• Title/Summary/Keyword: purinylidenes

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Synthesis and Structure of Purine Derivatives as Antitumor Effects

  • Moharram, H.H.;El-Bayouki, Khairy A.M.;Haggag, B.;Basyouni, W.M.;Osman, A.M.
    • Archives of Pharmacal Research
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    • v.12 no.2
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    • pp.138-142
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    • 1989

  • The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.

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