Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.139-139
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- 2001
Potent inhibition of Lipopolysaccharide-Inducible Nitric Oxide Synthase Expression by Dibenzylbutyrolactone Lignans through Inhibition of I-kB Phosphorylation and of p65 Nuclear Translocation in Macrophages
- Cho, Min-Kyung (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Park, Jung-Won (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Jang, Young-Pyo (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
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Kim, Sang-Geon
(College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
- Published : 2001.05.01
Abstract
Arctigenin and demethyltraxillagenin, dibenzylbutyrolactone lignans, are phenylpropanoid plant metabolites with antioxidative and anti-inflammatory activities. The effects of arctigenin and demethyltraxillagenin on the nuclear factor-kB (NF-kB)-mediated inducible nitric oxide synthase (iNOS) gene expression were studied in Raw264.7 cells.(omitted)
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