• 전기전자학회논문지
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• 제11권3호
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• pp.108-116
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• 2007

This paper proposed an analyzable parameter and its analytic method to provide more accurate information than currently employed 4 channels system which uses pulse wave velocity (PWV) information of the volume pulse wave measured from 4 arterial channels for the characterization of arterial vessel. In order to verify the volume pulse waves on 4 sites were simultaneously acquired subjects aged from 12 to 81 years old. and the proposed parameters were extracted from time (UT) was then compared with blood pressure. Then, the regression analyses were done relationships among the proposed parameter and others, such as aging, pulse transit time pressure (BP). The followings are the results of linear regression analysis of the proposed parameter for total 50 normal subjects. We selected any two subjects (58 years and 27 years) and measured PPG (photoplethysmogram) and BP of before and after exercise. The coefficient of correlations between BP and UT observed was -0.928 for 50 years subject, and -0.922 for 20 years subject. For total 50 normal subjects, in case of correlation between the pulse transit time and BP, the result showed -0.170 on left side and -0.233 on right side, and the coefficient value of correlation between the pulse transit time and UT was -0.607 on left side and -0.510 on right side. UI is strongly correlated with the pulse transit time than BP. Hence, we believe that the proposed parameter is related with the index of arterial stiffness.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2012년도 춘계학술대회 논문집
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• pp.749-750
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• 2012

• 대한의용생체공학회:의공학회지
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• 제27권3호
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• pp.89-93
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• 2006

A simple algorithm that can be used to estimate a healthy person's blood pressure using pulse transit time is proposed in this paper. Fifty healthy students participated in the experiment that was conducted in line with the study. The subjects were asked to exercise on several exercise levels using a bicycle ergometer. Their blood pressures during the succeeding rest period were measured. A simple method was proposed to illustrate the relationship between blood pressure and pulse transit time. The systolic blood pressures as well as the heights and weights of the subjects were regarded as the proper parameters, and a second-order regression curve was produced to estimate the subjects' blood pressures. The mean error of estimation was less than 10 mmHg, which was the mean error of manual measurement. Although our estimation model is so simple, it can be used to estimate continuous blood pressure measurement for bicycle ergometer exercise. The electrocardiograms, photoplethysmograms, and blood pressures, however, could not be measured simultaneously As such, their estimation may be slightly different from the results taken from simultaneous measurements.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.834-837
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• 2005

In this paper, we describe the method of non-invasive blood pressure measurement using pulse wave transit time(PWTT). PWTT is a new parameter involved with a vascular that can indicate the change of BP. PWTT is measured by continuous monitoring of ECG and pulse wave. No additional sensors or modules are required. In many cases, the change of PWTT correlates with the change of BP. We measure pulse wave using the photo plethysmograph(PPG) sensor in an earlobe and we measure ECG using the ECG monitoring device our made in the chest. The measurement device for detecting pulse wave consists of infrared LED for transmitted light illumination, pin photodiode as light detector, amplifier and filter. We composed 0.5Hz high pass, 60Hz notch and 10Hz low pass filter. ECG measurement device consists of multiplexer, amplifier, filter, micro-controller and RF module. After amplification and filtering, ECG signal and pulse wave is fed through micro-controller. We performed the initial work towards the development of ambulatory BP monitoring system using PWTT. An earlobe is suitable place to measure PPG signal without the restraint in daily work. From the results, we can know that the dependence of PWTT on BP is almost linear and it is possible to monitoring an individual BP continuously after the individual calibration.

• 전기학회논문지
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• 제62권7호
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• pp.1020-1026
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• 2013

Multirate filtering process on the biological signals like Electrocardiogram (ECG) and Photoplethysmogram (PPG) can be defined as the digital signal processing algorithm in which the sampling rate varies to omit or interpolate the intermediate values between the sampled data. With this aim, we suggest a new multirate filtering algorithm by deleting the extraneous data to eliminate the unwanted degradations such as granular noise due to the usage of high sampling frequency and simultaneously to detect the fiducial features of ECG and PPG with reducing the complexity of resolving fiducial points such as R-peak, Pulse peak and Pulse Transit Time (PTT). After the experimental simulations performed, we can conclude the fact that we can detect the fiducial features of ECG and PPG signal in terms of R-peak, Pulse peak and PTT without the loss of accuracy even if we do not maintain the original sampling frequency.

• 전기학회논문지
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• 제56권8호
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• pp.1514-1520
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• 2007

Currently, the signal of the human body is measured with various methods, and a noninvasive investigation of various methods is useful diagnosis method. PTT(Pulse Transit Time) which is noninvasive investigation make use of to estimate the physiological phenomena. PTT has a latent information of cardiovascular system. So we have the experiments for analysis of the relations between PTT and physiological parameters. We examine to correlate to the physiological parameters, an age and degree of paralysis on the ultrasound therapy. The 40 patients who has a such paralysis join our experiment, and we obtain the PTT data that normal condition and states after ultrasound therapy. We study that PTT after the ultrasound therapy for patients who have a paralysis was related to an age and degree of paralysis.

• 한국전기전자재료학회논문지
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• 제21권8호
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• pp.770-775
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• 2008

Autonomic nervous system of the anesthetized patients can be influenced by the many kinds of stimulations such as intubation, surgical incision and so on. The changes of the heart rates and blood pressures are surrogates of responses of the autonomic system to the external stimulations. Recently, the power spectral analysis of the heart rate variability (HRV) made it easy to know the fractions and changes of sympathetic and parasympathetic autonomic systems. In this study, the changes of pulse transit time, one of the response of vessels to stimulations, was investigated in relation to the HRV. Ten patients were examined and average age is 22.5 $\pm$ 11.04, average weight is 63 $\pm$ 14.4 kg. The patients were anesthetized only by sevoflurane inhalation. Pulse transit time is determined by calculating the difference of the time between the R peak of ECG and the characteristic point of the plethysmography. Power spectral density (PSD) of the HRV was achieved in the frequency of 0.04-0.15 (LF) and 0.15-0.4 (HF). Compared to preanesthetic period the values of LF and LF/HF ratio of HRV were decreased (p<0.05). HF and PTT was increased in anesthetic state with sevoflurane. Otherwise, after intubation, the HF was decreased and LF, LF/HF ratio and PTT were increased. PSD of the HRV is well-known for the index of the autonomic nervous activity. Not only HRV but PTT analysis also is a useful index reflecting the autonomic responses to various stimulations. And this analysis is useful in bed side monitoring because the calculating method is simple and it takes shorter processing time compared to the HRV analysis.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2007년도 추계종합학술대회
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• pp.265-267
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• 2007

고혈압을 진단하고 치료함에 있어 정기적인 혈압의 측정 및 관리는 매우 중요하다. 본 논문에서는 요골 동맥혈에서 혈압 측정을 하기 위한 심전도 측정기와 광용적맥파 측정기를 설계하여 구성하였으며, 이를 이용한 맥파 전달 시간 측정을 LA(Left Arm), RA(Right Arm)에서 심전도와 요골동맥에서 광 용적맥파 신호를 측정하였다.

• 대한의용생체공학회:의공학회지
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• 제23권6호
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• pp.485-489
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• 2002

본 연구는 동맥의 압력에 따라 변하는 맥파전달시간(pulse transit time, PTT)을 이용하여 호흡노력을 검출하기 위하여 호흡에 따른 PTT 변화를 관찰하였다. PTT는 심전도의 R파 피크로부터 말초에서 나타나는 광전용적맥(photoplethysmograph, PPG)의 최대기울기점까지 시간이다. 생체 신호를 아날로그-디지탈 변환하여 PC에서 매번 심장주기마다 PTT를 측정하였으며 이산적인 결과를 스플라인 보간법을 사용하여 그래프로 제시하였다. 소프트웨어는 $C^{++}$을 사용하여 windows 환경에서 운용하였다. 안정상태 호흡 시에는 호흡의 주기와 일치하는 주기적인 PTT의 변화가 있었다. 호흡 심도를 증가시킴에 따라 PTT의 진폭이 증가하였으며, 기도저항을 증가시킨 경우에도 PTT의 진폭이 증가하는 양상을 보였다. 이러한 결과는 PTT가 호흡노력에 따라 반응하는 것을 시사한다. 아울러 PTT를 이용한 호흡노력 모니터링은 비침습적 방법으로써 호흡장애를 감시하는데 유용하게 사용될 수 있음을 시사한다.

• 센서학회지
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• 제17권2호
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• pp.87-94
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• 2008

Blood pressure (BP), one of the most important vital signs, is used to identify an emergency state and reflects the blood flow characteristics of the cardiovascular system. The conventional noninvasive method of measuring BP is inconvenient because patients must wear a cuff on their arm and the measurement process takes time. This paper proposes an algorithm for estimating the BP using the pulse transit time (PTT) of the photoplethysmography (PPG) and pressure pulse from finger at the same time as a more convenient way to measure the BP. After recording the electrocardiogram (ECG), measuring the pressure pulse, and performing PPG, we calculated the PTT from the acquired signals. Then, we used a multiple regression analysis to measure the systolic and diastolic BP indirectly. Comparing the BP measured indirectly using the proposed algorithm and the real BP measured with a sphygmomanometer, the systolic pressure had a mean error of ${\pm}3.240$ mmHg and a standard deviation of 2.530 mmHg, while the diastolic pressure had a satisfactory result, i.e., a mean error of ${\pm}1.807$ mmHg and a standard deviation of 1.396 mmHg. These results are more superior than existing method estimating blood pressure using the one PTT and satisfy the ANSI/AAMI regulations for certifying a sphygmomanometer i.e., the measurement error should be within a mean error of ${\pm}5$ mmHg and a standard deviation of 8 mmHg. These results suggest the possibility of applying our method to a portable, long-term BP monitoring system.