Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)
- 1993.09a
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- Pages.84-93
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- 1993
EFFECTS OF PANAX GINSENG SAPONINS ON CHEMICAL MEDIATOR RELEASE FROM AIRWAY SMOOTH MUSCLE IN ACTIVELY SENSITIZED GUINEA PIG
- Ro Jai Youl (Department of Pharmacology, Yonsei University College of Medicine) ;
- Yoon Suk Jong (Department of Pharmacology, Yonsei University College of Medicine) ;
- Lee Jong Wha (Department of Biochemical Pharmacology, Korea Ginseng & Tobacco Research Institute) ;
- Kim Kyung Hwan (Department of Pharmacology, Yonsei University College of Medicine)
- Published : 1993.09.01
Abstract
It has been reported that ginseng is effective in the central nervous system, immune system, and the strong inflammatory responses. However, there has been no research report yet about the effect of ginseng on allergic hypersensitivity reactivity. To confirm the ginseng effects on the release of mediators(histamine. leukotrienes etc.) which cause the hypersensitivity reactivity and inflammatory response, we used actively sensitized guinea pig airway tissues by utilizing the superfusion technique. In this procedure. the contractile response and mediators released after antigen stimulation of sensitized tissues, and IgG and IgE antibody products were measured in sera of immunized animals. Then the results of the controll group were compared to those of ginseng pretreatment groups. In the total saponin(TS) and panaxatriol(PT) pretreatment, histamine release decreased by
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