약학회지 (YAKHAK HOEJI)
- 제38권3호
- /
- Pages.265-273
- /
- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
새로운 퀴놀론계 항균제 DWQ-013의 항균작용
In vitro and in vivo Antibacterial Activities of the New Quinolone, DWQ-013
- 유영효 ((주) 대웅제약 중앙연구소) ;
- 박남준 ((주) 대웅제약 중앙연구소) ;
- 김병오 ((주) 대웅제약 중앙연구소) ;
- 최문정 ((주) 대웅제약 중앙연구소) ;
- 심점순 ((주) 대웅제약 중앙연구소) ;
- 강태충 ((주) 대웅제약 중앙연구소) ;
- 이재욱 ((주) 대웅제약 중앙연구소) ;
- 김대영 (순천향대학교 화학과)
- Yu, Young-Hyo (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Park, Nam-Jun (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Kim, Byung-O (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Choi, Moon-Jung (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Shim, Jeom-Soon (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Kang, Tae-Chung (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Lee, Jae-Wook (R&D Center, Dae Woong Pharmaceutical Co., Ltd.) ;
- Kim, Dae-Young (Department of Chemistry, Soonchunhyang University)
- 발행 : 1994.06.30
초록
ln vitro and in vivo antibacterial activities of DWQ-013(1-cyclopropyl-6,8-difluoro-7-(3-methylthiomethylpyrrolidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid), a new fluoroquinolone antibacterial agent, were compared with those of ciprofloxacin, sparfloxacin and ofloxacin against aerobic and anaerobic standard strains and clinical isolates. DWQ-013 had a broad spectrum and potent antibacterial activity against Gram-positive and Gram-negative bacteria. The antibacterial activity of DWQ-013 against Staphylococcus aureus was equal to that of sparfloxacin(SPFX) and superior to those of ciprofloxacin(CPFX). The antibacterial activity against Gram-negative bacteria was slightly lower than those of ciprofloxacin and sparfloxacin. MIC of DWQ-013 against Pseudomonas aeruginosa
키워드