• Archives of Pharmacal Research
• /
• 제14권4호
• /
• pp.295-297
• /
• 1991

E. creticum has been used in folk medicine in Jordan as a remedy for scorpion stings in the rural areas and as a hypoglycemic agent. The hypoglycemic activity of an aquous decoction of plant arial parts of E. creticum was tested in normoglycemic and streptozocin-hyperglycemic rats. Results indicate that those extract caused significant reductions in blood glucose concentration when given orally.

• 약학회지
• /
• 제44권3호
• /
• pp.251-256
• /
• 2000

Sterically stabilized liposomes (SSL) composed of distearoylphosphatidylcholine, cholesterol, dicetylphosphate and distearoylphosphatiodylethanolamine-N-poly(ethyleneglycol) 2000 (DSPE-PEG 2000) were made by reverse phase evaporation method to prolong biological half-life and decrease toxic side effect of drug. Streptozocin (572), a water-soluble antitumor agent with short half-life, was selected as a model drug. The size of SSL was controlled by polycarbonate extrusion to 100 nm which is adequate size for long circulation in plasma. The release rate of drugs from SSL in PBS was evaluated. And the stability of STZ-containing liposomes against drug leakage into rat plasma was evaluated in order to investigate the interaction of liposome and plasma protein. Incorporation of DSPE-PEG 2000 into conventional liposomes significantly decreased the drug leakage into rat plasma.

• 대한의생명과학회지
• /
• 제11권3호
• /
• pp.343-347
• /
• 2005

Bambusae caulis in Liquamen is one of the important herbal medicine produced by heating bamboo indirectly and is used for treatment of stroke, hypertension, and diabetes etc. Recently the mechanism of clinical effects on Bambusae caulis in Liquamen has been studied. This experiment was conducted to confirm the clinical effects of Bambusae caulis in Liquamen on type 1 diabetes and its related mechanism. We divided C57BL/6 mice into 3 groups and induced them to be type 1 diabetes by injection of streptozocin into peritoneum. The dosage of each group was 150 mg/kg once only, 140 mg/kg once only and 40 mg/kg for 5 days respectively. The two groups injected streptozocin for once took orally Bambusae caulis in Liquamen after the induction of diabetes, and the other one group was given Bambusae caulis in Liquamen during the diabetes inducing period. As the result, the two diabetes-induced groups showed blood glucose decreasing effect by Bambusae caulis in Liquamen on an average, but they didn't show the signiftcant differences statistically. But Bambusae caulis in Liquamen showed the anti-diabetic effect suppressing blood sugar rising trend during the diabetes inducing peried (P<0.05). The anti-oxidative effect of Bambusae caulis in Liquamen was measured with the hypoxanthine/xanthine oxidase (HX/XOD) system. The quantity of ROS was measured using DCFDA reagent indirectly. As the result, $10\%$ solution of Bambusae caulis in Liquamen showed anti-oxidative effect by scavenging $93.4\%$ superoxide as compared with control group. It is suspected that the anti-oxidative effect of Bambusae caulis in Liquamen suppressed the increase of blood glucose in the diabetes-inducing group. These results could be useful data to understand the effect of Bambusae caulis in Liquamen on type 1 diabetes and type 1 diabetes developing because ROS were closely connected with the induction and complications of diabetes.

• 대한한의학회지
• /
• 제15권2호
• /
• pp.429-444
• /
• 1994

The present study was undertaken in order to elucidate the effect of pretreatment with Saengchinyanghyoltang(SYT) on changes in serum glucose level, body weight. water consumption. serum insulin concentration and activities of pancreatic enzymes in rats treated with streptozocin(STZ)-induced diabetic state. Histological studies were also carried out to elevate the effects on pancreatic tissues and Langelhans islet cells. SYT pretreatment in STZ diabetic rats inhibited the rise of fasting serum glucose concentration and water consumption. Pretreatment with SYT significantly increased the concentration of blood insulin and body weight changes compared to the STZ-treated group. Pancreatic lipase and trypsin activities were increased. but amylase activity was decreased and pancreatic ${\beta}-cell$ was destroyed by STZ but. pretreatment with SYT prevented these STZ-induced changes.

• 한국식품영양과학회지
• /
• 제38권9호
• /
• pp.1179-1186
• /
• 2009

이가 식이효율(FER), glucose, creatinine, cholesterol, triglycetide, HDL-cholesterol, 동맥경화지수(AI) 등에 미치는 영향을 조사하였다. 식이효율은 정상군이 5.94%로 가장 높았고, 당뇨대조군은 0.58%로 정상군에 비해 현격한 감소를 보였다. DA군과 DB군은 각각 3.65%, 3.38%로 다른 투여군보다 상대적으로 높은 수준의 식이효율을 보였다. 혈당변화를 측정한 결과 투여 전에 비해 DA군은 41%, DB군은 24.8%, DC군은 31.2%, DDL군은 18.6%, DDH군은 25.5%의 혈당 감소효과를 보였다. 생맥산 투여 전 creatinine 함량은 정상군에 비하여 당뇨 유발군에서 상승을 보였으며, DB군은 투여 후 33.3%의 유의적인 감소(p<0.05)를 보였고, 그 외의 군(DA, DC, DDL, DDH)에서는 유의적인 변화가 없었다. 혈청 내 cholesterol 수치의 유의적인 상승을 보인 당뇨 유발군과 비교하여 생맥산을 14일간 투여한 모든 군에서 cholesterol 수치의 유의적인 감소를 보였다. 당뇨 유발군에서 유의적인 상승을 보인 혈청 triglyceride는 DC군에서 수치가 감소하였지만 유의적인 차이는 없었다. HDL-Chlolesterol은 DA, DB, DC군에서는 유의적인 변화는 나타나지 않았다. 반면 DDL군과 DDH군에서의 HDL-chlolesterol은 투여 전과 후 각각 41.81$\pm$2.28 mg/dL, 40.75$\pm$0.48 mg/dL에서 50.59$\pm$2.77, 49.93$\pm$1.17 mg/dL로 유의적인 증가를 나타냈다. Atherogenic index(AI)를 측정한 결과 투여 전에는 당뇨유발군의 AI 수치가 정상군과 비교 시 모든 그룹에서 상승하였으나, 투여 14일 후 측정결과 DA, DB, DC군에서 정상군에 가깝게 수치가 낮아진 것을 확인했다. 또한 DDL군과 DDH군은 유의적인 AI지수의 감소를 나타냈으며 압출성형 백삼을 이용한 생맥산의 식이가 동맥경화의 예방에 상당한 효과가 있는 것으로 판단된다. 이상의 결과를 종합해 보면 STZ로 유도된 당뇨 rat에서 생맥산의 식이는 FER의 개선에 상당한 효과를 보이며, 고혈당을 억제시키고 정상수준의 혈당으로 회복하는데 영향을 미치는 것으로 여겨진다. 또한 발효시킨 백삼을 이용한 생맥산 투여군에서는 신장 기능의 지표인 creatinine의 함량을 낮추고 지질수준의 감소를 보여 당뇨의 증상을 완화시키고 동맥경화증과 같은 혈액 순환기계 질환의 예방에 효과적인 건강보조식품으로 사용될 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권6호
• /
• pp.2151-2159
• /
• 2015

Pancreatic neuroendocrine tumors (pNETs) are rare and heterogenous tumors and surgery to remove the primary tumor is the mainstay of treatment for resectable disease. However, curative surgery is often not feasible, because half of patients with pNET have metastases at the time of diagnosis. Palliative dubulking surgery and liver-directed therapies are appropriate options for these patients. Streptozocin-based regimens are standard, although temozolamide-based treatments are rapidly gaining wide clinical application. Somatostatin analogs are mainly indicated in hormonally active tumors to ameliorate symptoms. In addition, anti-tumoral activity has been proven in well-differentiated NETs. Recently, there has been tremendous progress in the molecular biology of pNETs; thereby, the efficacy of sunitinib and everolimus in the treatment of patients with metastatic pNETs has been proven by large placebo-controlled phase III trials. Currently, there are no definitively proven predictive biomarkers to evaluate response to medical therapies in patients with pNET. Therefore, further studies are needed to individualize and optimize their management. This article reviews systemic chemotherapy, targeted therapies, and anti-secretory treatments for the management of patients with unresectable or metastatic pNETs, summarized in the light of recent advances.

• Nutrition Research and Practice
• /
• 제7권5호
• /
• pp.359-365
• /
• 2013

Anthocyanin from purple sweet potato (PSP) extracted by microwave baking (MB) and acidified electrolyzed water (AEW) exhibited antioxidant activity. After further purification by macroporous AB-8 resin, the color value of PSP anthocyanin (PSPA) reached 30.15 with a total flavonoid concentration of 932.5 mg/g. The purified extracts had more potent antioxidant activities than the crude extracts. After continuously administering the PSP extracts to 12-mo-old mice for 1 mo, the anti-aging index of the experimental group was not significantly different from that of 5-mo-old mice. To a certain degree, PSPA was also effective for controlling plasma glucose levels in male Streptozocin (STZ)-treated diabetic mice. In addition, the extracts inhibited Sarcoma S180 cell growth in ICR mice. Mice consuming the PSP extracts formed significantly fewer and smaller sarcomas than mice consuming the control diets. The highest inhibition rate was 69.03%. These results suggest that anthocyanin extracts from PSP not only exert strong antioxidant effects in vitro, but also had anti-aging, anti-hyperglycemic, and anti-tumor activities.

• Applied Microscopy
• /
• 제43권2호
• /
• pp.54-64
• /
• 2013

The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, ${\beta}$-cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues were also vividly recorded. In the STZ+rutin administered group, the heart and retina tissues were shown to be preserved normally while the liver and kidney tissues showed reduced histopathology in general compared to the STZ-treated group. Conclusionally, the rutin has the effect on the antioxidant activities and anti-inflammation in the STZ-induced diabetic rats.

• Journal of Pharmaceutical Investigation
• /
• 제31권1호
• /
• pp.43-47
• /
• 2001

Sterically stabilized liposomes (SSL) have been introduced for longer circulation in blood than conventional liposomes (CL). However, there are a couple of problems in SSL preparation due to the instability of phospholipid and the degradation of drug in aqueous conditions. To solve these problems, it is necessary to go through lyophilization process. Therefore, in this study, effects of lyophilization on SSL were evaluated for physical characteristics changes upon rehydration of lyophilized SSL such as the particle size, efficiency of drug entrapment, turbidity and drug release. SSL containing streptozocin, a water-soluble anticancer drug as a model compound, were prepared with DSPC and DSPE-PEG 2000. The size was controlled to 100 nm by extrusion with polycarbonate membrane, and sucrose was used as a cryoprotectant for lyophilization at the 1:3 (lipid:sucrose) ratio. Upon rehydration of lyophilized SSL, the average size was in the range of $50{\sim}200\;nm$ which is adequate for longer circulation in blood, and the encapsulation efficiency was kept as its initial state. Rehydrated SSL were not adsorbed to rat plasma protein and revealed a similar drug release profile to that of fresh SSL before lyophilization. Therefore, lyophilization could be introduced efficiently to overcome aqueous instability problems of SSL.

• The Journal of Korean Physical Therapy
• /
• 제14권4호
• /
• pp.28-44
• /
• 2002

The purpose of this study is to discuss and analyze the effect of blood glucose on treadmill exercise, functional food and their combined treatment protocol on diabetic rats. These group were divided treadmill exercise group(n:12), functional food feeding group(n:12), treadmill exercise with functional food feeding group(n:12) and control group. The following results were obtained from this study. 1. The blood glucose level was showed significantly different in several group, treadmill exercise with functional food feeding group are most significantly on other group. 2. The inhibitory rate of body weight was not significantly different on each group. 3. The amount of feeding was not significantly in several group. 4. The Islets size and Connective tissue proliferation was showed significantly different except control group, treadmill exercise with functional food feeding group are more significantly than other group. These results show that treadmill exercise with functional food feeding and their several protocols can retard the setreptozotocin-induced dibetic rat.