Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.222.1-222.1
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- 2003
Role of hydrogen peroxide in Rac1 mediated activation of p70s6k signaling pathway
- Bae, Gyu-Un (College of Pharmacy, Sungkyunkwan University) ;
- Kwon, Hyoung-Keun (College of Pharmacy, Sungkyunkwan University) ;
- Kim, Gwan-Tae (College of Pharmacy, Sungkyunkwan University) ;
- Kim, Yong-Kee (College of Pharmacy, Sungkyunkwan University) ;
- Yoon, Jong-Woo (College of Pharmacy, Sungkyunkwan University) ;
- Cho, Eun-Jung (College of Pharmacy, Sungkyunkwan University) ;
- Lee, Hyang-Woo (College of Pharmacy, Sungkyunkwan University) ;
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Han, Jeung-Whan
(College of Pharmacy, Sungkyunkwan University)
- Published : 2003.04.01
Abstract
The signal transduction pathway leading to the activation of the p70s6k plays an important role in the progression of cells from G0/G1 to S phase of the cell cycle but remains incompletely characterized. We investigated the role of the Rho family G protein Rac1 in H2O2-mediated p70s6k activation. Transient expression of a dominant negative mutants of the small GTP-binding proteins Rac1 (Rac1N17) and Cdc42(Cdc42N17) showed reduced levels of slower migration on Western blots of one-dimensional SDS-PAGE in p70s6k and ERK1/2 by PDFG stimulation. (omitted)
Keywords