• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.5
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• pp.940-944
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• 1998

This research was performed to investigate the effect of Codonopsis lanceolata water extracted on the levels of lipid in serum and liver of rats fed high fat diet for 6 weeks. Experimental groups were divided into normal group(NF), high fat diet group(HF), high fat diet and Codonopsis lanceolata water extract treated group(HFW). Codonopsis lanceolata water extract was orally administrated at the level of 0.1ml/100g body weight per day. Body weight gain and feed intake were not significantly different in three groups, but feed efficiency ratio was increased in HF and HFW. The weights of liver, kidney, heart were not significantly different among the groups. The level of serum total lipid was higher in HF than NF, but Codonopsis lanceolata water extract decreased the level of the lipid. The levels of serum triglyceride and total cholesterol were significantly increased in HF, but they were significantly decreased by administration of Codonopsis lanceolata water extract. The levels of serum HDL-cholesterol and phospholipid were slightly increased by Codonopsis lanceolata water extract. Codonopsis lanceolata water extract significantly decreased the levels of liver total lipid, triglyceride and total cholesterol which were increased by high fat diet.

• Korean Journal of Community Nutrition
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• v.2 no.1
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• pp.44-51
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• 1997

Secrum lipid and vitamin E levels were determined and smoking, alcohol drinking and exercise habits were asked in 357 healthy male subjects aged 49.4$\pm$6.7 years in Taegu. Average serum levels of total cholesterol, HDL-cholesterol and triglyceride(TG) were 189$\pm$43mg/이, 42$\pm$13mg/dl and 136$\pm$73mg/이, respectively. Serum level of lipid peroxide measured as thiobarbituric acid reactive substances(TBARS) of the subjects was 2.01$\pm$0.73MDA nmoles/ml and that of $\alpha$-tocopherol was 9.53$\pm$3.14ug/ml. The correlation coefficients between $\alpha$-tocopherol and serum lipids were 0.3631 for triglyceride, 0.2993 for cholesterol, and 0.3025 for total lipid. Heavy smokers who smoked more than 20 cigarettes a day had higher levels of TG and TBARS than those who smoke less. Alcohol drinkers had higher levels of TG and TBARS than nondrinkers. Vitamin E level(per ml serum)was significantly higher in the heavy smokers and drinkers, which was reflected by the higher level of serum lipid. When the level of $\alpha$-tocopherol was expressed as $\alpha$-tocopherol/triglyceride, it was negatively correlated with serum TBARS level and was lower in the heavy smokers than in the moderate smokers. It is concluded that vitamin E level as $\alpha$-tocopherol/triglyceride would be better compared to $\alpha$-tocopherol/total cholesterol or $\alpha$-tocopherol/total lipid for the evaluation of vitamin E status in Korean men.

• Journal of Nutrition and Health
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• v.26 no.8
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• pp.925-932
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• 1993

To study the effects of dietary protein and magnesium level on serum lipid contents and enzyme activities, male Sprague-Dawley rats were divided into six groups. Six groups of animals were fed six experimental diets different with protein(8% and 20%) and magnesium levels (Mg-free, 400mg/kg diet and 800mg/kg diet). The serum lipid contents and enzyme activities of rats fed different dietary protein and magnesium levels were examined. Serum triglyceride contents was significantly decreased as the dietary magnesium level was increased. Serum phospholipid contents was significantly higher in magnesium deficient group than those in the other groups. Serum alkaline phosphatase activity was significantly decreased in magnesium dificient group compared with other groups, but serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities was significantly increased in magnesium dificient group than other groups. In conclusion, serum triglyceride contents in low protein level was remarkably decreased as the dietary magnesium level was increased.

• Journal of Nutrition and Health
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• v.20 no.1
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• pp.46-53
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• 1987

The effect of bile deprivation on serum lipid and gastrin contents was investigat\ulcornered after choledocho-urinary cystostomy in Sprague-Dawley rats. Bile deprivated rats were compared with sham operated control group. Gastrin levels in serum and antral tissue were measured and serum lipid concentrations were also measured. Gastrin levels of serum and tissue after bile deprivation were increased significantly compared with those of the controL At the end of 1st and 2nd week after bile deprivation, serum cholesterol and triglyceride contents were significantly lower han those of the control. By 4th week, there was no significant difference between two groups. Increases in serum and antral gastrin levels temporarily coincided well with decreases in serum lipid contents after bile deprivation. These results suggest that there is increase in biosynthesis and release of gastrin and decrease in fat absorption at early stage of bile deprivation.

• Journal of Nutrition and Health
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• v.34 no.2
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• pp.132-140
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• 2001

The effects of various dietary docosahexaenoix acid(DHA) levels on the brain phospholipids and serum and liver lipid compositions were studied in rats using DHA concentrated oil and corn oil as a control for 4 weeks. Serum total cholesterol and HDL cholesterol levels tended to be the lowest by adding 20% DHA to corn oil. Serum triglyceride levels significantly decreased by adding 30% DHA. Liver cholesterol and triglyceride levels were apparently decreased in the groups added above 20% DHA, especially, the lowest at adding 30% DHA. Brain weight and phospholipid content were not different among groups. The ratios of arachidonic to linoleic acids in serum and liver phosphatidylcholine(PC) were significantly decreased by adding dietary DHA and showed a flat form above 20% of dietary DHA. DHA levels of serum PC were gradually increased according to dietary DHA level. The fatty acid compositions of the brain PC and phosphatidylethanolamine(PE) did not appear any changes with accordance of the dietary DHA levels. However, compared with those of serum and liver in general, linoleic and arachidonic acid levels were very low. Oleic acids were apparently higher than those in the other tissues. DHA were higher than those in the other tissues rigardless of the dietary DHA, especially in brain PE. The ratios of arachidonic to linoleic acid were not apparent tendency in brain PC and PE. However, the ratios of brain PE were above 2 times higher than those of brain PC. As the results, the hypolipidemic effects of dietary DNA were remarkable in liver. Especially in regard to tendency of liver lipid levels and desaturation indices in serum and liver PC, the effects indicated significantly higher by adding 20-30% DHA to diet(n-6/n-3 ratio, about 4-7). Thus, in this study, these dietary DHA levels seemed to be appropriate, at least in these lipid paramenters.(Korean J Nutrition 34(2) : 132∼140, 2001)

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.115-120
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• 2019

This study was undertaken to determine the correlation between β-amyloid, serum lipid levels, and cognitive function in the elderly with mild Alzheimer's dementia. The study was conducted in December 2018, enrolling 45 elderly people with mild Alzheimer's disease. Blood analysis measured the β-amyloid and serum lipid levels, and cognitive function was measured using MMSE-K. The correlation between β-amyloid, serum lipid levels and cognitive function was determined using Pearson's correlation analysis. A significantly negative correlation was observed between the β-amyloid level and cognitive function (p<0.05). Furthermore, serum lipid levels and cognitive function also revealed a significantly negative correlation between TC and LDL levels (p<0.05). These results indicate that increasing levels of β-amyloid, TC, and LDL augments a negative correlation that decreases the cognitive function, signifying that management of pathologic factors related to dementia is important for the prevention and improvement of cognitive function in dementia patients.

• Journal of Nutrition and Health
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• v.26 no.5
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• pp.558-565
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• 1993

This study was carried out to observe the effects of dietary n-6, n-3 fatty acids and vitamin A levels on serum lipid contents and hepatic tissues in rats. Sixty eight male Sprague-Dawley rats were fed 6 different experimental diets for 6 weeks. The diets were composed of 10% of either corn oil or fish oil with three levels of vitamin A ; defient (1240IU/kg diet), adequate (4000IU/kg diet), excess(400,000IU/kg diet). It was observed that triglyceride content and lipoprotein ratio in serum were not affected by dietary fat types and vitamin A levels. However, total serum cholesterol contents were significantly lower in fish oil groups than in corn oil groups, which were not affected by vitamin A levels. Under light microscope, vitamin A excess groups showed pathological abnormalites, such as fatty change and inflammation of the hepatic tissues. There abnormalities were less severe in fish oil groups. These results suggested that fish oil could be a dietary factor lowering the serum lipid contents, and it seems to relieve the abnormal changes in liver induced by excess vitamin A.

• Journal of Nutrition and Health
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• v.31 no.3
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• pp.315-323
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• 1998

This study was performed to investigate the serum lipid levels and fatty acid composition in middle-aged men and the influence of cardiovscular risk factors on them. Data for dietary intake, anthropometry , blood pressure, and general environmental factors were obtained and their relationship to serum lipid levels and fatty acid composition were analyzed in 303 healthy male subjects with a mean age of 43.8$\pm$6.4 years from June 1 to 22 , 1995. The prevalence of obesity was 26.7% by BMI and 11.2% by WHR criteria . The percentage of hypertensive subjects were 13.5% and 22.4% by systolic and diastolic blood pressure, respectively. Retinol, calcium , and roboflavin intakes were lower than the RDA for Koreans. The ratio of carbohydrate intake to total calories of the subjects was 70%. Ratios of P/M and n-6/n-3 were 1.02/1.05/1.00 and 11.1/1, respectively. The percentage of subjects who had serum TG, TC, LDL-C leves beyond the normal range were 19.5% , 13.5% and 8.6% respectively. Palmitic comprised 26.4% of serum total fatty acids, linoleic acid 19.4% and oleic acid 16.4. The waist circumference and ration of carbohydrate intake were related positively to TG level. Serum cholesterol level had positive relations with waist circumference, DBP, sugar intake, and income. There were positive relationships between SFA and bone fishes and vegetable oil intakes, MUFA and DBP while a negative a negative relationship was observed between PUFA and animal fat intake. Serum n-6 fatty acid was related negatively to carbohydrate intake and hot taste preference. N-3 fatty acid was related positively to fish intake and negatively to egg intake. These results suggest that to maintain adequate serum lipid levels and fatty acid composition, sugar, animal fat, and carbohydrate intakes have to be reduced, while consumption of vegetable oil and fish must be increased. It is also essential to control abdominal fat accumulation and blood pressure.

• Journal of the East Asian Society of Dietary Life
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• v.8 no.1
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• pp.9-19
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• 1998

The purpose of this study was to investigate the effect of calcium intake on lipid contents and enzyme activities in rats of different ages. Lipid levels in serum and liver and GOT, CPK and LDH activities in serum were compared in rats of different ages(4 weeks and 10 months) that were fed various levels of calcium(50, 100, 200% of requirement)for 3 weeks. Body weight gain and feed efficiency ratio were significantly higher in young rats than in adults. Serum calcium level was increased by elevation of calcium intake levels were decreased. Liver phospholipid and triglyceride levels in the high-cal-terol and triglyceride levels were decreased. Liver phospholipid and triglyceride levels in the high calcium group were significantly lower than those in other groups. Serum GOT and LDH activities of adults were significantly higher in low-calcium group than those in adequate/high-calcium groups. However, serum CPK activity of adults was significantly higher in high-calcium group than that in low/adequate-calcium groups. The results of this study suggest that adequate calcium intake may have protective effects ont he alteration of lipid and enzyme activity in rats.

• The Korean Journal of Pharmacology
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• v.17 no.2
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• pp.69-74
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• 1981

Increased incidence of myocardial infarction, arteriosclerosis and hypertension in oral contraceptive steroids users has been recognized as serious problem. Evidence have been accumulated that oral contraceptive steroids cause an increase in serum lipid levels, mainly triglyceride as well as an increase in serum cholesterol concentration in some women. Effect of oral contraceptives on serum lipids have been predominantly confirmed in Europian and American women. It should be emphasized that effects of contraceptives may he influenced by differences in nutrition, climate, socioeconomic status and race. The present study was, therefore, attempted to determine the effect of oral contraceptive steroids on serum lipid levels in Korean women and also to demonstrate whether the duration of pill treatment may affect serum lipid levels. Ten women, who had never taken contraceptive steroids, served as a control. One hundred women on combined oral contraceptive steroids were grouped according to the duration of pill use: duration of less than one year(14 women), 1-2 years(12 women), 2-5 years(29 women), 5-10 years(33 women) and more than 10 years(13 women). Serum levels of cholesterol, phosholipid and triglyceride were measured by enzymatic method, Fiske-SubbaRow method and Sugiura method respectively. The results obtained are as follows; 1) Oral contraceptive steroids increased serum cholesterol concentration by 4.8% as compared with cholesterol value of control group. But this increase was not statistically significant. 2) As compared with control value, concentration of serum phospholipid in pill-treated women decreased by 14.3%, which was statistically significant (p<0.05). 3) Concentration of serum triglyceride in pill-treated women increased by 10.6% over control value, but this increase was not statistically significant. 4) Duration of pill-treatment did not affect serum concentrations of cholesterol, phospholipid and triglyceride. From the results mentioned above, it may be concluded that combined oral contraceptive steroids, at least used for subjects involved in this study, decreased serum phospholipid significantly, thereby influencing serum lipid concentration.