• Applied Chemistry for Engineering
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• v.17 no.3
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• pp.286-290
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• 2006

New quaternary ammonium chlorides, [alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadizol-2-ylmethyl]quaternary ammonium chlorides (ADOQACs): 6] were obtained with high yields by the reaction of compound 5 with N,N-dimethylalkyl amines in isopropyl alcohol. The structures and physical properties of the synthesized compounds were investigated and those surface-active properties were measured. The surface tension ($\gamma_{cmc}$) and the minimal inhibitory concentration (MIC) of compound 6 were found to be influenced by the number of alkyl chain carbon. Especially, compounds 6c and 6d exhibited high anti-bacterial activities and good surface-active properties.

• Journal of Fashion Business
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• v.7 no.2
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• pp.69-81
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• 2003

Among the various properties of textile fabrics, the moisture-related properties are important for the textile processes or the apparel comfort characteristics. Alkaline hydrolysis results in pitting on the surface of fibers and increases the amount of hydroxyl and carboxyl end groups of the PET molecules on the fiber surface. The purpose of this study is to investigate the moisture-related properties of PET fabrics treated with quaternary ammonium compound/alkaline solution. The wetting and wicking properties of the PET fabrics were measured using the following experiments: contact angle, surface free energy, work of adhesion, vertical wicking height, moisture regain, and frictional static voltage. It was concluded that by the alkaline hydrolysis process, surface hydrophilicity and reactivity were considerably improved especially at lower levels of weight loss% and that the pitting of the fiber surface resulted in at higher levels of weight loss% was disadvantageous in moisture-related properties of PET.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.14 no.1
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• pp.16-37
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• 1988

A new quaternary ammonium compound, hydrolyzed ginseng-sapoin quaternary (HGSQ), from hydrolyzed Korean ginseng-saponin and 2, 3-epoxypropyltrimethyl ammonium chloride has been developed as a conditioning agent for hair care products. This structure has the hydrophilic group from the introduced cationic and the hydrophobic group from the aglycone of ginseng saponin. Its properties: surface tension, conductivity, critical micelle concentration, eye irritation, sorption onto hair, force reduction (%) for 20% extension and moisture retention effect comparing with the commercial standards. Also half-head tests of HGSQ-containing shampoo were carried out to compare the conditioning effects in shampoos.

• Macromolecular Research
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• v.17 no.3
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• pp.144-148
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• 2009

Poly(1-oxo-2-phenyltrimethylene) was synthesized by palladium-catalyzed copolymerization of styrene and carbon monoxide in quaternary ammonium ionic liquids. The $[Pd(bipy)_2][PF_6]_2$ compound had relatively more catalytic activity than $[Pd(bipy)_2][BF_4]_2$ in ionic liquids. The catalytic activity of palladium (II) composite catalyst was superior to the catalyst formed in situ from palladium acetate, 2,2-bipyridyl, and $X^-$ ($X^-=PF_6^-$, $BF_4^-$) in ionic liquids. The effects of the volume of ionic liquids, reaction time and benzoquinone content on the copolymerization were also described.

• Korean Journal of Environmental Agriculture
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• v.22 no.3
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• pp.177-184
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• 2003

Although clay can sorb significant amounts of inorganic contaminants from soils and wastewater, the hydration of exchangeable cations in clay minerals makes it hydrophilic at the clay mineral surfaces and interlayers. Thus, natural clays are often ineffective in complexing and stabilizing toxic organic contaminants in soils and groundwater environment. But, substituting these hydrated cations with cationic surfactant such as QAC(Quaternary ammonium Compound) can change the natural clay from hydrophilic to hydropobic. Furthermore functionalized organoclay can act as a powerful dual function sorbent for both toxic metals and organic compounds. It also can be used as landfill clay liners, slurry walls, nano-composite materials, petroleum tank farms, waste treatment, and filter systems. To use this modified clay minerals effectively, it is required to understand the fundamental chemistry of organoclay, synthetic procedures, its engineering application, bioavailability of sorbed ion-clay complex, and potential risk of organoclay. In this review, we investigate the use, application and historical background of the organoclay in remediation technology. The state-of-the-art of organoclay research is also discussed. Finally, we suggest some future implications of organoclay in environmental research.

• Journal of Ginseng Research
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• v.13 no.2
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• pp.189-197
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• 1989

A new quaternary ammonium compound, hydrolyzed ginseng-saponin quaternary (HGSQ), from Korean ginseng saponin and 2,3-epoxypropyltrimethylammonium chloride has been developed as a conditioning agent in cosmetics. This structure has a hydrophobic group from the aglycone of ginseng saponin which is biologically active and considered to be the most important component of the Korean ginseng. Its properties : surface tension, critical micelle concentration (CMC), eye irritation, sorption onto hair, force reduction(%) and moisture retention effect were studied. Its cationic character allows the molecule to be more substantive than ginseng saponin. HGSQ had good physical properties and was safe. enough as a cosmetic raw material. Also half-head tests of HGSQ-containing shampoo were carried out to compare the conditioning effects in shampoos. HGSQ was an excellent conditioning agent in shampoo..

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.331-337
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• 1994

In order to develop a $^{18}F$-labelled myocardial perfusion agent(flow tracer) for PET, $^{18}F$-labelled organic ammonium cations were synthesized and evaluated in relation to their biodistribution. Five quaternary organic ammonium compounds were labelled with $^{18}F$ in a side chain with moderate to good yields by direct introduction of $^{18}F$-fluoride. Radiochemical yields have been achieved in 30-40min by the precursors (tosylates) in dimethylsulfoxide 15-60% (decay corrected). The reaction was found to be autocatalyzed. A remote controlled procedure was developed in these synthesis. $^{18}F$-Labelling and HPLC-purification of com-pounds needed about 60 min(Yield; 7-20%). Up to now the two compounds N-4-[$^{18}F$]fluorobutyl-pyridinium cation(1) and N, N dibenzyl-4(2-[$^{18}F$]fluoroethyl)piperidinium cation(2) were investigated in relation to their biodistribution in mice. Compound 1 showed at 1 min post injection the high uptake of 19.22% ID/g organ in the myocardium but a following fast decline to 1.12% ID/g organ after 40min. Uptake of compound 2 was after 1min in the heart 5.90% ID/g organ but after 40min at the relative high value of 4.33% ID/g organ. Heart:blood ratio for compound(1) at 1 min was 8.3, at 40 min 2.6 for compound II 2.0(1min) and 15.0(40 min). As data of compound 2 showed greater heart uptake, slower myocardial release, and higher heart: blood ratios, compound 2 is a good candidate for further evaluation.

• Archives of Pharmacal Research
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• v.29 no.4
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• pp.318-322
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• 2006

Many quaternary ammonium salts are incompletely absorbed after their oral administration and may also be actively secreted into the intestine. However, the underlying mechanism(s) that control the transport of these cations across the intestinal epithelium is not well understood. In this study, the mechanism of absorption of quaternary ammonium salts was investigated using Caco-2 cell monolayers, a human colon carcinoma cell line. Tributylmethylammonium (TBuMA) was used as a model quaternary ammonium salts. When TBuMA was administrated at a dose of 13.3 imole/kg via iv and oral routes, the AUC values were $783.7{\pm}43.6\;and\;249.1{\pm}28.0{\mu}mole\;min/L$ for iv and oral administration, indicating a lower oral bioavailability of TBuMA $(35.6\%)$. The apparent permeability across Caco-2 monolayers from the basal to the apical side was 1.3 times (p<0.05) greater than that from the apical to the basal side, indicating a net secretion of TBuMA in the intestine. This secretion appeared to be responsible for the low oral bioavailability of the compound, probably mediated by p-gp (p-glycoprotein) located in the apical membrane. In addition, the uptake of TBuMA by the apical membrane showed a $Na^+$ dependency. Thus, TBuMA appears to absorbed via a $Na^+$ dependent carrier and is then secreted via p-gp related carriers.

• Journal of Dental Rehabilitation and Applied Science
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• v.36 no.1
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• pp.55-60
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• 2020

The aim of this study was to investigate the change of microbial contamination levels in the different areas and at the different time points after application of a quaternary ammonium compound (QAC) that has mechanical antimicrobial effect. The microbial contamination levels were measured in three different areas; unit chair handle, spit sink area and hand piece holder at different time points using adenosine triphosphate (ATP) monitoring system and ATP surface test kit. Hand piece holder showed the highest level of microbial contamination. In most of the clinics, QAC significantly reduced the levels of microbial contamination, and maintained antimicrobial activity for 4 to 6 months. QAC may be used effectively in dental clinics due to the duration of antimicrobial effect and the minimal exposure of chemicals and further studies are needed with large sample size.

• Journal of Veterinary Science
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• v.22 no.1
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• pp.11.1-11.7
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• 2021

Background: The spore-forming bacterium Bacillus anthracis causes anthrax, an often-fatal infection in animals. Therefore, a rapid and reliable strategy to decontaminate areas, humans, and livestock from B. anthracis is very critical. Objectives: The aim of this study was performed to evaluate the efficacy of sodium hypochlorite, calcium hypochlorite, and quaternary ammonium compound (QAC) sanitizers, which are commonly used in the food industry, to inhibit spores and vegetative cells of B. anthracis surrogate. Methods: We evaluated the efficacy of sodium hypochlorite, calcium hypochlorite, and a QAC in inhibiting vegetative cells and spores of a B. anthracis surrogate. We treated a 0.1-mL vegetative cell culture or spore solution with 10 mL sanitizer. The samples were serially diluted and cultured. Results: We found that 50 ppm sodium hypochlorite (pH 7), 1 ppm calcium hypochlorite, and 1 ppm QAC completely eliminated the cells in vegetative state. Exposure to 3,000 ppm sodium hypochlorite (pH 7) and 300 ppm calcium hypochlorite significantly eliminated the bacterial spores; however, 50,000 ppm QAC could not eliminate all spores. Conclusions: Calcium hypochlorite and QAC showed better performance than sodium hypochlorite in completely eliminating vegetative cells of B. anthracis surrogate. QAC was ineffective against spores of the B. anthracis surrogate. Among the three commercial disinfectants tested, calcium hypochlorite most effectively eliminated both B. anthracis vegetative cells and spores.