Designing of Antiepileptic Ligands by Esterification and Acetylation of Dipeptides

Glycylglycine, alanylalanine and alanylglycine were synthesized, their free carboxylic and amino groups were converted to methyl esters of N-acetylglycyglycine, N-acetylalanylglycine and N-acetylalanylalanine. The synthesized compounds were evaluated for antiepileptic activity, plasmaprotein binding, $TD_{50}$ and potentiating effect of phenobarbitone sodium.