• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.6 no.1
• /
• pp.27-38
• /
• 2020

Alzheimer's disease (AD) is one of the challenging conditions that have no cure, yet early diagnosis can help to control the disease. PET imaging of tau has several advantages, such as being a noninvasive, safe diagnostic technique that correlates directly with the disease progression. Many tau tracers have been reported to date; however, the chemical scaffolds of them fall in a narrow chemical window, and none was approved yet as none is entirely selective and sensitive to tau. These problems are being solved as new tracers emerge constantly. In this report, the first-generation tau tracers such as [¹¹C]PBB3, 2-arylquinoline (THK) series, [¹⁸F]T808, and [¹⁸F]AV-1451 ([¹⁸F]T807) are reviewed from an organic and radiochemistry perspective; thus the most effective chemical approach to synthesize these tracers is discussed. This would help to design novel tracers which can meet the challenges faced by the current tracers.

• Journal of the Korean earth science society
• /
• v.42 no.4
• /
• pp.383-389
• /
• 2021

Several studies investigating the behavior and environmental distribution of rare earth elements (REEs) have been reviewed to determine the geochemical processes that may affect their concentrations and fractionation patterns in groundwater and whether these elements can be used as tracers for groundwater-rock interactions and groundwater flow paths in small catchments. Inductively coupled plasma-mass spectrometry (ICP-MS), equipped with an ultrasonic nebulizer and active-film multiplier detector, is routinely used as an analytical technique to measure REEs in groundwater, facilitating the analysis of dissolved REE geochemistry. This review focuses on the distribution of REEs in groundwater and their application as tracers for groundwater geochemistry. Our review of existing literature suggests that REEs in ice cores can be used as effective tracers for atmospheric particles, aiding the identification of source regions.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.9 no.4
• /
• pp.52-59
• /
• 2006

This study was conducted to find end-members and tracers which are effective to be applied in the End Member Mixing Analysis (EMMA) model for runoff separation at the Gwangneung coniferous forest catchment (13.6ha), Gyeonggido, Korea. We monitored three successive rainfall events during two weeks from June 26, 2005 to July 10, 2005, and analysed chemical properties of rainfall, throughfall, stemflow, groundwater and soil water considered as main components of storm runoff. The followings are the results of analyses of each component and tracer. Groundwater, soil water and rainfall (or throughfall) were dominant runoff components. Rainfall and groundwater were selected as main components for the two components-one tracer mixing model, and groundwater, soilwater and throughfall were selected as main components for the three components-two tracers mixing model. Tracers were selected from anion ($Cl^-$ and ${SO_4}^{2-}$), cation ($Na^+$, $K^+$, $Mg^{2+}$, and $Ca^{2+}$) and Acid Neutralizing Capacity (ANC) in event 1, 2, and 3. $Na^+$, $Ca^{2+}$ and ANC were selected in the two components-one tracer mixing model and ${SO_4}^{2-}-K^+$, ${SO_4}^{2-}-Na^+$, ${SO_4}^{2-}-Ca^{2+}$, ${SO_4}^{2-}$-ANC, and $Ca^{2+}$-ANC were selected in the three components-two tracers mixing model. Selected main runoff components and tracers can provide basic information to determine the contribution rate of each runoff component and identify the runoff process in a forest watershed.

• Brain Tumor Research and Treatment
• /
• v.6 no.2
• /
• pp.47-53
• /
• 2018

Brain tumors represent a diverse spectrum of histology, biology, prognosis, and treatment options. Although MRI remains the gold standard for morphological tumor characterization, positron emission tomography (PET) can play a critical role in evaluating disease status. This article focuses on the use of PET with radiolabeled glucose and amino acid analogs to aid in the diagnosis of tumors and differentiate between recurrent tumors and radiation necrosis. The most widely used tracer is $^{18}F$-fluorodeoxyglucose (FDG). Although the intensity of FDG uptake is clearly associated with tumor grade, the exact role of FDG PET imaging remains debatable. Additionally, high uptake of FDG in normal grey matter limits its use in some low-grade tumors that may not be visualized. Because of their potential to overcome the limitation of FDG PET of brain tumors, $^{11}C$-methionine and $^{18}F$-3,4-dihydroxyphenylalanine (FDOPA) have been proposed. Low accumulation of amino acid tracers in normal brains allows the detection of low-grade gliomas and facilitates more precise tumor delineation. These amino acid tracers have higher sensitivity and specificity for detecting brain tumors and differentiating recurrent tumors from post-therapeutic changes. FDG and amino acid tracers may be complementary, and both may be required for assessment of an individual patient. Additional tracers for brain tumor imaging are currently under development. Combinations of different tracers might provide more in-depth information about tumor characteristics, and current limitations may thus be overcome in the near future. PET with various tracers including FDG, $^{11}C$-methionine, and FDOPA has improved the management of patients with brain tumors. To evaluate the exact value of PET, however, additional prospective large sample studies are needed.

• Journal of Soil and Groundwater Environment
• /
• v.12 no.2
• /
• pp.47-54
• /
• 2007

The partitioning tracer method has been studied as an alternative method for detecting and characterizing the distribution of nonaqueous phase liquids (NAPLs) contaminants in subsurface. The reliability of the partitioning tracer method depends on accurate measurements of partition coefficients of the partitioning tracers between water and NAPLs. In this study, partition coefficients of several alcohol tracers between water and benzene, toluene, ethylbenzene, xylene, and BTEX mixtures are estimated using the modified approach of equivalent alkane carbon number (EACN). Agreements between the measured and estimated partition coefficients were generally observed in experiments. Based on these results, it is confirmed that the partition coefficients of tracers are readily obtained without experiments if the EACN values for the tracers and LNAPLs are known.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.23 no.9
• /
• pp.1163-1171
• /
• 1999

Superdiffusive transport motions of passive scalars are numerically considered for various advection velocity fields. Calculated exponents ${\alpha}$ in the superdiffusion-defining relation ${\sigma}^2(t){\sim}t^{\alpha}$ for model flow fields agree to the theoretically predicted values. Simulation results show that the superdiffusion takes place as the tracers' motion become less random, compared to their motion at the pure molecular diffusion. Whether the flow field is random or not, degrees of superdiffusion are directly related to the velocity autocorrelation functions along the tracers Lagrangian trajectories that characterize degrees of randomness of the tracers' motion.

• Journal of Environmental Health Sciences
• /
• v.29 no.3
• /
• pp.43-49
• /
• 2003

ETS concentrations in the PC game rooms and factors affecting ETS concentrations were measured. Nicotine, 3-EP, respirable dust and UVPM were used as tracers for ETS. ETS concentrations are 2-3 times higher than those of other results. The concentration of ETS at the commercial district was higher than that of the residential district. The correlations between these tracers and SD/ ACH, a factor affecting to ETS concentration, were calculated. The correlation between 3-ethenylpyridine among tracers and SD/ACH was highest. The correlation between respirable dust and SD/ ACH was lowest. It was difficult to recommend respirable dust as a tracer of ETS.

• Nuclear Engineering and Technology
• /
• v.44 no.1
• /
• pp.79-88
• /
• 2012

Migration tests were performed with conservative tracers in a fractured zone that had a single fracture of about 2.5 m distance at the KURT. To interpret the migration of the tracers in the fractured rock, a solute transport model was developed. A two dimensional variable aperture channel model was adopted to describe the fractured path and hydrology, and a particle tracking method was used for solute transport. The simulation tried not only to develop a migration model of solutes for open flow environments but also to produce ideas for a better understanding of solute behaviours in indefinable fracture zones by comparing them to experimental results. The results of our simulations and experiments are described as elution and breakthrough curves, and are quantified by momentum analysis. The main retardation mechanism of nonsorbing tracers, including matrixdiffusion, was investigated.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
• /
• 2006.04a
• /
• pp.115-118
• /
• 2006

The partitioning tracer method has been studied as an alternative method for characterizing aquifers contaminated by nonaqueous phase liquids (NAPLs). Accurate partition coefficients of tracers partitioning between NAPL and water are needed to improve the reliability of the partitioning tracer method. In this research, partition coefficients of alcohol tracers partitioning between benzene, toluene, ethylbenzene, and xylenes (BTEX) compounds and water are estimated from using the approach of equivalent alkane carbon number (EACN). General agreement was observed in between the measured and estimated partition coefficients. Based on these results we can verify that the EACN approach is suitable for estimating the partition coefficient.

• Journal of Soil and Groundwater Environment
• /
• v.12 no.4
• /
• pp.86-93
• /
• 2007

In recent tests using tracer have been frequently conducted by fluorescent tracers. In this study, granular activated charcoal (GAC) as a detector for the fluorescent tracers (rhodamine WT and uranine) was investigated through laboratory and field tests. In the laboratory tests, tracer concentrations of rhodamine WT and uranine determined by the GAC were slightly different from those of standard solutions but they were excellent in linearity. Results show that GAC is excellent as tracer detector when concentration of the fluorescent tracers is greater than 10 & micro; g/L whileas no obvious differences in mixed solutions of the two tracers due to interferences. Compared to conventional methods of water sampling, field results shows a high potential of GAC as a tracer in the field. Our results also show that wet analysis is better for the lower concentrations of tracers whileas dry analysis is good for high concentrations of tracers. This study demonstrates that fluorescent tracer detection using the GAC is very useful and economical for a hydraulic connection between target areas and very longer period of the tracer test.