Inhibitory Action of Phenylpropanoids on Phospholipase A2 and Phosphodiesterase in Athmatic Guinea Pig Lung

  • Kim, Youn-Joung (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Lee, Ji-Yun (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Lee, Jin-Hee (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Kim, Tae-Doo (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Sim, Sang-Soo (Department of Pathophysiology, College of Pharmacy, Chung Ang University) ;
  • Kim, Chang-Jong (Department of Pathophysiology, College of Pharmacy, Chung Ang University)
  • Published : 2003.04.01

Abstract

Effect of phenylpropanoids on Phospholipase A2 (PLA2) and phosphodiesterase (PDE) activities in the asthmatic lung tissue were studied in guinea pigs. Bronchial asthma were introduced by the challenge of aerosolized ovalbumin (OA) in the double-chambered plethysmograph at twenty one days after sensitization of OA in guinea pigs. Bronchoalveolar lavage fluids (BALF) were taken by brochalveolar lavage with HEPES buffer. (omitted)

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