• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.5
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• pp.115-121
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• 2007

Phase contrast imaging in atomic force microscopy showed a promise as an effective tool for better understanding of micromechanical properties of surfaces at nano scale. A qualitative estimation model for phase contrast images obtained with a tapping mode AFM was developed. This investigation demonstrated the high efficiency of combined analysis of topography and phase contrast images for characterizing nanosurfaces. Phase contrast images allowed estimation of relative stiffness(elastic modulus) of the sample surface. The phase contrast images revealed a significant inhomogeneity of the nano scale worn surfaces. Phase contrast images are also capable of revealing the formation of tribofilms.

• Journal of Biomedical Engineering Research
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• v.20 no.2
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• pp.165-172
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• 1999

An enhancement technique for phase dependent image contrast in MRI(Manetic Resonance Imaging) is proposed. Because the method can enhance inherent phase contrast it is suited for susceptibility imaging and flow imaging where intravoxel phase is a source of image contrast. In this paper, applying external phase in the voxel enhances phase contrast. The external phase is generated by a tailored RF pulse so that one can control the phase contrast and even produces phase only contrast. Signal intensity due to both inherent phase and external phase is analyzed and the proposed technique is applied to a susceptibility effect only imaging and a flow effect only imaging. To verify the proposed technique, computer simulations are performed and their results are given.

• Journal of the Optical Society of Korea
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• v.12 no.4
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• pp.319-325
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• 2008

We propose a phase contrast filter using photopolymer, for the phase contrast projection display. The photopolymer has high photosensitivity such that its optically induced refractive index change has a linear dependency on the illuminating light intensity. We implemented a phase contrast projection display using photopolymer as a phase contrast filter. By controlling the refractive index change of the photopolymer, we successfully convert an input phase image into a high contrast intensity image. We also investigated the effect of the photopolymer illumination condition on the quality of the displayed intensity image. As a projector, we achieved 82% phase to intensity conversion efficiency, which implies that the proposed method can potentially have much higher light efficiency than conventional projection display.

• Journal of the Optical Society of Korea
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• v.19 no.1
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• pp.22-28
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• 2015

We propose a new method for improving the phase contrast of a multiphase digital holographic microscope using a spatial light modulator (SLM). Using the SLM as the annulus, our method improves the light contrast of the object edge to achieve higher accuracy. We demonstrate a digital holographic microscopy technique that provides a 30% improvement in the phase contrast compared to conventional microscopy, which utilizes a mechanical annulus. The phase-contrast improvement allows the 3D reconstructed hologram to be determined more precisely.

• Journal of the Korean Society of Radiology
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• v.14 no.7
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• pp.937-946
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• 2020

The grating interferometer provides the differential phase contrast image of an phase object due to refraction of the wavefront by the object, and it needs to be converted to the phase contrast image. The line-integration process to obtain the phase contrast image from a differential phase contrast image accumulates noise and generate stripe artifacts. The stripe artifacts have noise and distortion increases to the integration direction in the line-integrated phase contrast image. In this study, we have configured and compared several machine learning methods to reduce the artifacts. The machine learning methods have been applied to simulated numerical phantoms as well as experimental data from the X-ray and neutron grating interferometer for comparison. As a result, the combination of the wavelet preprocessing and machine learning method (WCNN) has shown to be the most effective.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.40 no.4
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• pp.291-298
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• 2003

It is important to visualize a lesion accurately in diagnosis of disease. Many diseases result in a change of lesion. Magnetic resonance angiography can visualize the morphological characteristics of blood vessel. The magnetic resonance angiography (MRA) can be categorized to time-of-flight, phase contrast, and contrast enhanced MRA. In this paper, we introduce a principle, sequence, and feature of angiography For better image quality we describe data processing methods and show several applications to human bodies

• Journal of Veterinary Science
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• v.21 no.4
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• pp.55.1-55.11
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• 2020

Background: Computed tomography urography (CTU), based on the excretion of contrast medium after its injection, allows visualization of the renal parenchyma and the renal collecting system. Objectives: To determine the optimal contrast medium dose allocation ratio to apply in split-bolus CTU in dogs. Methods: This prospective, experimental, exploratory study used 8 beagles. In 3-phase CTU, unenhanced-, nephrographic-, and excretory-phase images were obtained with a single injection of 600 mg iodine/kg iohexol. In split-bolus CTU, two different contrast medium allocation ratios (30% and 70% for split CTU 1; 50% and 50% for split CTU 2) were used. Unenhanced phase image and a synchronous nephrographic-excretory phase image were acquired. Results: Although the attenuation of the renal parenchyma was significantly lower when using both split CTUs than the 3-phase CTU, based on qualitative evaluation, the visualization score of the renal parenchyma of split CTU 1 was as high as that of the 3-phase CTU, whereas the split CTU 2 score was significantly lower than those of the two others. Artifacts were not apparent, regardless of CTU protocol. The diameter and opacification of the ureter in both split CTUs were not significantly different from those using 3-phase CTU. Conclusions: Split-bolus CTU with a contrast medium allocation ratio of 30% and 70% is feasible for evaluating the urinary system and allows sufficient enhancement of the renal parenchyma and appropriate distention and opacification of the ureter, with similar image quality to 3-phase CTU in healthy dogs. Split-bolus CTU has the advantages of reducing radiation exposure and the number of CT images needed for interpretation.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2521-2526
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• 2015

Objective: The purpose of this study was to evaluate computed tomography (CT) virtual non-contrast (VNC) spectral imaging for gastric carcinoma. Materials and Methods: Fifty-two patients with histologically proven gastric carcinomas underwent gemstone spectral imaging (GSI) including non-contrast and contrast-enhanced hepatic arterial, portal venous, and equilibrium phase acquisitions prior to surgery. VNC arterial phase (VNCa), VNC venous phase (VNCv), and VNC equilibrium phase (VNCe) images were obtained by subtracting iodine from iodine/water images. Images were analyzed with respect to image quality, gastric carcinoma-intragastric water contrast-to-noise ratio (CNR), gastric carcinoma-perigastric fat CNR, serosal invasion, and enlarged lymph nodes around the lesions. Results: Carcinoma-water CNR values were significantly higher in VNCa, VNCv, and VNCe images than in normal CT images (2.72, 2.60, 2.61, respectively, vs 2.35, $p{\leq}0.008$). Carcinoma-perigastric fat CNR values were significantly lower in VNCa, VNCv, and VNCe images than in normal CT images (7.63, 7.49, 7.32, respectively, vs 8.48, p< 0.001). There were no significant differences of carcinoma-water CNR and carcinoma-perigastric fat CNR among VNCa, VNCv, and VNCe images. There was no difference in the determination of invasion or enlarged lymph nodes between normal CT and VNCa images. Conclusions: VNC arterial phase images may be a surrogate for conventional non-contrast CT images in gastric carcinoma evaluation.

• Current Optics and Photonics
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• v.7 no.5
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• pp.537-544
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• 2023

Differential phase contrast (DPC) microscopy, a central quantitative phase imaging (QPI) technique in cell biology, facilitates label-free, real-time monitoring of intrinsic optical phase variations in biological samples. The existing DPC imaging theory, while important for QPI, is grounded in paraxial diffraction theory. However, this theory lacks accuracy when applied to high numerical aperture (NA) systems that are vital for high-resolution cellular studies. To tackle this limitation, we have, for the first time, formulated a nonparaxial DPC imaging equation with a transmission cross-coefficient (TCC) for high NA DPC microscopy. Our theoretical framework incorporates the apodization of the high NA objective lens, nonparaxial light propagation, and the angular distribution of source intensity or detector sensitivity. Thus, our TCC model deviates significantly from traditional paraxial TCCs, influenced by both NA and the angular variation of illumination or detection. Our nonparaxial imaging theory could enhance phase retrieval accuracy in QPI based on high NA DPC imaging.

• Tribology and Lubricants
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• v.18 no.2
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• pp.138-143
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• 2002

Abstract - Tribofilms formed on won surface protect the DLC coating surface and decrease the fiction coefficient. However it is very difficult to evaluate their micromechanical properties due to their small thickness, inhomogeneity and discontinuity. The phase contrast images in tapping mode atomic farce microscopy allow an estimation of inhomogeneity in micromechanical properties of the sample surface. The purpose of this investigation is to demonstrate how the phase contrast images contribute to the characterization of thin tribofilms.