• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.974-979
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• 2008

A design process for the structure-borne noise in a passenger vehicle is presented. The proposed process is improved from the previous one. The major difference between the current and last ones is that most of the countermeasures should be developed before fixing a tool for structural parts. This is requested for QCDP(Quality, Cost, Delivery and Productivity) by the design engineers. The proposed one consists of 4 steps: Problem definition, Cause analysis, Development of counter-measure and Validation. Based on the general rule: divide and conquer, the complex problem can be simplified into a few critical sub-systems through the first step: Problem definition. Secondly, the critical causes can be identified for the critical sub-systems through the second step: Cause analysis. Thirdly, effective countermeasures are investigated and produced through the third step: Countermeasure development. The proposed countermeasures are finally validated in the forth step: Validation.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6619-6623
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• 2013

Background:The aim of the research was to explore a cost effective, fast, easy to perform, and sensitive method for epidermal growth factor receptor (EGFR) mutation testing. Methods: High resolution melting analysis (HRM) was introduced to evaluate the efficacy of the analysis for dectecting EGFR mutations in exons 18 to 21 using formalin-fixed paraffin-embedded (FFPE) tissues and plasma free DNA from 120 patients. Results: The total EGFR mutation rate was 37.5% (45/120) detected by direct sequencing. There were 48 mutations in 120 FFPE tissues assessed by HRM. For plasma free DNA, the EGFR mutation rate was 25.8% (31/120). The sensitivity of HRM assays in FFPE samples was 100% by HRM. There was a low false-positive mutation rate but a high false-negative rate in plasma free DNA detected by HRM. Conclusions: Our results show that HRM analysis has the advantage of small tumor sample need. HRM applied with plasma free DNA showed a high false-negative rate but a low false-positive rate. Further research into appropriate methods and analysis needs to be performed before HRM for plasma free DNA could be accepted as an option in diagnostic or screening settings.

• Journal of the Society of Naval Architects of Korea
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• v.51 no.3
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• pp.212-219
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• 2014

As subsea production has been revived up, the demand of subsea equipment has also been increased. Among the equipment, subsea tree plays a major role in safety. The tubing hanger is one of the most important components in subsea tree. In this study structural reliability analysis on dual bore tubing hanger of subsea tree is performed. The target reliability which is introduced in ISO regulation is used for judging whether tubing hanger is safe or not. The considered loads are working pressure, working temperature and suspended tubing weight. Thermal-stress analysis on tubing hanger is performed and kriging model is created based on the results of FEM analysis. According to von Mises criterion, limit state equation can be estimated. Reliability analysis is performed by using level 2 method and the result is verified by that of Monte Carlo Simulation. For finding most probable failure point, enhanced HL-RF method is adopted. Because the reliability of model doesn't reach target reliability, an improvement measure should be considered. Thus, it is suggested to change the material of tubing hanger main body to AISI 4140.

• Journal of Navigation and Port Research
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• v.42 no.5
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• pp.331-340
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• 2018

Shipping containers promote rapid development of the transport industry, and generate economic and social value. However, problems often occur due to imbalance in dynamics between exports and imports, container relocation, traffic congestion, and general shipping network designs. So, efficient and cost-effective cargo management has become crucial for the Jeju Island - Mokpo container route (JMCR) in South Korea. Dozens of recent studies reveal that collapsible or foldable containers, may become an innovative solution to problematic issues within the shipping industry. The major purpose of this study is to discuss conditions required for successful commercial application of foldable containers, based on a cost-benefit analysis precisely for the JMCR. Findings reveal usage of foldable containers can be cost-effective, if containers make a "FULL<->EMPTY" route. To the contrary, a "FULL<->FULL" route can drastically increase expenditure. However, economic analysis of actual figures for 2010-2015 indicate that benefits for Mokpo - Jeju direction are significant to cover losses on the Jeju - Mokpo line. Seasonal patterns and mixing percentages of foldable and standard containers on the route, may also produce cost-effective solutions. Sensitivity analysis reveals that benefits from using foldable containers, depend mostly on empty container shares in addition to various extra costs.

• Journal of Environmental Impact Assessment
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• v.9 no.3
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• pp.185-202
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• 2000

Uncertainty and variability in Life Cycle Assessment(LCA) have been significant key issues in LCA methodology with techniques in other research area such as social and political science. Variability is understood as stemming from inherent variations in the real world, while uncertainty comes from inaccurate measurements, lack of data, model assumptions, etc. Related articles in this issues were reviewed for classification, distinguish and elaboration of probabilistic/stochastic health risk analysis application in LCA. Concept of focal zone, streamlining technique, scenario modelling and Monte Carlo/Latin Hypercube risk analysis were applied to the uncertainty/variability analysis of health risk in LCA. These results show that this general framework of multi-disciplinary methodology between probabilistic health risk assessment and LCA was of benefit to decision making process by suppling information about input/output data sensitivity, health effect priority and health risk distribution. There should be further research needs for case study using this methodology.

• Journal of Information Technology Services
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• v.15 no.4
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• pp.41-62
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• 2016

In Internet of Things (IoT) era, more diverse types of information are collected and the environment of information usage, distribution, and processing is changing. Recently, there have been a growing number of cases involving breach and infringement of personal information in IoT services, for examples, including data breach incidents of Web cam service or drone and hacking cases of smart connected car or individual monitoring service. With the evolution of IoT, concerns on personal information protection has become a crucial issue and thus the risk analysis and management method of personal information should be systematically prepared. This study shows risk factors in IoT regarding possible breach of personal information and infringement of privacy. We propose "a risk analysis framework of protecting personal information in IoT environments" consisting of asset (personal information-type and sensitivity) subject to risk, threats of infringement (device, network, and server points), and social impact caused from the privacy incident. To verify this proposed framework, we conducted risk analysis of IoT services (smart communication device, connected car, smart healthcare, smart home, and smart infra) using this framework. Based on the analysis results, we identified the level of risk to personal information in IoT services and suggested measures to protect personal information and appropriately use it.

• International Journal of Knowledge Content Development & Technology
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• v.12 no.4
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• pp.41-65
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• 2022

This study would understand the overall perception of our society about public libraries, analyzing the texts related to public libraries, utilizing the semantic connection network & sentiment analysis. For this purpose, this study collected data from the last five years with keywords, 'Library' and 'Lifelong Learning Center' from January 1, 2016 through November 30, 2020 through the blogs and cafés of major domestic portal sites. With the collected data, text mining, centrality of keywords, network structure, structural equipotentiality, and sensitivity analyses were conducted. As a result of the analysis, First, 'reading' and 'book' were identified as representative keywords that form the social perception of public libraries. Second, it turned out that there were keywords related to the use of the library and the untact service due to the recent spread of COVID-19. Third, in seeking a plan for the development of public libraries through the keywords drawn to have positive meanings, it is necessary to create continuous services that can form a new image of the library, breaking away from the existing fixed role and image of the library and increase the convenience of use. Fourth, facilities and facilities for library services were recognized from a neutral point of view. Fifth, the spread of infectious diseases, social distancing, and temporary closure and closure of libraries are negatively related to public libraries, and awareness of librarians has been identified as negative keywords.

• Journal of Technology Innovation
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• v.25 no.4
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• pp.107-143
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• 2017

This study aims to understand the impact of internal and external environments and innovation efforts on a company's performance. First, the relationships and patterns between variables were determined through an exploratory factor analysis. Afterwards, a cluster analysis was conducted, in which the influential factors summarized in the factor analysis were classified. Finally, structural equation modeling was used to carry out an empirical analysis of the structural relationship between innovation efforts and the company's performance in the classified clusters. 7 factors were derived from the exploratory factor analysis of 40 input variables from external and internal environments. 4 clusters (n=1,022) were formed based on the 7 factors. Empirical analysis of the 4 clusters using structural equation modelling showed the following: Only independent technology development had a positive impact on the company's performance for Cluster 1, which is characterized by sensitivity to a technological/competitive environment and innovativeness. Only independent technology development and joint research had positive impacts on the company's performance for Cluster 2, which is characterized by sensitivity to a market environment and internal orientation. Joint research and the mediating variable of government support program utilization had positive impacts, while the introduction of technology had a negative impact on the company's performance for Cluster 3, which is characterized by sensitivity to a competitive environment, innovativeness, and willingness to cooperate with the government and related institutions. Independent technology development as well as the mediating variables of network utilization and government support program utilization had positive impacts on the company's performance for Cluster 4, which is characterized by openness and external cooperation.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.799-805
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• 2016

Background: There is no standard treatment for patients with platinum-resistant or refractory epithelial ovarian cancer. Single agent chemotherapies have evidence of more efficacy and less toxicity than combination therapy. Most are very expensive, with appreciable toxicity and minimal survival. Since it is difficult to make comparison between outcomes, economic analysis of single-agent chemotherapy regimens and best supportive care may help to make decisions about an appropriate management for the affected patients. Objective: To evaluate the cost effectiveness of second-line chemotherapy compared with best supportive care for patients with platinum-resistant or refractory epithelial ovarian cancer. Materials and Methods: A Markov model was used to estimate the effectiveness and total costs associated with treatments. The hypothetical patient population comprised women aged 55 with platinum-resistant or refractory epithelial ovarian cancer. Four types of alternative treatment options were evaluated: 1) gemcitabine followed by BSC; 2) pegylated liposomal doxorubicin (PLD) followed by BSC; 3) gemcitabine followed by topotecan; and 4) PLD followed by topotecan. Baseline comparator of alternative treatments was BSC. Time horizon of the analysis was 2 years. Health care provider perspective and 3% discount rate were used to determine the costs of medical treatment in this study. Quality-adjusted life-years (QALY) were used to measure the treatment effectiveness. Treatment effectiveness data were derived from the literature. Costs were calculated from unit cost treatment of epithelial ovarian cancer patients at various stages of disease in King Chulalongkorn Memorial Hospital (KCMH) in the year 2011. Parameter uncertainty was tested in probabilistic sensitivity analysis by using Monte Carlo simulation. One-way sensitivity analysis was used to explore each variable's impact on the uncertainty of the results. Results: Approximated life expectancy of best supportive care was 0.182 years and its total cost was 26,862 Baht. All four alternative treatments increased life expectancy. Life expectancy of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 0.510, 0.513, 0.566, and 0.570 years, respectively. The total cost of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 113,000, 124,302, 139,788 and 151,135 Baht, respectively. PLD followed by topotecan had the highest expected quality-adjusted life-years but was the most expensive of all the above strategies. The incremental cost-effectiveness ratios (ICER) of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 344,643, 385,322, 385,856, and 420,299 Baht, respectively. Conclusions: All of the second-line chemotherapy strategies showed certain benefits due to an increased life-year gained compared with best supportive care. Moreover, gemcitabine as second-line chemotherapy followed by best supportive care in progressive disease case was likely to be more effective strategy with less cost from health care provider perspective. Gemcitabine was the most cost-effective treatment among all four alternative treatments. ICER is only an economic factor. Treatment decisions should be based on the patient benefit.

• Clean Technology
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• v.26 no.1
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• pp.55-64
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• 2020

According to the Korean Renewable Energy 3020 Implementation Plan, the installation capacity of renewable energy is expected to increase whereas technology for storing excess electricity and stabilizing the power supply of renewable energy sources is extremely required. Power-to-Gas is one of energy storage technologies where electricity is converted into gas fuel such as hydrogen and methane. Basically, Power-to-Gas system could be effectively utilized to store excess electricity generated by an imbalance between supply and demand. In this study, the economic feasibility analysis of Power-to-Gas reflecting the domestic situation was carried out. Total revenue requirement method was utilized to estimate the levelized cost of hydrogen. Validation on the economic analysis method in this study was conducted by comparison of the result, which is published by the International Energy Agency. The levelized cost of hydrogen of a 100-MW Power-to-Gas system reflecting the current economic status in Korea is 8,344 won kg^-1. The sensitivity analysis was carried out, applying the main analysis economic factors such as electricity cost, electrolyser cost, and operating year. Based on the sensitivity analysis, the conditions for economic feasibility were suggested by comparing the cost of producing hydrogen using renewable energy with the cost of producing natural gas reformed hydrogen with carbon capture and storage.