drilled supporter or himself managed the data and study population to prevent missing data. 4. The investigator should decide which is needed on obesity a obesity-specific or broad-ranging instrument, or both.

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Adolescents' health behaviors and obesity: Does race affect this epidemic?

  • Dodor, Bernice A.;Shelley, Mack C.;Hausafus, Cheryl O.
    • Nutrition Research and Practice
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    • v.4 no.6
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    • pp.528-534
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    • 2010
  • This study explores the influence of health behaviors and individual attributes on adolescent overweight and obesity using data from Wave II (Add Health). Structural equation model/ path analysis using maximum likelihood estimation was utilized to analyze the relationships of health behaviors and attributes with obesity. Results of the model reveal that the causal paths (adolescents' attributes and health behaviors) for overweight and obesity were different for African American and Caucasian adolescents. Generally, African Americans were more susceptible to overweight and obesity than Caucasians. Although increasing levels of vigorous physical activities lowers the risk for obesity among African American and Caucasian adolescents alike, low family SES and being sedentary were associated with overweight and obesity among Caucasians. No significant associations were found among African Americans. Increased hours of sleep at night relate positively with obesity among African Americans. These findings suggest important elements in the consideration of race in developing effective intervention and prevention approaches for curbing the obesity epidemic among U.S. adolescents.

Recent Advances in Anti-Obesity Agents (비만 약물 치료의 최신 지견)

  • Kim, Min Kyung;Kim, Chul Sik
    • The Korean Journal of Medicine
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    • v.93 no.6
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    • pp.501-508
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    • 2018
  • Obesity is a chronic disorder that is a significant risk factor for diabetes, cardiovascular diseases, malignancy, and other chronic diseases. Lifestyle modifications form the basis of most treatments for obesity, but it has become clear that such modifications alone are not enough for many obese patients. When a behavioral approach is insufficient, pharmacological treatment may be recommended. In recent years, the US Food and Drug Administration (FDA) has withdrawn several therapeutic options for obesity due to their side effects, but has approved four novel anti-obesity agents. Until recently, orlistat was the only drug approved for the management of long-term obesity, but the US FDA approved the novel anti-obesity drugs lorcaserin and phentermine/topiramate in 2012, and naltrexone/bupropion and liraglutide in 2014. The present review discusses the different pharmacotherapeutic options for the treatment of obesity.

Effects of Exercise on Cardiovascular Disease Risk Factors in Sarcopenic Obesity Elderly Women (규칙적인 운동이 sarcopenic 비만여성고령자의 심혈관질환 위험인자에 미치는 영향)

  • Jung, Joo-Ha;Yang, Seung-Jai
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.9
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    • pp.3962-3972
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    • 2012
  • The purpose of this study was to analyze the effects of combined exercise on body composition and cardiovascular disease risk factors in sarcopenic obesity elderly women. The subjects for the study were 21 obesity elderly women over 65 years old. They were divided into two groups, the sarcopenic obesity group(n=9) and non-sarcopenic obesity group(n=12). The variables of body composition and CVD risk factors were measured in all the subjects before and after 16-week combined exercise. The findings of this study were as follows; In the sarcopenic obesity elderly women significantly decreased total cholesterol(TC), triglyceride(TG), and left baPWV. The non-sarcopenic obesity elderly women significantly decreased total cholesterol(TC), triglyceride(TG), low density lipoprotein-cholesterol (LDL-C), and left baPWV, but significantly increased high density lipoprotein-cholesterol(HDL-C). The most important finding in this study was that sarcopenic obesity elderly women showed delayed effects of a 16-week combined exercise on HDL, LDL-C, BP, and right baPWV compared to the non-sarcopenic obesity elderly women.

Anti-Obesity Drugs: A Current Research Insight

  • Son Eun-hwa;In San-Whan;Kim Byung-Oh;Pyo Suhkneung
    • Biomedical Science Letters
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    • v.11 no.2
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    • pp.89-101
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    • 2005
  • Obesity is increasing worldwide and has become a major health burden in Western societies affecting every third American and every fifth European. Obesity makes a major contribution to morbidity and mortality, predisposing individuals to cardiovascular disease and diabetes. Many new substances are currently being investigated for their usefulness in the pharmacotherapy of obesity. Most anti-obesity drugs can be divided into four groups: those that reduce food intake; those that alter metabolism; those that increase thermogenesis; and those that regulate hormone involved in feeding behavior. In this article we review these and other agents available in various countries for the treatment of obesity. Perhaps more importantly, we have focussed on areas of potential productivity in the future. Over the last 5 or so years, this impetus in obesity research has provided us with exciting new drugs targets involved in the regulation of feeding behavior and cellular mechanism involved in energy expenditure. Recent development in the quest for control of human obesity include the discovery of hormones, neuropeptides, receptors and transcription factors involved in feeding behavior, metabolic rate and adipocyte development. For developing new, perhaps even more specific pharmacological agents, further research is needed to understand the individual different genetic and physiological basis of obesity. It remains the hope of research scientists that in the not too distant future we shall see a new class of anti-obesity drugs arising logically from the molecular biology revolutions.

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Development of a Web-Based Obesity Management Program for Elementary School Students (초등학생을 위한 웹기반 비만관리 프로그램 개발)

  • Lee, Hae Sun;Park, Jeong Sook
    • The Journal of Korean Academic Society of Nursing Education
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    • v.19 no.2
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    • pp.215-227
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    • 2013
  • Purpose: The purpose of this study is to develop a 12-week web-based obesity management program for elementary school students and to evaluate the appropriateness of the developed program from experts and users. Methods: The development of a web-based obesity management program proceeded through the stages of analysis, design, development, and evaluation. After the application of the web-based obesity management program, the evaluation of appropriateness were conducted for knowledge of obesity, obesity control behavior and satisfaction of the program. Collected data has been analyzed using SPSS 19.0. Results: The name of the program developed by this study is healthful weight management and its URL is http://ihealth.or.kr. There were 6 major menus and 18 sub menus including diet, exercise and behavior modification in this program. This study showed that this web-based obesity management program had high satisfaction for a system and increase knowledge of obesity and obesity control behavior for obese children. Conclusion: We expect the web-based obesity management program for elementary school students developed by this study will be able to lead the practice and participation of obese children and decrease the degree of obesity.