Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)

Society of Cosmetic Scientists of Korea (대한화장품학회)
권호 표지

EFFICACY EVALUATION OF THE WHITENING COSMETICS USING MELANOGENESIS INHIBITION ASSAY COSMETICS IN B-16 MELANOMA CELL

  • S. J. Yang (Drug Evaluation Department, Korea Food and Drug Administration) ;
  • S. J. Jang (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Park, S. S. (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • J. Y. Jang (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • K. H. Son (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Lee, J. P. (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • Lee, K. S. (Drug Evaluation Department, Korea Food and Drug Administratio) ;
  • M. Y. Heo (College of Pharmacy, Kangwon National Universit) ;
  • Kim, Y. O. (Drug Evaluation Department, Korea Food and Drug Administration)
  • Published : 2003.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

We investigated the inhibitory effect of whitening materials with growth factor or alone on melanomas derived from Human (B-16) and mouse (SK-MEL-31) using melanin content. Melanin content was determined by the absorbance value at 470nm per cells. we used the growth factors known as activators of Adenylate cyclase, Protein kinase C and tyrosine kinase pathway separately. In addition, we compared the action of UV-induced with non-biological growth factor with whitening materials in melanomas derived from Human and mouse. The results showed that the aspect of inhibitory effect of whitening materials on B16 and SK-MEL-31 was not different. And, the action of each growth factor involved in the differentiation and proliferation of melanoma on the inhibition of melanogenesis in B-16 and SK-MEL-31 using whitening agents showed no difference. Also, The action of UV -induced and non-biological growth factors didn't exhibit different pattern on the effect of whitening agent in B-16 and SK-MEL-31.

Keywords