Binding of Nalidixic Acid with Plasma Protein -On the Species Difference in Binding-

Nalidixic Acid와 혈장단백(血漿蛋白)과 결합(結合)에 관(關)한 연구(硏究) -동물(動物)의 종속차(種屬差)에 대(對)하여-

Binding of nalidixic acid with plasma of male and female rats, dogs, and rabbits was studied in vitro using the method of equilibrium dialysis in 1/15 mole phosphate buffer (pH 7.4). Rat plasma had the most extensive binding capacity followed by dog and rabbit plasma, and the plasma of female had more extensive capability than male in rat and rabbit but it was reversed in dog.