YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Captafol on the Serum Parameter and Drug Metabolizing Enzyme in Rats

Captafol이 혈액상(血液像) 및 약물대사효소(藥物代謝酵素)에 미치는 영향(影響)

  • Park, Kui-Lea (College of Pharmacy, Sung Kyun Kwan University) ;
  • Hong, Sa-Uk (College of Pharmacy, Sung Kyun Kwan University)
  • 박귀래 (성균관대학교 약학대학) ;
  • 홍사욱 (성균관대학교 약학대학)
  • Published : 1989.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Examination of the subacute toxicity of captafol showed that. 1) In the captafol administered group, the body weight was significantly decreased but the amounts of AST, ALT, LDH, BUN, TG in serum were remarkably elevated in comparision to those of the control group. 2) In captafol treated animals, the amount of cytochrome P-450 and the activity of NADPH-cytochrome c reductase in liver and in kidney were decreased, but TAB value in serum and in liver and total ATPase activity in liver and in kideny were found to be remakably elevated. 3) When captafol administered with ethanol to the group, the group showed elevated serum levels of AST, ALT and BUN but the amount of cytochrome P-450 and the activity of NADPH-cytochrome c reductase in liver and in kidney were decreased as the group which was treated with captafol only.

Keywords