Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)
- 2003.09b
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- Pages.357-368
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- 2003
Phase behaviors, lamellar structures, and physical properties of synthetic vitamin E ceramide (Tocomide) mixed with cholesterol and linoleic acid
- Lee, Young-Jin (Amore-Pacific Corporation R&D Center) ;
- Kim, Do-Hoon (Amore-Pacific Corporation R&D Cente) ;
- Park, Ho-Sik (Amore-Pacific Corporation R&D Cente) ;
- Kang, Hyung-Seok (Amore-Pacific Corporation R&D Cente) ;
- Kim, Joong-Soo (Amore-Pacific Corporation R&D Cente) ;
- Kim, Han-Kon (Amore-Pacific Corporation R&D Center)
- Published : 2003.09.01
Abstract
II-A isotherms and phase behaviors of 'tocomide', a newly synthesized 1,3-bis(N-(2-hydroxyethyl)-tocopherol succinylamino)-2-hydroxypropane, mixed with cholesterol and linoleic acid, was studied for its monolayer miscibility and a stable delivery formulation for antioxidant applications. The monolayer of tocomide and cholesterol was formed in a homogeneously mixed state at air-water interface. The ternary mixtures with linoleic acid showed various bulk structures, including a stable and transparent solution of thermodynamically stable lamellar phase. The lamellar structure was confirmed by the X-ray diffraction (XRD) patterns and polarized microscopy such that pure tocomide formed a liquid crystal at room temperature with a lamellar periodicity of 36.7