생약학회지 (Korean Journal of Pharmacognosy)

  • 제13권3호
  • /
  • Pages.112-115
  • /
  • 1982
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

택사(澤瀉)로부터 분리(分離)한 Alisol 성분(成分)의 간(肝) 보호작용(保護作用)

Liver-protective Activities of Alisol Compounds against $CCl_4$ Intoxication

  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
  • Kim, Young-Soo (Natural Products Research Institute, Seoul National University) ;
  • Yun, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
  • Kim, Sun-Ok (Natural Products Research Institute, Seoul National University)
  • 발행 : 1982.09.30
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초록

Alisol A monoacetate, alisol B monoacetate, alisol C monoacetate and alisol B were isolated from Alismatis Rhizoma, which is a herbal drug used frequently in the oriental prescriptions. Potential liver-protective activities of the isolated alisol compounds were evaluated against $CCl_4-induced$ liver damage. The results obtained from liver microsomal enzyme assay, measurement of serum glutamic pyruvic transaminase (EC 2.6.1.2) and serum triglyceride content indicated that alisol A,B and C monoacetates showed significant liver-protective activities against $CCl_4$ poisoning. Alisol B monoacetate exhibited slightly higher activity than that of alisol B.

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