Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Experimental Studies on Antitumor Activity of Herb Drugs (II)-Sensitivity Testing of Tumor Cell to Drugs-

수종(數種)의 생약(生藥)에 대(對)한 항암효과(抗癌效果)의 실험적(實驗的) 연구(硏究)(II)-약물(藥物)에 대(對)한 암세포(癌細胞)의 감수성분석(感受性分析)-

  • Yim, Jai-Hoon (School of Oriental Medicine, Kyung Hee University) ;
  • Woo, Hong-Jung (School of Oriental Medicine, Kyung Hee University) ;
  • Kim, Byung-Woon (School of Oriental Medicine, Kyung Hee University) ;
  • Ha, Youn-Mun (School of Medicine, Kyung Hee University) ;
  • Lee, Seung-Hoon (School of Medicine, Kyung Hee University) ;
  • Nam, Sang-Yun (Immunology Research Labortory, Kyung Hee University Medical Center) ;
  • Choi, Yong-Mook (Immunology Research Labortory, Kyung Hee University Medical Center)
  • 임재훈 (경희대학교 한의과대학) ;
  • 우홍정 (경희대학교 한의과대학) ;
  • 김병운 (경희대학교 한의과대학) ;
  • 하윤문 (경희대학교 의과대학) ;
  • 이승훈 (경희대학교 의과대학) ;
  • 남상윤 (경희의료원 암센타 면역연구소) ;
  • 최용묵 (경희의료원 암센타 면역연구소)
  • Published : 1987.06.30
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Abstract

In vitro sensitivity testing was performed for 21 kinds putative anticancer drugs selected from references and information. Cellular damage of P815 mastocytoma cells following exposure to water extracts of drugs was evaluated by colony formation assay. Highly effective drugs with more than 50% inhibition of colony formation were seven (Houttuyniae Herba, Sanguisorbae Radix, Nepetae Herba, Manitis Squama, Lonicerae Flos, Amomi Semen, Polyporus), though not more effective than BCNU. According to the results of $^3H-thymidine$ incorporation assay for determination of selective cytotoxicity, 3 of these drugs (Houttuyniae Herba, Polyporus, Manitis Squama) were found to be low cytotoxic to normal mouse lymphoid cells. These findings suggest that the above 3 drugs may be used for effective anticancer drugs in vivo.

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