• PNF and Movement
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• v.6 no.3
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• pp.19-28
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• 2008

Purpose : The objective of this study was to determine efficacy of sleep-dependent motor learning. Methods : This is a literature study with books and internet. We searched the PubMed, Science Direct, KISS and DBpia. Key words were Sleep-dependent, motor learning, RAM and LTP. Results : Procedural memory, like declarative memory, undergoes a slow, time-dependent period of consolidation. A process has recently been described wherein performance on some procedural task improves with the mere passage of time and has been termed "enhancement". Some studies have reported that the consolidation/enhancement of perceptual and motor skill is dependent on sleep. Specially, rapid-eye-movement(REM) sleep seems to benefit procedural aspects of memory. Conclusion : Motor learning is very important for CNS injury patients. And also distribution of practice sessions is important because REM sleep is to benefit procedural aspects of memory consolidation.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.505-510
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• 1996

Many diseases cause other diseases with strength of influences and time intervals. Prognostic and therapeutic assessments are the important part of clinical medicine as well as diagnostic assessments. In cases where a patient already has manufestations of multiple disorders (complications), progress forecasting and therapy decision by physicians without support tools are very dificult: physicians often say that "Once complications set in, the patient may die". Treating complications are difficult tasks for physicians, because they have to consider all of the complexities, possibilities and interactions between the diseases. The prediction of multiple disorders has many bundles that arise from such time-dependent interrelationships between diseases and nonlinear progress. This paper proposes a model based on time-dependent influences, which appropriately describes the progress of mulitple disorders, and gives some modificaitons for applying this model to medical domains: time-dependent influence matrix manifestation vector, therapy efficacy matrix, S-shaped curve approximation, definitions of which are provided. This research proposes an algorithm for forecasting the state of each disease on the time horizon and for evaluation of therapy alternatives with not toy example, but real patient history of multiple disorders.disorders.

• The Journal of Korean Physical Therapy
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• v.14 no.3
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• pp.297-307
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• 2002

We have isolated a sesquiterpene lactone, cumambrin A from the dried flowers of Chrysanthemum boreale Makino and reported its chemical structure. The aim of the present study was to investigate whether the exogenous administration of cumambrin A has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In vitro studies: Relaxative response induced by cumambrin A was increased with dose-dependent manner and showed maximizing response at a concentration of 5?0-4 M. Further, this relaxative response was significantly increased at a condition of endothelium present than that of endothelium denuded. in vivo studies: The normalizing effect of cumambrin A on blood pressure was also increased with time-dependent manner and then gradually recovered to normal condition at approximately 4 hrs after cumambrin A treatment.

• Journal of muscle and joint health
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• v.10 no.1
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• pp.7-18
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• 2003

This study was to investigate the effects(pain, discomfort, and range of motion) of heat therapy according to the application time among the elderly with osteoarthritis. Study participants were 27 elderly women, who were diagnosed as osteoarthritis, suffered from it for more than 6 months, and who were staying at a nursing home in Busan. The independent variable was heat therapy, which was applied for 20minutes, one time per week according to 3 timetable(before waking up, while in daily living, before going to bed) over 6 weeks. The dependent variables were pain and discomfort measured by 20 points visual analog scales, and range of extension and flexion measured by goniometery. The data were analyzed by descriptive statistics and repeated measures ANOVA. The results were as follows ; 1) There were significant differences for pain(F=9.77 p=.0001), discomfort(F=8.07 p=.001), range of extension(F=3.05 p=.05), and flexion(F=9.67 p=.0001) among heat therapy application times. 2) There were significant differences for pain(F=58.18 p=.0001), discomfort(F=63.68 p=.0001), range of extension(F=11.59 p=.001), and flexion(F=17.59 p=.0001) between before and after applying heat therapy. 3) There were not statistically significant differences for pain(F=.64 p=.531), discomfort(F=.18 p=.836), range of extension(F=1.33 p=.270), and fiexion(F=.26 p=.773) between before and after applying heat therapy according to the heat therapy application times. In conclusion, heat therapy was effective in reducing pain and discomfort, and in improving ROM for the elderly with osteoarthritis, but the effect of it was not different according to the time of application. We recommended further studies with larger sample size, longer and more repeatedly applied to investigate the effect of heat therapy according to the time of application.

• Physical Therapy Rehabilitation Science
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• v.3 no.1
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• pp.33-37
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• 2014

Objective: Low intensity pulsed ultrasound (LIPUS) has been shown to accelerate cell proliferation and tissue healing in both animal models and clinical trials. However, details of the clinical effects of LIPUS have not been well characterized. The aim of this study was to investigate the effect of LIPUS on mitogen-activated protein kinase (MAPK) activation in rat articular chondrocytes. Design: Cross-sectional study. Methods: Chondrocyte were cultured in six well cell culture plates for 72 hours at $37^{\circ}C$ with 5% $CO_2$, and then exposed to LIPUS at 1.5 MHz frequency and $30-mW/cm^2$ power. Changes in chondrocyte activities were evaluated in response to oxydative stress in dose-dependent (0 and 300 uM) and time-dependent (0-24 hr) manner. The cell viability were analyzed using MTT [3-(4.5-dimethylthiazol-2-yl)-2.5 diphenyltetrazolium bromide]. The expression of p38 MAPK was measured using western blotting. Results: Oxidative stress was induced in rat chondrocytes using hydrogen peroxide ($H_2O_2$). The cell viability was decreased in chondrocytes after the $H_2O_2$ dose and time-dependent treatment. The p38 MAPK phosphorylation occurred at a significantly increased rate after $H_2O_2$ treated (p<0.05). Expression of p38 MAPK was decreased in the p38 inhibitor groups compared with the oxidative stress-induced chondrocyte damage via the p38 MAPK signaling pathways (p<0.05). Conclusions: It could be concluded that LIPUS can inhibit oxidative stress-induced chondrocyte damage via the p38 MAPK signaling pathways.

• The Journal of Korean Physical Therapy
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• v.15 no.2
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• pp.146-156
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• 2003

Isolated rat thoracic aorta which is pharmacologically precontracted by phenylephrine induces photorelaxation when exposed to long wave length UV-light. The aim of the present study was to characterize the mechanism of UV-light induced by photorelaxation in the rat aorta. 1. UV light relaxed both endothelium-intact and -denuded rat aortic rings contracted by phenylephrine. The magnitude of relaxation on UV light was dependent on the exposure time and slightly greatly in endothelium-denuded rings than in endothelium-intact preparations. 2. L-NAME (10 nM - 100 $\mu$M) but not D-NAME completely inhibited the photorelaxation in a concentration dependent manner. 3. The UV-induced relaxation was inhibited by methylene blue (1 - 100 uM), and verapamil (100 nM), and removal of extracellular $Ca^{2+}$. In contrast, UV-light induced photorelaxation was potentiated by $N^{w}$-nitro-L-arginine (L-NNA) treatment. These results suggest that UV light-induced photorelaxation may be due to nitric oxide from exogenously administered L-arginine as well as endogenous nitric oxide donors such as amino acid and arginine derivatives

• Journal of Korean Physical Therapy Science
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• v.16 no.4
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• pp.29-37
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• 2009

Background: The purpose of this study was influence of change of electrical stimulation time on body regions affects on electrical current threshold. Methods: The present study is to examine the effect of silver spike point (SSP) electrical stimulation (1Hz), transcutaneous electrical nerve stimulation (TENS, 100Hz), and interferential current therapy (ICT, 50Hz) from the low back and scapulodorsal and knee joint regions on stimulation-induced current thresholds from the elderly (over sixty) people (male:72, female:91) in senior welfare center. Result: The low back region, but not scapulodorsal and knee joint region, significantly increased the TENS and ICT, but not SSP, electrical stimulation, significantly increased the time-dependent current thresholds in elderly patients. Conclusion: Therefore, these results, in part, suggest that the TENS and ICT were shown to be a more adaptable method of stimulation, and that needed of the development of senile specialized physical therapy and the utilization of senior leisure facilities such as senior welfare center the others.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.2
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• pp.239-245
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• 2013

In in vitro study, the anti-platelet aggregation effect of Shiitake mushroom extract was examined by measuring the collagen induced platelet aggregation and the DPPH radical scavenging. In in vitro study, anti-thrombotic effect of Shiitake mushroom extract was examined using the carotid artery thrombosis rat model. Carotid artery thrombosis rat model was made by 35% $FeCl_3$ treatment. After that, we investigate thrombus weight and blood flow. In platelet aggregation test, the extract significantly inhibited platelet aggregation in a concentration dependent manner(p<.001). Also, extract increased DPPH radical scavenging activity in a concentration dependent manner. Extract significantly inhibited thrombus weight to compare with control group. And blood passage time were shorter in the Shiitake mushroom extract supplemented groups than in control group. These results provide experimental evidence that Shiitake mushroom can be used to prevent platelet aggregation and thrombosis, then could apply the clinical diseases such as cardiovascular disease, and so on.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6161-6164
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• 2014

Background: We have reported the radiation could activate STAT3, which subsequently promotes the invasion of A549 cells. We here explored the dose- and time-response of STAT3 to radiation and the effect of radiation on upstream signaling molecules. Materials and Methods: A549 cells were irradiated with different doses of ${\gamma}$-rays. The expression of and nucleus translocation of p-STAT3 in A549 cells were detected by immunoblotting and immunofluorescence, respectively. The level of phosphorylated EGFR was also assessed by immunoblotting, and IL-6 expression was detected by real time PCR and ELISA. Results: Radiation promoted the phosphorylation of STAT3 at Y705 in a dose- and time-dependent manner and nuclear translocation. The level of phosphorylated EGFR in A549 cells increased after radiation. In additional, the mRNA and protein levels of IL-6 in A549 cells were also up regulated by radiation. Conclusions: STAT3 is activated by radiation in a dose-and time-dependent manner, probably due to radiation-induced activation of EGFR or secretion of IL-6 in A549 cells.

• Journal of the Korean Society of Physical Medicine
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• v.12 no.3
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• pp.43-47
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• 2017

PURPOSE: The purpose of this study was to identify the effects of physical therapy plus Kinesio taping (KT) on muscle tone and stiffness in patients with shoulder pain. METHODS: This study included 22 participants who were divided into the experimental group (n=11) who underwent a routine physical therapy with KT and the control group (n=11) who received the same physical therapy only. The physical therapy consisted of heat application and electrical stimulation. Heat was applied for 10 minutes and electrical stimulation was conducted for 20 minutes. Intervention was provided over a 1-week period, and frequency for muscle tone and stiffness was measured to determine changes in shoulder muscle status. The muscles were supraspinatus and deltoid. Measurements were taken before, after 1day, 3day and after 1 week to identify time-dependent effects of intervention. RESULTS: The effects of the intervention were significant in both groups, and effects were greater in the experimental group. Changes in muscle tone and stiffness were statistically significant in both groups and at varying time points (p<.05). CONCLUSION: Based on the improved muscle performance found in this study, KT is considered an effective intervention strategy for patients with shoulder pain when it is combined with conventional physical therapy.