Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Biological Properties and Structural Analysis of Novel Antifungal Antibiotics AF-011A

신규 항진균물질 AF-011A의 생물학적 활성 및 구조분석

  • 서정우 (제일제당(주)종합연구소) ;
  • 임융호 (제일제당(주)종합연구소) ;
  • 현봉철 (제일제당(주)종합연구소) ;
  • 김창완 (제일제당(주)종합연구소) ;
  • 연창석 (제일제당(주)종합연구소) ;
  • 이덕근 (제일제당(주)종합연구소) ;
  • 김광표 (제일제당(주)종합연구소) ;
  • 정재경 (제일제당(주)종합연구소) ;
  • 이철훈 (제일제당(주)종합연구소)
  • Published : 1993.12.01
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Abstract

AF-001A is a novel antifungal cyclic glyco-peptise isolated from Pseudomonas cepacia AF6008. AF-001A is a mixture of AF-011A1 and AF-001A2. Each compound contains glycine(1), serine(2), asparagine(1), 2,4-diaminobutyric acid(1), beta-hydroxytyrosine(1), xylose(1) and a methylene chain amino acid(1). Additionally, A1 contains one beta-hydroxyasparagine that is replaced with as asparagine in A2. AF-011A showed high in vitro antifungal activity against various animal and plant pathogenic fungi and caused no irritation on the skin of rabbits.

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References

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