• 한국음향학회지
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• 제36권3호
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• pp.172-178
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• 2017

초음파는 세포사멸을 포함하여 의학 및 생물학분야에 널리 응용되고 있으나 그 정확한 기작에 대해선 논쟁의 여지가 있다. 본 연구에서는 40 kH 초음파 조사시스템을 단세포 효모에 적합하게 개발하고 세포사멸 유도시 40 kH 초음파의 생물학적 현상을 살펴보았다. 아이오딘화 칼륨 선량 측정법을 이용하여 1.5 ml 실험튜브에 40 kH 초음파 조사 시스템의 최적 조건을 맞추어 세포사멸을 시간 의존적 방식으로 연구하였고 초음파 조사과정동안 온열효과와는 별개로 세포 사멸이 관찰되었다. 40 kH 초음파와 과산화수소의 동시 처리는 세포사멸에 상조적인 효과가 관찰되어 활성산소가 40 kH 초음파사멸에 관련이 있었다. 그러나 활성산소 저해제, NAC(N-acetyl-Lcysteine)는 초음파에 의한 세포사멸에 약한 영향만을 미쳤고 다른 세포사멸, 괴사억제제[글리실리진(glycyrrhizin) 또는 zVAD-fmk] 역시도 세포사멸을 완전히 억제하진 못하였다. 본 연구를 통하여 40 kH 초음파에 의한 세포사멸에는 온열효과나 활성산소만으로 사멸이 유도되지는 않는 것으로 보인다.

• 대한의용생체공학회:의공학회지
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• 제33권1호
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• pp.32-38
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• 2012

Recently, several ultrasound imaging techniques for tissue characterization have been developed. Among them, ultrasound elastography is regarded as the most promising modality and has been rapidly developed. One of ultrasound elastography techniques is shear modulus imaging. Normal and cancerous tissues show big difference of shear moduli and they have good image contrast. However shear wave elastography requires more complicated hardware and more computations for image reconstruction algorithm. Therefore new efficient techniques are being developed. In this paper, we have developed a very flexible ultrasound system for elastography experiments. The developed system has capabilities to acquire ultrasound RF data of all channels and generate arbitrary ultrasound pulse sequences. It has a huge amount of memories for RF data acquisition and a simple and flexible pulse generator. We have verified the performance of the system showing conventional B-mode images and preliminary results of elastography. The developed system will be used to verify our own reconstruction algorithm and to develop more efficient elastography techniques.

• 대한물리의학회지
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• 제6권3호
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• pp.303-310
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• 2011

Purpose : This study examined the feedback effect of real-time ultrasound imaging on the thickness of transversus abdominis(TrA), internal abdominal oblique(IO) and external abdominal oblique(EO) during abdominal hollowing exercise(AHE) in crook lying. Methods : We performed this study on 30 healthy men who voluntarily consented to participate in this study after listening to its purpose and method. All subject were divided into an experimental group(n=15) with using the real-time ultrasound imaging feedback(RUIF) and a control group(n=15) without the RUIF The thickness changes between rest and AHE were compared between the two groups in crook lying. Results : The difference in TrA and EO thickness changes between the groups were significant in crook lying (p<0.05). Conclusion : The group with using real-time ultrasound imaging feedback showed a higher increase in the thickness of TrA than the other group without real-time ultrasound imaging feedback. And the thickness of EO in the group with using real-time ultrasound imaging feedback decreased than the other group without real-time ultrasound imaging feedback. If the muscle thickness can be regarded as an indicator of muscle activity, RUIF will be helpful for inducing the independent activity of TrA by reducing the activities of abdominal muscles such as EO.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.493-497
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• 2012

This study was conducted to retrospectively evaluate the pattern of contrast enhancement with SonoVue on gray-scale ultrasonography of hepatic angiomyolipoma (HAML). Imaging features of 33 pathologically proven HAML lesions in 33 patients who underwent baseline ultrasound and contrast-enhanced ultrasonography (CEUS) were assessed retrospectively. All lesions were enhanced in the arterial phase and showed whole-tumor filling in. Thirty-two of 33 (97%) lesions showed early positive enhancement in the arterial phase. Twenty-three of these exhibited isoechoic or hyperechoic features in the portal phase. HAML demonstrate characteristic manifestations with SonoVue-enhanced real-time gray-scale ultrasonography.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권2호
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• pp.103-110
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• 2001

This study was performed to observe the effect of ultrasound(1.0MHz, $0.75W/cm^2\;and\;1.0W/cm^2$) irradiation on cultured MC3T3-E1 cell, osteoblastic like cell with respect to the proliferation, protein synthesis, and alkaline phosphatase activity of the cells. The results were as follows: 1. The proliferation of MC3T3-E1 cells was increased on ultrasound irradiated group compared with control group. 2. The protein synthesis was not apparently increased on ultrasound irradiated group compared with control group. 3. The alkaline phosphatase activity level was not apparently increased on ultrasound irradiated group compared with control group. From the above results and other literatures, we could suggest that the ultrasound with the appropriate intensity and frequency may have important roles in stimulation of cell proliferation. Therefore the ultrasound may be used in the acceleration of the bone regeneration and bone fracture healing.

• The Journal of Korean Physical Therapy
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• 제14권1호
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• pp.55-62
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• 2002

The purpose of this study was to determine the effects of the ultrasound on treatment of chronic sinusitis. 24 persons of men and women with chronic sinusitis divided into three groups of each 8 persons randomly and when were they were treated with the medication, the ultrasound(1MHz continuous wave, 1W/$cm^2$ intensity, three times per a week and once of three minutes circular stroke method) and the medication+ultrasound for 2, 4, 6 and 8 weeks. The results of this study were ad follows. 1. There was not statistical significant differences between the effects of treatment until two weeks(P>.05). 2. There was statistical difference between the effects of treatment after 4 weeks, 6 weeks and 8 weeks(P<.05). There was statistical significant difference between the group with ultrasound treatment and the group with ultrasound+medication treatment and there was statistical significant difference between the group with medication treatment and the group with ultrasound+medication treatment but there was not statistical significant between the group with ultrasound treatment and the group with medication treatment. 3. After 4 weeks, the highest effect for chronic sinusitis was group

• 대한의용생체공학회:의공학회지
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• 제36권5호
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• pp.162-168
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• 2015

In this study, we suggested the performance and safety testing guideline for low intensity pulsed ultrasound (LIPUS) represented by the ultrasound fracture treatment device and cartilage treatment device and low intensity focused ultrasound (LIFU) represented by ultrasonic face lifting device. For these study, the international standards and management regulations of Korea, Japan and United State were analyzed. And the usefulness and applicability were evaluated by testing with commercial equipment and reflecting the views of the industry and experts. As a result of this study, the safety and performance test guidelines for low intensity therapeutic ultrasound device were proposed by presenting the 10 items for LIPUS and 12 items for LIFU. The suggested guidelines are considered a high utilization in the domestic testing and approval authorities. And they are also thought to be useful to new technology development.

• 대한정형외과 초음파학회지
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• 제6권1호
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• pp.38-44
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• 2013

근골격계 영역에서 초음파는 저류된 액체의 흡인, steroid 등의 국소 주사 및 조직의 생검 등을 위해서 주사 바늘의 정확한 위치를 찾는데 이용될 수 있다. 초음파 유도한 중재술은 실시간 시술이 가능하며, 상대적으로 비용이 저렴하고, 추가적인 방사선 노출이 없이 병변 부위의 여러 이미지를 얻을 수 있는 등의 장점으로 인해 최근 널리 사용되고 있으나 검사자의 숙련도 및 해부학적 지식 등에 따라 활용도가 달라질 수 있으며 드물지만 심각한 합병증이 보고되기도 한다. 이에 저자들은 정형외과 영역에서 초음파를 이용한 중재술의 기본적인 시술 요령과 지켜야 할 원칙 및 주의점 등에 대해 기술하고자 한다.

• 대한물리치료과학회지
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• 제10권1호
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• pp.170-179
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• 2003

This study was performed that how phonophoresis using ultrasound for piroxicam affects transdermal permeation and anti-inflammative effects. Transdermal permeation study conducted by using hairless mouse had two categories: control group and ultrasound group. Transdermal permeation was observed according to duty cycle and intensity. Anti-inflammatory effects were determined using in Sprague-Dawley rat. The subjects were divided into three groups of six SD rat each 24 hour, 48 hour, 72 hour. The results of this study were as follows: 1. Transdermal permeation of piroxicam was measured according to ultrasound duty cycle. This research demonstrates that ultrasound group retains more transdermal permeation than control group, and that pulsed ultrasound group holds a little more transdermal permeation than continuous ultrasound group. 2. The transdermal permeation of piroxicam is closely related with ultrasound intensity. Effect of each group of transdermal permeation was significant rises in proportion to ultrasound intensity. 3. By observing inflammation of the tissue caused by trauma, phonophoresis group showed more significant of anti-inflammatory effect. The conclusion of phonophoresis was found to improve significantly the transdermal permeation and the anti-inflammatory effect.

• 대한정형외과 초음파학회지
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• 제6권2호
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• pp.81-93
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• 2013

본 종설에서는 요추부 중재술에 있어서 초음파라는 장비가 영상 장치로서 얼마나 유용한가에 대해 기술하였다. 우선 요천추부의 표면 해부학과 초음파 해부학에 대하여 기술하였는데, 이는 초음파 유도하 중재술에서 영상의 판독과 술기의 수행에 있어 해부학의 자세한 이해가 반드시 필요하기 때문이다. 방사선 투시하에 척추 중재술을 하는 것이 보편화 되어 있지만 방사선을 피폭해야 하는 문제가 늘 존재한다. 초음파는 방사선이 없고 간편하며 높은 정확도로 실시간 영상을 제공하는 장점들이 있으며 어떠한 임상 환경적 조건에서도 시행할 수 있다. 초음파 유도하 요추부 중재술은 방사선 투시기나 컴퓨터 단층촬영 유도로 시행하였던 기존의 방식을 대신할 수 있으며 방사선 피폭 없이 안전하게 시행할 수 있는 방법이다.