The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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A Study on the Microbiological Assay of Bacampicillin Hydrochloride

염산바캄피실린의 역가 검정법에 관한 연구

  • Chung, Kyeong-Soo (Department of Microbial Chemistry, College of Pharmacy Seoul National University) ;
  • Kim, Young-Jun (Department of Microbial Chemistry, College of Pharmacy Seoul National University) ;
  • Lee, Song-Ae (Department of Microbial Chemistry, College of Pharmacy Seoul National University) ;
  • Kim, Byung-Kak (Department of Microbial Chemistry, College of Pharmacy Seoul National University)
  • 정경수 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김영준 (서울대학교 약학대학 미생물약품화학교실) ;
  • 이송애 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김병각 (서울대학교 약학대학 미생물약품화학교실)
  • Published : 1980.03.30
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Abstract

To establish a competent method of microbiological assay for bacampicillin, one of new semi-synthetic derivatives of ${\beta}-lactam$ antibiotics, a comparison was carried out between different conditions for hydrolysis of bacampicillin into ampicillin which was then subjected to cylinder plate method. The results showed that the use of carboxylic ester hydrolase in vitro as a pretreatment of it in either pH value 6 or 8 was feasible and that the cylinder plate method with Sarcina lutea was adequate for potency estimation.

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