• The Korean Journal of Applied Statistics
• /
• v.21 no.1
• /
• pp.65-80
• /
• 2008

Small scale time-course microarray experiments are those which have a small number of time points. They comprise about 80 percent of all time-course microarray experiments conducted up to 2005. Several statistical methods for the small scale time-course microarray experiments have been proposed. In this paper we applied three methods, namely, QR method, maSigPro method and STEM, to a real time-course microarray experiment which had six time points. We compared the performance of these three methods based on a simulation study and concluded that STEM outperformed, in general, in terms of power when the FDR was set to be 5%.

• Molecules and Cells
• /
• v.26 no.4
• /
• pp.338-343
• /
• 2008

An embryonic stem cell is a powerful tool for investigation of early development in vitro. The study of embryonic stem cell mediated neuronal differentiation allows for improved understanding of the mechanisms involved in embryonic neuronal development. We investigated expression profile changes using time course cDNA microarray to identify clues for the signaling network of neuronal differentiation. For the short time course microarray data, pattern analysis based on the quadratic regression method is an effective approach for identification and classification of a variety of expressed genes that have biological relevance. We studied the expression patterns, at each of 5 stages, after neuronal induction at the mRNA level of embryonic stem cells using the quadratic regression method for pattern analysis. As a result, a total of 316 genes (3.1%) including 166 (1.7%) informative genes in 8 possible expression patterns were identified by pattern analysis. Among the selected genes associated with neurological system, all three genes showing linearly increasing pattern over time, and one gene showing decreasing pattern over time, were verified by RT-PCR. Therefore, an increase in gene expression over time, in a linear pattern, may be associated with embryonic development. The genes: Tcfap2c, Ttr, Wnt3a, Btg2 and Foxk1 detected by pattern analysis, and verified by RT-PCR simultaneously, may be candidate markers associated with the development of the nervous system. Our study shows that pattern analysis, using the quadratic regression method, is very useful for investigation of time course cDNA microarray data. The pattern analysis used in this study has biological significance for the study of embryonic stem cells.

• Journal of Information Technology Services
• /
• v.20 no.6
• /
• pp.125-139
• /
• 2021

To explore college students' course satisfaction over the course of the semester during which a full-scale digital transformation was in progress due to COVID-19 pandemic, this study analyzed student survey data from a university located in the metropolitan area. To minimize the respondents' burden to answer long list of detailed questions in repetition, the study utilized a pulse survey method and students were asked to answer a brief and regular set of online questions 5 times throughout the semester. The number of survey respondents ranged from 1,640 to 4,116, with an average of more than 3,700. The main results and implications of this study are summarized as follows. First, the survey data indicated that the overall student satisfaction with online courses was above average (3.46/5). Vast majority of students have chosen pre-recorded, contents-based course over real-time, video-based course as their preferred course delivery method and this tendency remained the same throughout the semester. Second, the results of keyword network analysis of open-ended questions indicated that technical issues, increased workload (e.g., course assignments and course attendance) were main causes of online course dissatisfaction. And students suggested an unified online course platform and more interactive course design to further improve online courses in the future.

• Korean Journal of Applied Biomechanics
• /
• v.29 no.1
• /
• pp.1-8
• /
• 2019

Objective: The purpose of this study was to confirm that the cross-country ski sprint course in PyeongChang, where the 2018 Winter Olympics course was to utilize wearable devices equipped with inertial measurement unit (IMU), global positioning system (GPS) and heart rates sensor. Method: For the data collection, two national level cross-country (XC) skiers performed classic technique on the entire sprint course. We analyzed cycle characteristics, range of motion on double poling (DP) technique, average velocity, and displacement of 3 points according to the terrain. Results: The absolute cycle time gradually decreased during starting, middle and finish sections. While the length of the DP increased and the heart rates tended to increase for men skier. In addition, the results indicated that range of motion of knee joint during starting and finish section decreased more than middle section. The errors of latitude and longitude data collected through GPS were within 3 m from 3 points. Conclusion: Through the first case study in Korea, which analyzed the location and condition of XC skiers in the entire sprint course in real time, confirmed that feedback was available in the field using various wearable sensors.

• The Korean Journal of Applied Statistics
• /
• v.24 no.4
• /
• pp.623-631
• /
• 2011

A major goal of time-course microarray data analysis is the detection of groups of genes that manifest similar expression patterns over time. The corresponding numerous cluster algorithms for clustering time-course microarray data have been developed. In this study, we proposed a clustering method based on the primary pharmacokinetic parameters in the pharmacokinetics study for assessment of pharmaceutical equivalents between two drug products. A real data and a simulation data was used to demonstrate the usefulness of the proposed method.

• Smart Media Journal
• /
• v.12 no.5
• /
• pp.88-101
• /
• 2023

As the definition and role of design changes over time with the times and society, design education needs to update teaching methods to match it. The course design in this study began with an optimisation of the learning model based on previous research and analysis, followed by in-depth interviews, the application of the interview results to the final curriculum design, and finally a questionnaire to verify the positive effects of this teaching model. This teaching model has been applied to teach a pilot class in a university of applied sciences in China. The main characteristics of the course design are Project-Based Learning (PJBL) oriented, team cooperation centric, and an educational model developed based on peer assessment. In every stage of the UI design course, realistic project simulations are adopted, enhancing students' abilities through practical experience, teamwork, and peer assessment. The innovation lies in validating the effectiveness and advantages of this model at every stage of the UI design course, innovating existing teaching methods, optimizing learning models, and combining practice with evaluation. This research found that a project-oriented team course design based on PJBL has a high degree of effectiveness and relevance in each stage of the UI design course, significantly improving students' overall competence. It is expected that the results of this study can be applied in various ways to the course design of the courses that similar to design majors.

• Biomedical Science Letters
• /
• v.11 no.2
• /
• pp.221-225
• /
• 2005

To investigate the spectroscopic findings of embolized lesions induced with a fat-emulsion technique with magnetic resonance images (MRI). A fat emulsion was made with 0.1 ml of triolein and 20 ml of normal saline. In 12 cats, the internal carotid artery was infused with the fat emulsion. Contrast-enhanced T1-weighted MRI and multivoxel spectroscopy were obtained at 1 hour, 1 and 4 days, and 1 week after embolization. NAA (N-acetylaspartate), Cr (creatine) and Cho (choline) were evaluated on the spectroscopy. Statitistical analysis wsperformed at the embolized and contralateral normal hemisphere in the integral and amplitude of NAA, Cr and Nho in time course. Also NAA/Cr and Cho/Cr were compared in both hemisphere and in time course. The emboli zed lesions showed contrast enhance ments on Gd-enhanced Tl-weighted i~ages at 1 hour. This contrast enhancement was decreased at day 1, and id not appear agter day 4. In spectroscopy, the embolized hemisphere showed no statistical difference to the normal contralateral side at 1 hour and in time course. NAA/Cr and Cho/Cr were not significantly different in both hemispheres at 1 hour and in time course. Cerebral-fat embolism induced by a triolein emulsion in cats revealed no statistical difference on MR spectroscopy. Triolein-emulsion can be used in the study of blood-brain barrier.

• The Journal of Churna Manual Medicine for Spine and Nerves
• /
• v.5 no.1
• /
• pp.157-168
• /
• 2010

Objectives: The aim of this study was to investigate the curriculum of Chuna manual medicine (CMM)-related subjects in oriental medicine college and to let CMM have opportunities to develope current curriculum and basic circumstance for CMM. Methods: Questionnaire was obtained from 11 oriental medicine college and 1 school of Korean medicine, Pusan National University, bye-mail. If there was any insufficient information from response, we asked more information by direct call. Results and Conclusions: The findings from our study can be summarized as follows: 1. There are three CMM-related subjects, CMM, Oriental Rehabilitation Medicine (ORM) and Neuromusculoskeletology(NMS). All curriculums of 8 colleges belonged to classification I have CMM and DRM courses. Curriculums of 4 colleges belonged to classification II, have ORM or NMS course without CMM course. 2. 10 colleges of 11 ones which have ORM course, have major compulsory courses, 1 college has a major optional course. 5 colleges of 8 ones which have CMM course, have major compulsory courses, 3 colleges have major optional courses. 2 colleges have only part-time lecturers for CMM course, other 2 college have cooperation of specialized professors and part-time lecturers, another 8 colleges have only specialized professors. 3. Most CMM-related subjects is teached at 3 or 4 grade of medical course. The units taken for CMM-related subjects is minimum 4 units to maximum 8 units in total about 160 units. 4. Total class hour for CMM-related subjects is minimum 120 hours to maximum 225 hours, and practice hours is about minimum 30 hours to maximum 75 hours. 5. The systematic regulation and financial support is needed for patients to get the best CMM treatment, because the present curriculum of CMM is insufficient for carrying out the best manual therapy for patients.

• The Journal of the Convergence on Culture Technology
• /
• v.6 no.4
• /
• pp.693-701
• /
• 2020

In this paper, SQL statements are analyzed to improve database performance in the current course registration system. The performance of the current database was measured through the execution plan of the SQL statements used in the transactions related to the course registration. Through the SQL analysis, the complemented SQL statements confirmed the improved performance. Overall, the performance of the course registration database system was improved through the analysis of the execution plan, and some improvement methods of the course registration SQL were shown as test results. The improved method is to reorganize the tables and index tables related to the course registration through database tuning, and utilize the SQL function to implement an optimized system that has evolved into a course database system with improved performance. The enrollment system re-adjusted by the proposed method showed excellent results in terms of performance compared to the previous enrollment system, and the integrated performance test result reduced the response time by 1.8 to 18 times.

• Journal of Practical Agriculture & Fisheries Research
• /
• v.10 no.1
• /
• pp.137-151
• /
• 2008

This research was conducted to suggest a policy plan for intensive major course in recurrent education system of KNAC. A survey was answered by students, graduates, field professors and (full-time) professors. The results are summarized as follows; 1. In the item of educational operation system, there were some differences in preference among 4 examinee groups. Students preferred 'semester system', graduates and field professors did 'once per week system', and professors 'cyber+centralized training system'. 2. As entering time, students and graduates preferred 'immediately after graduation'. However, field and full-time professors preferred '1 to 3 years after graduation' that became reality. 3. As board and lodging, all examinee groups wanted 'dormitory in college'. Students and graduates were open to pay educational expenses as a level of national colleges. 4. As a curriculum, the most preferred subject by all groups was 'major field technique', which was followed by 'marketing/sale' and 'farm management' in the order of preference.