• Proceedings of the Microbiological Society of Korea Conference
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• 2005.05a
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• pp.208.3-208
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• 2005

• Journal of Korean Clinical Nursing Research
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• v.25 no.1
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• pp.43-54
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• 2019

Purpose: Exposure to blood and body fluids represents a significant occupational risk for nurses. This study was done to identify the level of knowledge of and compliance with blood-borne pathogen prevention of hospital nurses according to clinical experience, and to identify factors affecting compliance with blood-borne pathogen prevention. Methods: A descriptive correlational study was conducted in which self-reported knowledge of and compliance with blood-borne pathogen prevention was assessed. The relationships between variables were examined. Registered nurses who were employed (n=345) were surveyed. Data were analyzed using, t-test, ANOVA, Pearson correlation, and multiple linear regression. Results: Nurses with more than 5 years experience had greater knowledge of blood-borne pathogen prevention than nurses with less than 5 years experience. However, there was no significant difference in compliance with blood-borne pathogen prevention between the two groups. No significant correlation was found between knowledge and compliance with blood-borne pathogen prevention according to experience standards. In nurses with less than 5 years experience, gender, age, reported exposure to a blood-borne pathogen, and compliance with principles of prevention had a significant impact on compliance with blood-borne pathogen prevention. For nurses with more than 5 years experience, reporting after exposure to blood-borne pathogen was a contributing factor to compliance with blood-borne pathogen prevention. Conclusion: The study results show that to improve the implementation of preventive measures against blood-borne pathogens different strategies are needed, depending on clinical experience of the nurses.

• Biomedical Science Letters
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• v.21 no.4
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• pp.165-171
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• 2015

Microbial pathogens are responsible for most of the rapidly-spreading deadly infectious diseases against humans. Thus, there is an urgent need for efficient and rapid detection methods for infectious microorganisms. The detection methods should not only be targeted and specific, but they have to be encompassing of potential changes of the pathogen as it evolves and mutates quickly during an epidemic or pandemic. The existing diagnostics such as the antibody-based ELISA immunoassay and PCR methods are too selective and narrowly focused; they are insufficient to capture newly evolved mutant strains of the pathogen. Here, we introduce a fresh perspective on some new technologies, including aptamers and next generation sequencing for pathogen detection. These technologies are not in their infancy; they are reasonably mature and ready, and they hold great promise for unparalleled applications in pathogen detection.

• Journal of Korean Medical classics
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• v.21 no.1
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• pp.295-302
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• 2008

Until the middle of the 20th century, exogenous febrile disease was the most common disease that threatened the human health. For a long time, oriental medicine doctors developed many ways to cure this disease by studying pathogenic factors. The phthogenic factors and treatments of exogenous febrile disease with time are as followings. "Naegyeong(內經)" : Cold pathogen. Diaphoretic therapy, purgation therapy. Hwata : Cold pathogen. Diaphoretic therapy, emetic therapy, purgation therapy. Jangjunggyeong(張仲景) : Cold pathogen. Eight principal therapeutic methods except diaphoretic therapy with pungent and cool properties. Yuhagan(劉河間) : Fire pathogen. Diaphoretic therapy with pungent and cool properties. Idongwon(李東垣) : Improper diet and overstrain. Reinforcing therapy. Ouga(吳又可) : Epidemic pathogenic factors. Diaphoretic therapy with pungent and cool properties, Heat-reducing therapy. purgation therapy Seopcheonsa(葉天士) : Warm pathogen. diaphoretic therapy, Heat-reducing therapy, expel Heat therapy, cooling the blood and eliminating stagnation of blood. Oguktong(吳鞠通) : Six pathogenic factors. Eight principal therapeutic methods including diaphoretic therapy with pungent and cool properties.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2000.10a
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• pp.21.1-21
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• 2000

• Proceedings of the Korean Society of Plant Pathology Conference
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• 1999.10a
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• pp.86.2-86
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• 1999

• Proceedings of the Microbiological Society of Korea Conference
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• 2005.05a
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• pp.196.2-196
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• 2005

• Journal of Microbiology and Biotechnology
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• v.25 no.10
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• pp.1614-1620
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• 2015

Plasmid-cured derivative strains of Bacillus anthracis are frequently used in laboratory studies. Plasmid incompatibility, which does not increase the risk of chromosomal mutation, is a useful method for plasmid curing. However, in bacteria containing multiple plasmids, it often requires the sequential introduction of multiple, specific incompatibility plasmids. This lengthy process renders the traditional plasmid incompatibility method inefficient and mutation-prone. In this study, we successfully cured plasmids pXO1 and pXO2 from B. anthracis A16 simultaneously using only one recombinant incompatible plasmid, pKORT, to obtain a plasmid-free strain, designated A16DD. This method may also be useful for the simultaneous, one-step curing of multiple plasmids from other bacteria, including Bacillus thuringiensis and Yersinia pestis.

• Journal of Applied Biological Chemistry
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• v.60 no.3
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• pp.265-269
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• 2017

Environment-friendly, commercially-available agricultural products were investigated for antimicrobial activity against Sclerotinia sclerotiorum, as a pathogen of sclerotium disease. Then ${\beta}$-thujaplicin from Chamaecyparis obtuse was investigated for antifungal activity against six kinds of pathogenic fungi. It showed a statistically significant (p <0.001) growth inhibition effect on Sclerotinia sclerotiorum as a pathogen of sclerotium disease, Rhizoctonia solani AG-4 as a pathogen of damping off, Phytophthora capsici as a pathogen of phytophthora blight, and Colletotrichum coccodes as a pathogen of anthracnose at a concentration of 50 ppm and on Stemphylium solani as a pathogen of spotting disease and Alternaria alternata as a pathogen of black mold at a concentration of 100 ppm. In conclusion, these results indicate that it may be possible to develop environment-friendly agricultural products using ${\beta}$-thujaplicin compounds.

• Nonlinear Functional Analysis and Applications
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• v.28 no.3
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• pp.659-670
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• 2023

In this paper, we study the distributed optimal control problem of a coupled system of the host-pathogen model. The system consists of the density of the susceptible host, the density of the infected host, and the density of pathogen particles. Our main goal is to minimize the infected density and also to decrease the cost of the drugs administered. First, we prove the existence and uniqueness of solutions for the proposed problem. Then, the existence of the optimal control is established and necessary optimality conditions are also derived.