• Title/Summary/Keyword: transaminases

Search Result 48, Processing Time 0.03 seconds

Hepatoprotective Activities of Biologically Active Agents from Crude Drugs(I) -Hepatoprotective Activities of Traditional Korean Herbal Prescriptions- (식물성생리활성물질(植物性生理活性物質)의 간보호작용(肝保護作用)(I) -한약처방(韓藥處方)의 간보호작용(肝保護作用)-)

  • Kim, Chang-Johng;Cho, Seung-Kil;Choi, Chung-Sik;Choi, Yun-Suk
    • Korean Journal of Pharmacognosy
    • /
    • v.21 no.3
    • /
    • pp.223-234
    • /
    • 1990
  • Hepatoprotective activities of 26 traditional Korean herbal prescriptions described in Donghibogam were evaluated in vivo and in vitro screening system. Twenty one prescriptions appeared to be active. Six prescriptions among them showed highly significant hepatoprotective activities; Shihogyegy-Tang(柴胡桂枝湯), Soshiho-Tang(小柴胡湯), Shiho plus Younggolmoryo-Tang(柴胡加龍骨牡蠣湯), Yinjinho-Tang(茵蔯蒿湯), Yinsam-Tang(人蔘湯) and Shashim-Tang(瀉心湯). Shihogyegy-Tang was most active. They reduced the release of transaminases from dissociated hepatocytes by thioacetamide, and serum transaminases and alkaline phosphatase activities of rat with carbontetrachloride-induced hepatitis. They inhibited significantly lipid peroxidation and cellular fatty change of liver by carbontetrachloride.

  • PDF

HEPATOTOXICITY OF PHOTOTOXIC DRUGS USED IN SYSTEMIC PHOTOCHEMOTHERAPY

  • Hann, Seung-Kyung;Choi, Gwang-Seong;Park, Yoon-Kee
    • Journal of Photoscience
    • /
    • v.3 no.1
    • /
    • pp.29-31
    • /
    • 1996
  • Psoralens are metabolized in the liver and thus can produce liver damage in laboratory animals when given in excessive doses. However, in humans, reports of the effects of psoralens on liver functions during photochemotherapy have been contradictory. We studied 311 patients t o observe the effects of various phototoxic drugs: 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), 4,5,8-trimethylpsoralen (TMP)-on liver function during photochemotherapy. Of the 311 patients, only seven had transient elevations of transaminases. Incidence of hepatotoxicity of 8-MOP, TMP and 5-MOP showed 0.6%, 6% and 3%, respectively. Although the effects of psoralens on liver functions during photochemotherapy have been contradictory in humans and there have been few cases showing transient elevated values of liver transaminases during photochemotherapy, it is advisable to obtain serial liver function tests before and during photochemotherapy.

  • PDF

EFFECT OF LOW DEGRADABLE DIETARY PROTEINS ON HEPATIC METABOLISM OF EARLY LACTATING BUFFALOES

  • Sikka, P.;Sengar, S.S.;Mudgal, V.D.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.5 no.4
    • /
    • pp.643-646
    • /
    • 1992
  • Role of low degradable protein in milk production of early lactating Murrah buffaloes has been studied in relation to energy status of test animals. Replacement of conventional concentrate mixture with low degradable cotton seed cake resulted in appreciable changes in circulatory transaminases and phosphatase levels. The enzymes viz. glutamate oxaloacetate and glutamate pyruvate transaminase and alkaline phosphatases increased with feeding of said cake indicating stress on hepatic tissue. Animals seemed to overcome stress by feeding enhanced levels of same protein along with improved feed intake, body weight and milk production.

The Challenges of Diagnosing and Following Wilson Disease in the Presence of Proteinuria

  • Khan, Soofia;Schilsky, Michael;Silber, Gary;Morgenstern, Bruce;Miloh, Tamir
    • Pediatric Gastroenterology, Hepatology & Nutrition
    • /
    • v.19 no.2
    • /
    • pp.139-142
    • /
    • 2016
  • The coexistence of Wilson disease with Alport syndrome has not previously been reported. The diagnosis of Wilson disease and its ongoing monitoring is challenging when associated with an underlying renal disease such as Alport syndrome. Proteinuria can lead to low ceruloplasmin since it is among serum proteins inappropriately filtered by the damaged glomerulus, and can also lead to increased urinary loss of heavy metals such as zinc and copper. Elevated transaminases may be attributed to dyslipidemia or drug induced hepatotoxicity. The accurate diagnosis of Wilson disease is essential for targeted therapy and improved prognosis. We describe a patient with a diagnosis of Alport syndrome who has had chronic elevation of transaminases eventually diagnosed with Wilson disease based on liver histology and genetics.

Abdominal Subcutaneous Fat Thickness Measured by Ultrasonography Correlates with Hyperlipidemia and Steatohepatitis in Obese Children

  • Lee, Sung Hyun;Kim, Dongwan;Baek, Min Young;Tchah, Hann;Kim, Yeon Sun;Ryoo, Eell;Kim, Yun Mi
    • Pediatric Gastroenterology, Hepatology & Nutrition
    • /
    • v.18 no.2
    • /
    • pp.108-114
    • /
    • 2015
  • Purpose: The aim of this study is to evaluate the relationship between abdominal subcutaneous fat thickness measured by ultrasonography (US) and serum lipid profile and liver transaminases in obese children. Methods: One hundred and sixty-six children diagnosed with obesity from May 2001 to December 2013 were included in this study. Data on serum lipid profile and liver transaminases were collected from clinical records. Abdominal subcutaneous fat thickness and grade of hepatic steatosis were evaluated by US. Results: Of the 166 children, 107 were diagnosed with hepatic steatosis by US, 46 with grade I, 56 with grade II, and five children with grade III. According to the grade of hepatic steasosis, the average values of midline abdominal subcutaneous fat thickness and right flank abdominal subcutaneous fat thickness measured $2.9{\pm}0.8cm$ and $1.9{\pm}0.7cm$ in the normal group, $3.3{\pm}0.8cm$ and $2.0{\pm}0.7cm$ in grade I, $3.8{\pm}0.8cm$ and $2.3{\pm}0.8cm$ in grade II, and $4.1{\pm}0.8cm$ and $2.8{\pm}1.4cm$ in grade III, respectively. Abdominal subcutaneous fat thickness correlated with grade of hepatic steatosis (p<0.01). In addition, abdominal subcutaneous fat thickness correlated with concentration of serum lipids and liver transaminases in the age group of 12-14 years (p<0.01). Conclusion: Abdominal subcutaneous fat thickness measured by US can be used as a reliable predictor of possible hyperlipidemia and steatohepatitis in children, especially during the adolescent stage.

Characterization and evaluation of liver fibrosis grade in patients with chronic hepatitis B virus infection and normal transaminases

  • Cristina, San Juan Lopez;Marta, Casado Martin;Mercedes, Gonzalez Sanchez;Almudena, Porcel Martin;Alvaro, Hernandez Martinez;Luis, Vega Saenz Jose;Tesifon, Parron Carreno
    • Clinical and Molecular Hepatology
    • /
    • v.24 no.4
    • /
    • pp.384-391
    • /
    • 2018
  • Backgrounds/Aims: The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases. The study also aimed to evaluate liver damage by measuring the liver fibrosis (LF) grade and to identify possible factors associated with the presence of fibrosis. Methods: A retrospective observational study was conducted in patients with chronic HBV infection and classified as inactive carriers or immune-tolerant. Epidemiological variables of age, sex, immigrant, alcohol consumption, and body mass index (BMI), as well as virological variables (HBV DNA) and transaminase level were collected throughout the follow-up. The LF grade was evaluated by transient elastography. The cutoff value for significant fibrosis (SF) was liver stiffness ${\geq}7.9kPa$. Results: A total of 214 patients were included in the analysis, and 62% of them had a BMI ${\geq}25kg/m^2$. During follow-up, 4% of patients showed transaminase elevation (<1.5 times normal). Most patients had a viral DNA level <2,000 IU/mL (83%). Data on LF were available in 160 patients; of these, 14% had SF, 9% F3, and 6% F4. The variables associated with the presence of SF were transaminase alteration during follow-up, as 23% of patients with SF had elevated transaminases versus 3% of patients without SF (P<0.005), and BMI, as the vast majority of patients with SF (88%) had a BMI ${\geq}25kg/m^2$ versus 56% of patients without SF (P<0.05). Conclusions: In patients with chronic HBV infection and normal transaminases, liver damage does not seem to be related to DNA levels, alcohol consumption, or immigrant status. SF seems to be associated with transaminase alteration during follow-up and elevated BMI. It is therefore recommended to measure LF grade with validated non-invasive methods in such patients.

Tracing some enzymatic activities in three virulent pathogenic erwiniae

  • Saleh, Youssry E.
    • Archives of Pharmacal Research
    • /
    • v.13 no.1
    • /
    • pp.105-107
    • /
    • 1990
  • The absence, in the biomass, of glutamic-oxalacetic and glutamic-pyruvic transaminases and the prevalance of gamma-glutamic transpeptidase were taken as basic criteria to differentiate between Erwinia carotovora var. carorovora from E. carotovora var, citrullis and E. toxica. For further identification, detection of cholesterol in the biomass confirmed the toxica species whereas the absence of glucose confirmed the citrullis variety.

  • PDF

EFFECT OF DIETARY GINSENG ON THE ACTIVITIES OF SERUM GLUTAMIC-PYRUVIC AND GLUTAMIC-OXALOACETIC TRANSAMINASES (식이성(食餌性) 인삼(人蔘)이 혈청(血淸) GOT 및 GPT 활성(活性)에 미치는 영향(影響))

  • Kim, Hong-Ki
    • The Journal of Internal Korean Medicine
    • /
    • v.1 no.1
    • /
    • pp.85-91
    • /
    • 1976
  • A chronical intake of Substantial amount of alcohol would disrupt anormal function of liver if not develop liver diseases in relatively short period. In order to out whether ginseng or ginseng plus high protein diet have any protective effects on the liver of chronical alcoholist from developing malfunction enzymatic activities of both glutamic-pyruvic and glutamic-oxaloacetic transaminases were measured on serum of rats maintained with basal low protein diet, basal diet plus 1 percent ginseng and high protein (40%) plus 1 percent ginseng and administered intraperitoneally with a Constant amount of ethanol either periodically or chronically. It was found that, unlike human subject GOT content was exceedingly high and significant difference was found either among treatment or among sexes thus indicating that either ginseng intake or high protein diet plus ginseng has a protective effect on the liver function of ethanol treated rats. From these results, it was suggested that the dietary ginseng might, have a protective effect on the alcohol hepatic disturbance. As one of probable mechanisms for the characteristic pharmacological activity, it was considered that a secondary action of the saponin of the dietary ginseng would result in the anti-inflammatory through the stimulation of de nove synthesis of certain functional proteins in hepatic organs.

  • PDF

Inhibitory effects of the Juglans sinensis Walnut Ethanol Extract on Carbon Tetrachloride-induced hepatic fibrosis in Rats (호두인 에탄올 추출물의 사고화탄소 유도 간섬유화 억제 효과)

  • Jang Seong Il;Lim Chang Kyung;Ryu Jin Duk;Kim Hui Soo;Yun Yong Gab
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.17 no.5
    • /
    • pp.1264-1269
    • /
    • 2003
  • The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.

Protective Effects of Some Phytobased Polysaccharides on the Acute Hepatic Damages of ICR-Mice Induced by the Administration of Carbon Tetrachloride and D-Galactosamine (수종 식물성 다당류의 사염화탄소 및 D-Galactosamine 유발 급성 간손상 보호작용)

  • 문창규;안미영;정진호
    • YAKHAK HOEJI
    • /
    • v.29 no.1
    • /
    • pp.43-49
    • /
    • 1985
  • Polysaccharides obtained from Sappan Lignum, Mori Radicis Cortex and Olibanum were examined for their liver protective effects against carbon tetrachloride-and D-galactosamine intoxication in ICR-mice. Hexobarbital sleeping time and serum transaminases (S-GOT and S-GPT) were measured as parameters for the evaluation of liver protective effects. All polysaccharides tested in this experiment showed remarkable positive effects on the prevention of hepatic intoxication with carbon tetrachloride-and D-galactosamine. Much better liver protective effects of polysaccharides were observed in D-galactosamine-liver injuries than in carbon tetrachloride-injuries.

  • PDF