Acknowledgement
Supported by : 한국과학재단
Korean Journal of Veterinary Research (대한수의학회지)
- Volume 32 Issue 1
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- Pages.25-34
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- 1992
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Immunotoxic effects of vomitoxin
Vomitoxin의 면역 독성효과
- Kim, Jong-shu (College of Veterinary Medicine, Gyeongsang National University) ;
- Kim, Yong-hwan (College of Veterinary Medicine, Gyeongsang National University)
- Received : 1991.10.03
- Published : 1992.01.30
Abstract
The present study were carried out to investigate the effects of Vomitoxin(Deoxynivalenol, DON) induced dysregulation of IgA synthesis. The data presented here demonstrate that exposure to dietary DON increases serum IgA and concurrently decreases IgG and IgM. Peyer's path(PP) and splenocytes from mice fed dietary DON produced increased IgA in mitogen stimulated and macrophage(MØ) perform essential role for Ig synthesis and was affected by the presence of DON. The synthesis and secretion of IgM and IgG under the presence of DON do not require T cell helper activity, whereas those of IgA do require such activity. These results suggest that dietary DON alters the regulation of IgA production and may act as an immunostimulator.
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