Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)

The Korean Society of Ginseng (고려인삼학회)
권호 표지

LIPOPHILIC FRACTION FROM KOREAN RED GINSENG REGULATES THE PHOSPHORYLATION OF PLATELET PROTEIN(50KD) BY ELEVATING CYCLIC-GMP IN VIVO AND IN VITRO

  • Park H.J. (Department of Biochemical Pharmacology, Korea Ginseng & Tabacco Research Institute) ;
  • Rhee M.H. (Department of Biochemical Pharmacology, Korea Ginseng & Tabacco Research Institute) ;
  • Park K.M. (Department of Biochemical Pharmacology, Korea Ginseng & Tabacco Research Institute) ;
  • Nam K.Y. (Department of Biochemical Pharmacology, Korea Ginseng & Tabacco Research Institute) ;
  • Lee J.H. (Ewha Womans' Univ) ;
  • Park K.H. (Department of Biochemical Pharmacology, Korea Ginseng & Tabacco Research Institute)
  • Published : 1993.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

Lipophilic fraction(LF) from Panax ginseng C.A. Meyer inhibited the aggregation of human platelets induced by th rombin(0.1u/$m{\ell}$). LF and Molsidomine(vasodilator) induced the stimulation of cGMP - elevation and 50KD - Phosphorylation. and then the inhibition of 20KD - Phosphorylation in human platelets activated by thrombin. LF also inhibited the $Ca^{2-}-influx$ into platelets. When rat(SD : male) was fed with LF, the level of cGMP was increased in rat platelets stimulated by collagen and thrombin. On the other hand. verapamil, $Ca^{2-}-antagonist$ increased cAMP level ;n platelet stimulated by thrombin. but LF does not affected. However LF potently inhibited the thromboxane $A_2(TXA_2)$ production. The results suggest that the inhibitory effects of LF are mediated by regulation the phosphorylatior. of 50KD via cGMP-elevation and depend upon the decrease of $TXA_2$ level.

Keywords