• 제목/요약/키워드: targeting

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Nasal Stability of PEGylated Salmon Calcitonins

  • Youn, Yu-Seok;Na, Dong-Hee;Jung, Ju-Young;Park, Eun-Ji;Lee, Sang-Deuk;Lee, Kang-Choon
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.222.1-222.1
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    • 2002

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Mitochondria-targeting theranostics

  • Kang, Han Chang
    • 생체재료학회지
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    • 제22권4호
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    • pp.221-234
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    • 2018

  • Background: Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria have received substantial attention due to their significant controlling functions in cells. Main body: With the necessity of subcellular organelle-targeting drug delivery and theranostics, examples of mitochondria-targeting moieties and types of mitochondria-targeting theranostics were introduced. In addition, the current studies of mitochondria-targeting theranostic chemicals, chemical conjugates, and nanosystems were summarized. Conclusion: With the current issues of mitochondria-targeting theranostic chemicals, chemical conjugates, and nanosystems, their potentials and alternatives are discussed.

  • https://doi.org/10.1186/s40824-018-0145-7 인용 KSCI

Enhanced in vitro/in vivo Characteristics of Glucagon-like Peptide-1 by PEGylation

  • Han, H.S.;Youn, Y.S.;Oh, S.H.;Hong, S.T.;Lee, J.E.;Lee, S.O.;Lee, K.C.
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.298.2-298.2
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    • 2003

  • The insulinotropic hormone, glucagons-like peptide-1 (GLP-1), which has been proposed as a new potential therapeutics for type-II diabetes, but this is metabolized extremely rapidly by the ubiquitous enzyme, dipeptidyl peptidase IV (DPP IV), forming a metabolite, which acts as an antagonist at the GLP-1 receptor. (omitted)

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