Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지

Evaluation of Ulcerogenic Activity of Ketoprofen Gel

케토프로펜 겔의 궤양형성작용 평가

  • 단현광 (일동제약(주) 중앙연구소) ;
  • 지상철 (성균관대학교 약학대학) ;
  • 전흥원 (미국 조지아대학교 약학대학)
  • Published : 1994.06.20
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Abstract

The ulcerogenic activity of a 3% ketoprofen gel (ID-GEL) after its transdermal application in rats was determined with the Litchfield and Wilcoxon method in reference to the oral administration of ketoprofen in a suspension. The $UD_{50}$ (dose producing ulcers in 50%, of the rats tested) of ID-GEL after its transdermal application was approximately 4 times greater than that after the oral administration of the drug, indicating that the ulcerogenic activity of ketoprofen was much lowered with its transdermal application.

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