• Natural Product Sciences
• /
• v.5 no.4
• /
• pp.186-189
• /
• 1999

To analyze scientifically the fundamental formulation theory and drug interaction on the purgative action of Chungpesagan-tang, which is one of the traditional Korean medical prescriptions that has been most frequently used for stroke, water extracts of herbal medicines with Rhei Rhizoma were administered into mice and the purgative action was measured. Water extracts of Raphani Semen or Cimicifugae Rhizoma with Rhei Rhizoma had more potent purgative activity than Rhei Rhizoma alone, although Raphani Semen alone displayed no purgative action. However, Platycodi Radix and Puerariae Radix inhibited the purgative action of Rhei Rhizoma. When Rhei Rhizoma with Raphani Semen or Cimicifugae Radix was extracted with water, sennoside A content in the water extract was increased. However, Puerariae Radix and Platycodi Radix decreased the content of sennoside A in the extracted water. The transforming rate of sennoside A of Rhei Rhizoma was inhibited by Puerariae Radix and Platycodi Radix. The transforming rate of sennoside A of Chungpesagan-tang to rheinan-throne by human intestinal microflora and its purgative activity were similar to those of Rhei Rhizoma. Finally we thought that the purgative action of Chungpesagan-tang could be controlled by the addition and subtraction of Chungpesagan-tang-composing herbal medicines.

• Natural Product Sciences
• /
• v.6 no.4
• /
• pp.161-164
• /
• 2000

Herbal medicinal interaction on the purgative action of Chungpesagan-tang, which is one of the traditional Korean medical prescriptions that has been most frequently used for stroke was investigated. Chungpesagan-tang had more potent purgative activity than Rhei Rhizoma alone. When each Chungpesagan-tang composing herbal medicine with Rhei Rhizoma was extracted with water, water extract of Raphani Semen with Rhei Rhizoma had the most potent purgative activity. However, Raphani Semen had not purgative activity. When Rhei Rhizoma with Raphani Semen was extracted, sennoside A content in the water extract was increased. The transformation of sennoside A of Rhei Rhizoma to rheinanthrone by human intestinal microflora was weakly induced by Raphani Semen. These results suggest that the purgative action of Chungpesagan-tang could be controlled by the addition and subtraction of Chungpesagan-tang-composing herbal medicines.

• The Journal of Korean Medicine
• /
• v.20 no.3 s.39
• /
• pp.87-93
• /
• 1999

Objectives: This study was conducted to analyze scientifically the purgative action of Chungpesagan-tang, which was widely used for stroke In Oriental Medicine. Methods: The contents of sennoside A on the water-extraction of Rhei Rhizoma, the transforming activity of sennoside A to rheinanthrone by human intestinal bacteria, and the anti-costive activity of Chungpesagan-tang, Rhei Rhizoma and Yuldahanso-tang on mice were investigated. Results: Rhei Rhizoma (Rheum palmatum, from China) had dose-dependent potent purgative action. Chungpesagan-tang containing this Rhei Rhizoma had more potent purgative action than Rhei Rhizoma only. However, Korean cultivated Rhei Rhizoma (Rheum undulatum) and Chungpesagan-tang containing this Korean cultivated Rhei Rhizoma had no purgative action. Conclusions: These results suggest that Chungpesagan-tang polyprescription should be considered to enhance the purgative action of Rhei Rhizoma.

• Journal of Oriental Neuropsychiatry
• /
• v.22 no.4
• /
• pp.125-134
• /
• 2011

Objectives : This study was designed to report the effect of Jawon(Ziuan)'s purgative action for insomnia. Methods : A 60 year-old male patient has been suffered from insomnia for 2 years and has been on taking sleeping tablets during about a year and a half. We administered Sihogayonggolmoryeo-tang because we thougt that the disease was So-Yang-Bing Li Jeung. And Jawon was added for quick improvement. Results : 1. The score of PSQI(Pittsburgh Sleep Quality Index) decreased from 18 to 16 after the patient tooks Sihogayonggolmoryeo-tang. 2. After 23 days, the patient tooks Sihogayonggolmoryeo-tang with Jawon at the same time. With the purgative action with Jawon appearing, the score of PSQI decreased from 16 to 4 extremely and accompanying symptoms were also improved. Conclusions : In this case, for the patient taking Sihogayonggolmoryeo-tang with Jawon at the same time is far more effective than only doing Sihogayonggolmoryeo-tang. The result was more improved with appearing the effect of purgative action.

• Korean Journal of Pharmacognosy
• /
• v.34 no.1 s.132
• /
• pp.45-54
• /
• 2003

We have conducted to characterize the physico-chemical change and pharmacological transformation of traditional herbal medicines by means of processing. Processed Gardeniae Fructus was prepared by heating of fruit of Gardenia jasminoides(GF) for $30{\sim}50\;minute$ in the roster designed for herb processing. The contents of drying loss, water extract, diluted ethanol extract, ether extract and geniposide in non-processed GF and processed GF were examined. The contents of drying loss, water extract and geniposide in processed GF showed a decrease as compared with those of non-processed GF, however the contents of dilute ethanol and ether extract showed a increase as compared with those of non-processed GF. The rate of decrease/increase of those index were in proportion to heating time. And, biological activities of methanol extract of non-processed GF and processed GF were investigated. DPPH scavenging effects and inhibitory effect of xanthine oxidate and hemolysis of processed GF exhibited more effective than those of non-processed GF in vitro. Accelerating effect of large intestinal transport and purgative action of non- processed GF were discriminated by processing of GF. Methanol extracts of non-pro- cessed GF and processed GF showed the protective effects against the hepatotoxicity induced by ${\alpha}-naphthylisothiocyanate$ in rats. These results suggested that the transformation of biological activities of GF by means of processing may be due to the physico-chemical change of the constituents in GF by heating.

• CELLMED
• /
• v.12 no.1
• /
• pp.2.1-2.9
• /
• 2022

The study has been carried out for the comparative analysis of relevant literature in order to highlight the present topic "Clinical study on effect on Virechana karma (therapeutic purgation)". Total no. of 40 cases has been selected from OPD and IPD of Panchakarma department, through proper history taking and clinical examination prior to VirechanaKarma. Only VirechanaKarmaYogya subjects were selected for the VirechanaKarma. Analysis of VirechanKarma on the basis of Vegiki (purgative bouts), Maniki (quantity), Langiki (clinical features) and Aantiki (end product) features were done in this study. In this study a highly significant relief was found in patients i.e. p<0.001 due to Virechana mainly vitiated PittaDosha (the heat energy in the body) and secondary Kaphadosha (mucus) and VataDosha (subtle energy associated with movement) are being expelled out which might have accounted for better relief in VirechanYogya (indicated) individuals (Pitta Pradhan Vyadhi (vitiated pitta), RaktajRoga (hemopoietic diseases), ShodhanYogyaAvastha (detoxification), etc.) in the above group of patients. VirechanaDravyas have properties like Tikshna (hyperfunction), Sukshma(subtle), Ushna (heat), etc. are described in Ayurvedic classics which play a vital role in the mode of action of VirechanaKarma has also been explained under probable mode of action.

• The Journal of Internal Korean Medicine
• /
• v.21 no.4
• /
• pp.667-670
• /
• 2000

The patient who has DM, Hypertension, Arrithemia, Arteral fibrillation, Heart failure attacted cerebral infartion and he was took treatment by chungpesagan-tang and mannitol at the same time for 4 days and only chungpesagan-tang for 3 days. General condition improved but at seventh day cold sweating and hypothermia appeared. So we take chest x-ray. The result is fleural effusion. Chungpesagan-tang is the method of Purgative action so heart function is injured in circulation. In the results we consider that the medication of chungpesagan-tang and mannitol at the same time is bad influence on heart and induce ftueral effusion.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.23 no.4
• /
• pp.818-824
• /
• 2009

This study aimed to evaluate the effect of purgation therapy with Natrii sulfas, a therapy for stroke patients with constipation in the oriental medicine, on the ischemic brain damage of the rats. The ischemic brain damage was induced by the middle cerebral artery occlusion (MCAO), Natrii sulafas was administered once after the MCAO. After 48 hours, expressions of Bax, Bcl-2, c-Fos, and HSP72 on the brain tissues were observed by immunohistochemistrical methods or technique. Purgation therapy with Natrii sulfas attenuated the excess of Bax expression caused by the ischemic brain damage. It was significant statistically in the penumbra of cerebral cortex, but not in the caudate putamen, of the MCAO rats. Purgation therapy with Natrii sulfas did not attenuate the excess of Bcl-2 expression caused by the ischemic brain damage. Purgation therapy with Natrii sulfas did not attenuate the excess of c-Fos expression caused by the ischemic brain damage. Purgation therapy with Natrii sulfas attenuated the excess of HSP72 expression caused by the ischemic brain damage. It was significant statistically in the penumbra of cerebral cortex, but not in the caudate putamen, of the MCAO rats. These results suggest that purgation therapy with Natrii sulfas has a neuroprotective effect on the ischemic brain damage and an anti-apoptotic effect.

• The Journal of Korean Medicine
• /
• v.30 no.5
• /
• pp.77-87
• /
• 2009

Objectives: This study aimed to evaluate the effect of purgation therapy with Natrii sulfas, an oriental medical therapy for stroke patients with constipation, on physiological indexes and the brain edema of rats. Methods: Brain edema was induced by the middle cerebral artery occlusion (MCAO); Natrii sulfas was administered once after the MCAO. At 3, 6, 15, 24, 48 hours after reperfusion, physiological indexes such as fecal weight, urine volume and water content in stool were assessed, and at 48 hours after reperfusion the edema index was measured. Results: 1. Purgation therapy with Natrii sulfas significantly improved the reduction of fecal weight caused by ischemic insult (P<0.05). 2. Purgation therapy with Natrii sulfas significantly improved the reduction of urine volume caused by ischemic insult (P<0.05). 3. Purgation therapy with Natrii sulfas significantly improved the reduction of water content in stool caused by ischemic insult (P<0.05). 4. Purgation therapy with Natrii sulfas did not improve the neurological symptom caused by ischemic insult. 5. Purgation therapy with Natrii sulfas did not attenuate the total infarct volume caused by ischemic insult. 6. Purgation therapy with Natrii sulfas attenuated the brain edema caused by ischemic insult (P<0.05). Conclusions: These results suggest that purgation therapy with Natrii sulfas improves some important symptoms and has a protective effect on the brain edema caused by ischemic insult.

• Journal of Sasang Constitutional Medicine
• /
• v.25 no.2
• /
• pp.108-114
• /
• 2013

Objectives This study was aimed to review a standardized method of retention enema by extracting elements associated with methods of retention enema from papers involved. Methods 1) Data sources : Retrieval was made, using 'Enema' or 'Retention Enema' as search words in MEDLINE, The Cochrane Library, KISS, RISS, and NDSL DB. 2) Study selection : Two authors excluded irrelevant papers and chose qualified abstracts in the rest of the papers. The chosen studies were reviewed fully by the authors so that they could screen the significant papers based on the exclusion criteria. 3) Data extraction : Data on the total number of subjects, the target disease, the type, quality, length, diameter of catheter, the insertion length of catheter, the sample, the sample volume, the process of retention enema and the number of performing retention enema were extracted from the selected studies. Results & Conclusions The retention enema can be applied to gastrointestinal diseases, genitourinary diseases, metabolic diseases such as hypertension and diabetes, headaches and neurological disorders. The standardized treatment method is as following: 1) inserting a rental tube of 18-28 Fr that measures 20 to 30 cm into the patient's anus, 2) injecting herbal medicines which have purgative action or benefit on stomach and intestinal tract at the rate of 4 ml/min, and 3) holding them for 10 to 15 minutes.