Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.245.2-245.2
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- 2003
Synthesis ot Brefeldin A Lactam Analogue
- Paek, Seung-Mann (College of Pharmacy, Seoul National University) ;
- Seo, Seung-Yong (College of Pharmacy, Seoul National University) ;
- Jung, Jae-Kyung (College of Pharmacy, Seoul National University) ;
- Han, Young-Taek (College of Pharmacy, Seoul National University) ;
- Seo, Young-Ger (College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
(+)-Brefeldin A (1) has been, since its isolation1 and structural elucidation2 many years ago, one of the most attractive targets for synthetic chemists due to its wide range of biological activities and well-functionalized macrolide structure. Its biological mode of action has been disclosed by a number of important discoveries. Especially the ability of brefeldin A to induce DNA fragmentation associated with apoptosis in cancer cells has stimulated a great deal of recent interest in its preclinical development as an anticancer agent. (omitted)
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