• Journal of Pharmaceutical Investigation
• /
• v.20 no.2
• /
• pp.97-103
• /
• 1990

The metastable modification of acetaminophen was prepared in industry scale. It was found that the dissolution rate of the metastable modification was greater than that of the original powder. The metastable modification was transformed to the stable modification by grinding, but it was not transformed by compression. Starch and lactose inhibited this transformation of the metastable modification to the stable modification by grinding.

• Journal of Pharmacopuncture
• /
• v.25 no.3
• /
• pp.224-232
• /
• 2022

Objectives: Routine therapies cannot control refractory stable angina, leading to a high economic burden and an impaired quality of life. Persian medicine incorporates exceptional attention to lifestyle and nutrition to prevent and treat various diseases. Previous studies have reported the analgesic and anti-inflammatory effects of wet cupping. The present study aims to determine the effects of nutrition and cupping on refractory stable angina patients. Methods: Forty male patients with refractory stable angina were randomly allocated to four groups, including nutrition modification based on Persian medicine, wet cupping, nutrition modification along with wet cupping, and control. The primary outcomes were the changes in pain score using a visual analog scale and quality of life using the Seattle angina questionnaire. The secondary outcomes were changes in the exercise test and blood pressure. Results: The results of the present study revealed that 30 days of treatment with nutrition modification based on Persian medicine, cupping, and modified nutrition and cupping along with standard treatment for stable angina significantly increased the patient's quality of life and exercise test results while reducing pain, and systolic and diastolic blood pressure. Conclusion: Applying complementary Persian medicine methods such as nutrition modification and cupping along with the classical medical treatments may improve outcomes for refractory stable angina patients.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
• /
• 2004.09a
• /
• pp.273-276
• /
• 2004

The adhesion of hydrocarbon degrading bacteria(HDB) differing in surface hydrophobicity was investigated. Cell wall hydrophobicity was modified chemically and physiologically. Modified adhesion deficient mutant of HDB was selected in a soil column assay. Physiologically and chemical modification increased cell surface hydrophobicity. Cell surface characteristics including BATH and FTIR were measured. Physiological modification using ampicillin was not stable, but chemical modification was stable. Hydrocarbon degrading efficiency was measured of TPH modified and unmodifed HDB.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.12 no.1
• /
• pp.72-77
• /
• 2003

The stable driving condition of high speed gear is approached by shape modifications of a gear tooth. Recently, many gear designers are using FEM for the design and the manufacture of a high precision gear. In this paper, it is aimed to drive in stable sound level through the modification of the tooth and the shape of a gear. The simulation is used to understand the effect of holes for the decrement of weight and the stress variation for the tooth modification. Beam elements used to simulate the same condition as a real gear drive by FEM. The driven gear is simulated to 60,000rpm for the tooth modification.

• Proceedings of the Korean Society for Agricultural Machinery Conference
• /
• 1993.10a
• /
• pp.1026-1035
• /
• 1993

Further evaluation and modification were done on the new concepts plow (frontal plow), a plow which inverts the soil furrow without lateral displacement . First, kinematics of soil cutting section was analyzed and an experiment was conducted to report draft and power requirement. Second, function of main moldboards was examined and modification was made. As a result of the modification , force applied to the moldboard was reduced, but the furrow inversion became less stable.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 2001.05a
• /
• pp.43-46
• /
• 2001

We, in this paper, design the Sugeno-models fuzzy controller by using the membership function modification algorithm and ANFIS, which are clustering and learning the input-output data. The membership function modification algorithm constructs the more concrete fuzzy controller by clustering the input-output data from the fuzzy inference system. ANFIS construct the Sugeno-models fuzzy controller by learning the input-output data from the above controller. We showed that the fuzzy controller designed by our method could have the stable learning and the enhanced performance.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
• /
• 2003.09a
• /
• pp.360-362
• /
• 2003

The adhesion of hydrocarbon degrading bacteria(HDB) differing in surface hydrophobicity was investigated. Cell wall hydrophobicity was modified chemically and physiologically. Modified adhesion deficient mutant of HDB was selected in a soil column assay Physiologically and chemical modification increased cell surface hydrophobicity. Cell surface charcteristis including BATH and zeta potential were measured. Physiological modification using ampicillin was not stable, but chemical modification was stabel. Hydrocarbon degrading potential was measured for modified and unmodifed HDB.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2017.05a
• /
• pp.244-245
• /
• 2017

This study aims to develop high durability graphene / epoxy paint for durability improvement of construction structure. For the development of graphene / epoxy coatings, first, graphene must remain stable in the polymer. Second, the integrity of graphene and polymer should be ensured. Accordingly, in order to obtain dispersibility, surface modification of graphene nanoplate(GnP) with CH and COOH functional groups and its dispersibility in organic solvents were investigated. Also, Fourier Transform Infrared Spectroscopy(FT-IR) analysis and Atomic Force Microscope(AFM) analysis were performed to confirm whether the functional groups were synthesized by surface modification. As a result, FT-IR and AFM analysis did not confirm the surface modification, but GnP was found to be stable when dispersed in an organic solvent.

• Bulletin of the Korean Mathematical Society
• /
• v.38 no.1
• /
• pp.29-53
• /
• 2001

This note presents a an indirect adaptive control scheme for first-order continuous-time systems. The estimated plant model is controllable and then the adaptive scheme is free from singularities. The singularities are avoided through a modification of the estimated plant parameter vector so that its associated Sylvester matrix is guaranteed to be nonsingular. That properties is achieved by ensuring that the absolute value of its determinant does not lie below a positive threshold. A modification scheme based on the achievement of a modified diagonally dominant Sylvester matrix of the parameter estimates is also given as an alternative method. This diagonal dominance is achieved through estimates modification as a way to guarantee the controllability of the modified estimated model when a controllability measure of the ‘a priori’ estimated model fails. In both schemes, the use of a hysteresis switching function for the modification of the estimates is not required to ensure the nonsingularity of the Sylvester matrix of the estimates.

• Animal cells and systems
• /
• v.12 no.3
• /
• pp.117-125
• /
• 2008

One of the interesting trends in genome research is the study about epigenetic modification above single gene level. Epigenetics refers study about heritable change in the genome, which accompany modification in DNA or Chromatin besides DNA sequence alteration. We used to have the idea that the coding potential of the genome lies within the arrangement of the four bases A, T, G, C; However, additional information that affects phenotype is stored in the distribution of the modified base 5-methylcytosine. This form of information storage is flexible enough to be adapted for different somatic cell types, yet is stable enough to be retained during mitosis and/or meiosis. Epigenetic modification is a modification of the genome, as opposed to being part of the genome, so is known as "epigenetics"(Greek for "upon" genetics). This modification could be methylation on Cytosine base or post translational modification on histone protein(methylation, acetylation, phosphorylation, Sumoylation)($Dimitrijevi\hat{E}$ et al 2005). In this review, we would like to focus on the relationship of DNA methylation and cancer.