• Title/Summary/Keyword: spinal cord injury

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Improvement of Functional Recovery by Cell Transplantation after Spinal Cord Injury (척수손상 후 세포이식에 의한 운동기능의 회복증진)

  • 이배환;이경희;성제경;황세진;김계성
    • Science of Emotion and Sensibility
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    • v.7 no.2
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    • pp.179-186
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    • 2004
  • Acute spinal cord injury can produce neurologic injury with many physical, psychological and social ramifications. It has been shown that two separate components combine to produce neurologic damage in acute spinal cord injury : the primary and secondary injuries. The primary mediators of spinal cord injury include the actual mechanical tissue disruption which is a passive process that occurs immediately following the trauma. A secondary injury cascade follows which appears mediated by cellular and molecular processes working through complex mechanisms. Both the primary and secondary injury cascades produce cell death both in neuronal and supporting cell tissues. Recovery from central nervous system(CNS) disorders is hindered by the limited ability of the vertebrate CNS to regenerate injured cells, replace damaged myelin sheath, and re-establish functional neuronal connections. Of many CNS disorders including multiple sclerosis, stroke, and other trauma, spinal cord injury is one of the important diseases because of the direct association with the functional loss of the body. Previous studies suggest that substantial recovery of function might be achieved through regeneration of lost neuronal cells and remyelination of intact axon in spinal cord injury which is occurred frequently. As a therapeutic approach in spinal cord injury, recently, cell transplantation provides a potential solution for the treatment of spinal cord injury. This review describes the characteristics of spinal cord injury and presents some evidence supporting functional recovery after cell transplantation following spinal cord injury.

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Role of Dehydrocorybulbine in Neuropathic Pain After Spinal Cord Injury Mediated by P2X4 Receptor

  • Wang, Zhongwei;Mei, Wei;Wang, Qingde;Guo, Rundong;Liu, Peilin;Wang, Yuqiang;Zhang, Zijuan;Wang, Limin
    • Molecules and Cells
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    • v.42 no.2
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    • pp.143-150
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    • 2019
  • Chronic neuropathic pain is one of the primary causes of disability subsequent to spinal cord injury. Patients experiencing neuropathic pain after spinal cord injury suffer from poor quality of life, so complementary therapy is seriously needed. Dehydrocorybulbine is an alkaloid extracted from Corydalis yanhusuo. It effectively alleviates neuropathic pain. In the present study, we explored the effect of dehydrocorybulbine on neuropathic pain after spinal cord injury and delineated its possible mechanism. Experiments were performed in rats to evaluate the contribution of dehydrocorybulbine to P2X4 signaling in the modulation of pain-related behaviors and the levels of pronociceptive interleukins and proteins after spinal cord injury. In a rat contusion injury model, we confirmed that chronic neuropathic pain is present on day 7 after spinal cord injury and P2X4R expression is exacerbated after spinal cord injury. We also found that administration of dehydrocorybulbine by tail vein injection relieved pain behaviors in rat contusion injury models without affecting motor functions. The elevation in the levels of pronociceptive interleukins ($IL-1{\beta}$, IL-18, MMP-9) after spinal cord injury was mitigated by dehydrocorybulbine. Dehydrocorybulbine significantly mitigated the upregulation of P2X4 receptor and reduced ATP-evoked intracellular $Ca^{2+}$ concentration. Both P2XR and dopamine receptor2 agonists antagonized dehydrocorybulbine's antinociceptive effects. In conclusion, we propose that dehydrocorybulbine produces antinociceptive effects in spinal cord injury models by inhibiting P2X4R.

The Clinical Study On 1 Case for The sensation of patient with Spinal Cord Injury whose is improved by using sweet BV (Sweet BV 병행 치료 후 척수 손상 환자의 감각 분절 호전 1례)

  • Park, In-Sun;Yoon, Il-Ji
    • Journal of Pharmacopuncture
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    • v.12 no.2
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    • pp.77-84
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    • 2009
  • Objective : Patients with spinal cord injury are increasing in numbers. However, there is no reliable treatment guide in both conventional & complementary medicine. Also, there are not much clinical case of patients with spina cord injury in oriental medical field. We investigated effect of sweet BV on subacute stage patient with spinal cord injury. Method : 31-year old female patient with spinal cord injury was treated with herb medicine(TID), electro arcupunture (BID), sweet BV injection(QOD), Physical treatment(QD), and conventional-medicine. Result : We had a satisfactory result with using sweet BV injection. The patient's ASIA grade improved from 34 to 52. And Frankle classification of the patient shifted from A to B. Conclusion : We reach a conclusion Using Sweet BV improve the sensation of patient with spinal cord injury. And more study about this disease is needed.

Sexual Adjustment Process of Individuals with Spinal cord Injury (척수 장애인의 성적 적응 경험)

  • Kang, Hyun-Sook;Koh, Jung-Eun;Suh, Yeon-Ok;Yee, Oon-Hee
    • The Korean Journal of Rehabilitation Nursing
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    • v.3 no.1
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    • pp.80-97
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    • 2000
  • The purpose of this study is to identify and describe a process of sexual adjustment of individuals with spinal cord injury: and to describe and explore positive and negative influences on the adjustment process. This qualitative study was conducted with 10 Korean individuals with spinal cord injury who had been physically disabled for more than one year. Data were collected and analysed at a same time using grounded theory method. Major categories of this study showed a process how the individuals with spinal cord injury adjust to their individual life as sexual beings. The process included and individual responses to the behavioral efforts including and . Initially physical aspects of sexuality seemed to be affected by spinal cord injuries. The changed physical aspects then influenced other aspects of their sexual life. Life satisfaction of each individual as a sexual being revealed as very subjective. It could be defined according to how the individual approved their sexual life no matter what and how much behavioral effort the person had done. In this study 3 types of sexual adjustment aspects were explored: 'Active adjustment' 'Passive adjustment' 'Maladjustment'. There were negative and positive factors influencing the adjustment process of individuals with spinal cord injury. Those factors might come from themselves, from families, or from social situations. Findings of this study suggested that sexual life of individuals with spinal cord injury should not be understood as a physical or behavioral matter. It was a combination of physical, psychological and social aspects of life. Therefore, appropriate rehabilitation programs for the sexual adjustment of individuals with spinal cord injury need to concern heterogeneous life values of them and obtain individualized services for each individual at a different stage of the sexual adjustment process.

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Development of Home Care Nursing Intervention Protocols for Spinal Cord Injury Patients Based on NIC (NIC에 근거한 척수손상환자의 가정간호 중재 프로토콜 개발)

  • Moon, Seong-Mi;Kim, Sun-Hee
    • Journal of Korean Academic Society of Home Health Care Nursing
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    • v.8 no.1
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    • pp.25-37
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    • 2001
  • Spinal cord injury patients need rehabilitation after the acute stage. They should be cared for at home to decrease hospitalization. Home care nurses play an important role in making spinal cord injury patients who have physical. and psychosocial problems do their best. For effective care, home care nurses need standardized nursing intervention protocols for spinal cord injury patients, but they are rarely developed. Therefore, this study was conducted to develop home care nursing protocols, based on NIC, that are applicable to spinal cord injury patients at home. Forty home care nursing charts of spinal cord injury patients registered in a home care nursing agency from July 1st, 1994 to August 31st, 1999 in S city were analyzed. Fifteen home care nurses participated in this study as a user validity validation group, The results of this study are as follows. 1. Fifteen nursing diagnoses were classified through the frequency analysis of home care nursing charts and previous literature for 40 spinal cord injury patients: altered urinary elimination, constipation, high risk for impaired skin integrity, chronic pain, impaired skin integrity, impaired social interaction, knowledge deficit, bowel incontinence, high risk for injury, altered role performance, care giver role strain, impaired physical mobility, sexual dysfunction, dysreflexia, and ineffective breathing pattern. 2. Based on validation by experts and user validities, 93 nursing interventions which were above ICV(Index of Content Validity) .80 were chosen. 3. Nursing intervention protocols which showed above ICV .80 were developed.

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The Clinical Study on Hua-Tuo-Jia-Ji-Xue Acupuncture Treatment to Neuropathic Pain of Patients with Spinal Cord Injury (척수손상 환자의 신경인성 통증에 대한 협척혈(夾脊穴) 침치료(鍼治療) 증례보고 5례)

  • Nam, Jong-Kyung;Lee, Myeong-Jong;Kim, Ho-Jun
    • Journal of Korean Medicine Rehabilitation
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    • v.20 no.2
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    • pp.183-190
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    • 2010
  • Objectives : This study was designed to evaluate clinical effects of Hua-Tuo-Jia-Ji-Xue acupuncture treatment to neuropathic pain of patients with spinal cord injury. Methods : The clinical study was carried out 5 cases with spinal cord injury, who had been treated from December, 2008 to November, 2009 in the department of oriental rehabilitation medicine, Dong-Guk university oriental medical hospital. Results : After treating Hua-Tuo-Jia-Ji-Xue acupuncture, we find out that the VAS(Visual Analog Scale) score was significantly improved after treatment. Conclusions : These result suggest that Hua-Tuo-Jia-Ji-Xue acupuncture were effective to neuropathic pain of spinal cord injury patients.

Case study of Oriental Medicine Treatment with Mae-sun therapy of the spinal cord injury due to lumbar burst fracture (방출성 요추 골절로 인한 척수손상 환자에 대해 매선요법을 가미한 한방치료를 시행한 치험례)

  • Kwon, Gi-Sun;Park, Jung-Ah;Noh, Ju-Hwan;Kim, Cheol-Hong
    • Journal of Pharmacopuncture
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    • v.13 no.1
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    • pp.129-144
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    • 2010
  • Objective : Traumatic lumbar burst fracture causes significant spinal cord injury. This report is intended to estimate the efficacy using oriental treatment on a patient with lumbar burst fracture and spinal cord injury. Methods : From 21th December, 2009 to 5th February, 2010, 1 female inpatient diagnosed with lumbar burst fracture and spinal cord injury was treated with general oriental medicine therapy : mae-sun therapy ; acupuncture ; moxibustion ; pharmacopuncture ; physical therapy and herbal medication. TUG, SCIMII and VAS were used for evaluation of gait disturbance and pain in both feet. Measurement of self voiding amount and remaining amount through CIC was used for evaluation of neurogenic vesical dysfunction. Results : The patient showed a certain degree of improvement in gait disturbance, pain in both feet and neurogenic vesical dysfunction through above evaluation methods. Conclusion : Oriental treatments such as mae-sun therapy, acupuncture and moxibustion therapy, pharmacopuncture therapy and herbal medication can be effective for spinal cord injury due to traumatic lumbar burst fracture.

A Case Report of Complex Korean Medical Treatment for Cervical Spinal Cord Injury and Neurogenic Bladder (한의복합치료 후 호전된 경부척수손상 환자의 사지마비 및 신경인성 방광: 증례보고)

  • Song, Min-Yeong;Jo, Hee-Guen;Kim, Tae-Gwang;Choi, Jin-Bong
    • Journal of Korean Medicine Rehabilitation
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    • v.26 no.3
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    • pp.143-151
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    • 2016
  • A 57-year-old male patient was diagnosed as Incomplete cervical spinal cord injury and Neurogenic bladder after falling accident and suffered from tetraplegia and urinary retention. The patient was hospitalized and treated with Complex Korean Medical treatment such as acupuncture, electro-acupuncture, bee venom pharmacopuncture and herbal medication for 13 weeks. International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) was adopted to evaluate the functional recovery and Korean version of Modified Barthel Index (K-MBI) was adopted to evaluate the recovery of activities of daily living (ADL). After treatment, Total scores of ISNCSCI and K-MBI were improved. Also patient's micturition reflex was recovered and symptoms of neurogenic bladder were improved. This result shows that Korean Medical treatment may be an effective treatment option for spinal cord injury and neurogenic bladder patients. Further clinical studies are needed to clarify the effect of Korean Medical treatment on spinal cord injury.

Effects of Elastic Resistance Exercise Using Proprioceptive Neuromuscular Facilitation on Activities of Daily Living of Patient with Incomplete Spinal Cord Injury -Single Subject Design- (PNF에 기초한 탄력저항운동이 불완전 척수 손상 환자의 일상생활동작에 미치는 효과 -단일사례연구-)

  • Kim, Jwa-Jun;Kim, Min-Soo
    • PNF and Movement
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    • v.14 no.3
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    • pp.245-254
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    • 2016
  • Purpose: This study investigates the influence of elastic resistance exercise using proprioceptive neuromuscular facilitation (PNF) on the daily activities of a patient with incomplete spinal cord injury. The result will be proposed as background data for effective intervention in a patient with incomplete spinal cord injury. Methods: The target subject was a patient with incomplete spinal cord injury to the cervical cord (C6). Elastic resistance exercise based on PNF was performed for 30 min daily, five times a week, for eight weeks. The ASIS motor scale was applied to test the muscular strength of the upper limb, and the spinal cord independence measure II (SCIM II) was used to evaluate the capacity of daily activity. Results: By applying elastic resistance exercise based on PNF, the muscular strength of the upper limb increased and the performance of daily activity improved. Conclusion: Because elastic resistance exercise based on PNF positively influences the ASIA motor scale and SCIM II of the patient with incomplete spinal cord injury. It can be used for training programs to improve the capacity of daily activity of the patient.

Isokinetic Evaluation Comparison of Shoulder Girdle Muscles in the Spinal Cord Injury Group and Normal Young Adults Group (척수 손상 환자와 정상 성인과의 견관절 주위근에 대한 등속성 근력 평가 비교)

  • Moon, Sung-Ki;Chae, Soo-Sung
    • Journal of Korean Physical Therapy Science
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    • v.2 no.1
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    • pp.367-373
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    • 1995
  • The purpose of this studied was the comparison with shoulder girdle muscles of isokinetic evaluation in the spinal cord injury group, and adults normal group. Data was collected from 20 cases spinal cord injury from January 10. 1994 to February 10, 1995 in a Chungnam University hospital and adults normal group to 20 cases. The results were as follows; 1. Low speeds peak torque was higher spinal cord group than normal group shoulder girdle muscles of flexor, extensor, external rotator showed statistically significant in spinal cord injury group(p<0.05). Against normal groups shoulder girdle muscles of internal rotator showed statistically significant in normal group(p<0.05). 2. High speeds peak torque was higher spinal cord group than normal group shoulder girdle muscles of flexor, extensor, showed statistically significant in spinal cord injury group(p<0.05). 3. High speeds total work was higher spinal cord group than normal group shoulder girdle muscles of flexor, extensor, external rotator showed statistically significant in spinal cord injury group(p<0.05).(p<0.01). Against normal group shoulder girdle muscles of internal rotator showed statistically significant in normal group(p<0.05).

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